Effects of diabetes mellitus on the contractile activity of carbachol and galanin in isolated gastric fundus strips of rats

Pharmacology

Volumn 57, Issue 2, 1998, Pages 65-78

  Korolkiewicz, Roman ^a   Rekowski, Piotr ^b   Szyk, Agnieszka ^b   Kato, Shinichi ^a   Yasuhiro, Tetsuya ^a   Kubomi, Masafumi ^a   Tashima, Kimihito ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF GDA SK   (Poland)

Author keywords

Carbachol; Diabetes; Galanin; Gastric smooth muscle, rat; Nitric oxide

Indexed keywords

CALCIUM ION; CARBACHOL; GALANIN; INSULIN; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FEMALE; INSULIN TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; STOMACH FUNDUS; STOMACH MOTILITY; STOMACH MUCOSA; STOMACH MUSCLE; STOMACH PARESIS;

ANIMALS; CARBACHOL; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; GALANIN; GASTRIC FUNDUS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

EID: 0031927922     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028227     Document Type: Article

References (52)

1. Katz LA, Spiro HM: Gastrointestinal manifestations of diabetes. N Engl J Med 1966;275:1350-1361.
2. O'Reilly D, Long RG: Diabetes and the gastrointestinal tract. Dig Dis 1987;5:57-64.
3. Öztürk Y, Altan VM, Yildizoglu-Ari N: Effects of experimental diabetes and insulin on smooth muscle functions. Pharmacol Rev 1996;48:69-112.
4. Granneman JG, Stricker EM: Food intake and gastric emptying in rats with streptozocin-induced diabetes. Am J Physiol 1984;247:R1054-R1061.
5. Scott LD, Ellis TM: Small intestinal transit and myoelectric activity in diabetic rats; in Christensen J (ed): Gastrointestinal Motility. New York, Raven Press, 1980, pp 359-399.
6. Mathison R, Davison JS: Modified smooth muscle responses of jejunum in streptozocin-diabetic rats. J Pharmacol Exp Ther 1988;244: 1045-1050.
7. Altan VM, Yildizoglu-Ari N, Öztürk Y: Decreased gastrointestinal responses to certain agonists in streptozocin-and alloxan-diabetic rats in vitro. Pharmacology 1987;34:143-148.
8. Bell RH Jr, Hye RJ: Animal models of diabetes mellitus: Physiology and pathology. J Surg Res 1983;35:433-460.
9. Tatemoto K, Rökaeus A, Jörnvall H, McDonald TJ, Mutt V: Galanin: A novel biologically active peptide from porcine intestine. FEBS Lett 1983;164:124-128.
10. Ekblad E, Häkanson R, Sundler F, Wahlestedt C: Galanin: Neuromodulatory and direct contractile effects on smooth muscle preparations. Br J Pharmacol 1985;86:241-246.
11. Herling H: Galanin: A candidate neurotransmitter in the porcine gastrointestinal tract. Dan Med Bull 1993;40:511-518.
12. Muramatsu I, Yanaihara N: Contribution of galan in to non-cholinergic, non-adrenergic transmission in rat ileum. Br J Pharmacol 1988;94: 1241-1249.
13. Fox JE, McDonald TJ, Kostolanska F, Tatemoto K: Galanin: An inhibitory neural peptide of the canine small intestine. Life Sci 1986;39: 103-110.
14. Lincoln J, Bokor JT, Crowe R, Griffith SG, Haven AJ, Burnstock G: Myenteric plexus in streptozocin treated rats. Neurochemical and histochemical evidence for diabetic neuropathy in the gut. Gastroenterology 1984;86:654-661.
15. Buchan AMJ: Effect of diabetes in the BB Wistar rat on the peptidergic component of enteric innervation. Digestion 1990;46(suppl 2): 142-147.
16. G-nitro-L-arginine methyl ester in streptozocin-induced diabetes mellitus. Br J Pharmacol 1992;106:1035-1040.
17. Martinez-Cuesta MA, Massuda H, Whittle BJR, Moncada S: Impairment of nitrergic-mediated relaxation of rat isolated duodenum by experimental diabetes. Br J Pharmacol 1995;114:919-924.
18. Takeuchi K, Ueshima K, Ohuchi T, Okabe S: Induction of gastric lesions and hypoglycemic response by food deprivation in streptozocin-diabetic rats. Dig Dis Sci 1994;39:626-634.
19. Vane JR: A sensitive method for the assay of 5-hydroxytryptamine. Br J Pharmacol 1957;12:344-349.
20. Sliwinski W, Korolkiewicz R, Rekowski P, Halama A, Korolkiewicz KZ: Actions of galanin and some of its analogues on rat isolated gastric fundus. Fundam Clin Pharmacol 1996;10:442-449.
21. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR: Analysis of nitrate, nitrite and 15N-nitrate in biological fluids. Anal Biochem 1982;126:131-138.
22. Boughton-Smith N, Evans SM, Laszlo F, Whittle BJR, Moncada S: The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in rat. Br J Pharmacol 1993;110:1189-1195.
23. Tallarida RJ, Murray RB: Manual of Pharmacologic Calculations with Computer Programs, ed 2. New York, Springer, 1986.
24. Barlow RB: Biodata Handling with Microcomputers. Programs Written in BASIC for Handling Biological, Biochemical, Pharmacological and Physiochemical Results - With a Commentary on the Calculations Involved. Amsterdam, Elsevier, 1983.
25. Pappano AJ, Watanabe AM: Cholinoceptor-activating and cholinesterase-inhibiting drugs; in Katzung BG (ed): Basic and Clinical Pharmacology. Norwalk, Appleton & Lange, 1995, pp 88-101.
26. Lucas PD, Sardar AM: Effects of diabetes on cholinergic transmission in two rat gut preparations. Gastroenterology 1984;100:123-128.
27. Takahashi T, Kojima Y, Tsunoda Y, Beyer LA, Kamijo M, Sima AA, Owyang C: Impaired intracellular signal transduction in gastric smooth muscle of diabetic BB/W rats. Am J Physiol 1996;270:G411-G417.
28. Soulie ML, Cros G, Serrano JJ, Bali JP: Impairment of contractile response to carbachol and muscarinic receptor coupling in gastric antral smooth muscle cells isolated from diabetic streptozocin-treated rats and db/db mice. Mol Cell Biochem 1992;109:185-188.
29. Kamata K, Sakamoto A, Kasuya Y: Changes in the sensitivity of rat stomach fundus to various drugs in streptozocin-induced diabetic rats. Jpn J Pharmacol 1988;47:99-102.
30. Aihara K, Sakai Y: Hyperreactivity of contractile response in the gastric fundus smooth muscle from rats with diabetes induced by streptozotocin. Arch Int Pharmacodyn Ther 1989;302:220-231.
31. Hoyle CHV, Reilly WM, Lincoln J, Burnstock G: Adrenergic, but not cholinergic or purinergic responses are potentiated in the cecum of diabetic rats. Gastroenterology 1988; 94:1357-1367.
32. Belai A, Lefebvre RA, Burnstock G: Motor activity and neurotransmitter release in the gastric fundus of streptozotocin-diabetic rats. Eur J Pharmacol 1991;194:225-234.
33. Tallarida RJ, Raffa RB, McGonigle P: Radioligand binding. Direct binding. Hill plot: in Tallarida RJ, Raffa RB, Mc Gonigle P (eds): Principles in General Pharmacology. New York, Springer, 1988, pp 211-214.
34. Laurence D, Carpenter J: A Dictionary of Pharmacology and Clinical Drug Evaluation. London, UCL Press, 1994, pp 102-103.
35. Barada K, Okolo C, Field M, Cortas N: Na, K-ATPase in diabetic rat small intestine: Changes at protein and mRNA levels and role of glucagon. J Clin Invest 1994;93:2725-2731.
36. Takahashi T, Nakamura K, Itoh H, Sima AAF, Owyang C: Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneous diabetic rats. Gastroenterology 1997;113:1535-1544.
37. Contreras R, Fuentes O, Mann GE, Sobrevia L: Diabetes and insulin-induced stimulation of L-arginine transport and nitric oxide synthesis in rabbit isolated gastric glands. J Physiol (Lond) 1997;498:787-796.
38. Kröncke K-D, Bachofen-Kolb V, Berschick B, Burkart V, Kolb H: Activated macrophages kill pancreatic syngenic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 1991;175:752-758.
39. Grider JR, Murthy KS, Jin J-G, Makhlouf GM: Stimulation of nitric oxide from muscle cells by VIP: Prejunctional enhancement of VIP release. Am J Physiol 1992;262: G774-G778.
40. Brown JF, Tepperman BL, Hanson PJ, Whittle BJR, Moncada S: Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem Biophys Res Commun 1990;184:680-685.
41. Lefebvre RA, Smits GJ, Timmermans JP: Study of NO and VIP as non-adrenergic non-cholinergic neurotransmitters in the pig gastric fundus. Br J Pharmacol 1995;116: 2017-2026.
42. Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T, Nyengaard JR, van den Enden M, Kilo C, Tilton RG: Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 1993;42:801-813.
43. Wrzos HF, Cruz A, Polavarapu R, Shearer D, Ouyang A: Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats. Dig Dis Sci 1997;42: 2106-2110.
44. Nowak TV, Harrington B, Kalbfleisch JA, Anatruda JM: Evidence for abnormal cholinergic transmission in diabetic rat small intestine. Gastroenterology 1989;91:124-132.
45. Schmidt RE, Plurad SB, Modert CW: Experimental diabetic autonomic neuropathy characterization in streptozotocin-diabetic Sprague-Dawley rats. Lab Invest 1983;49: 538-552.
46. Monckton G, Pehowich E: Autonomic neuropathy in the streptozocin diabetic rats. Can J Neurol Sci 1980;7:135-142.
47. Kennedy L, Baynes JW: Non-enzymatic glycosylation and chronic complications of diabetes: An overview. Diabetologia 1984;26:93-98.
48. Fagan JM, Satarug S, Cook P, Tischler ME: Rat muscle protein turnover and redox state in progressive diabetes. Life Sci 1987;40:783-790.
49. Morgan HE, Rannels DE, Wolpert EB, Giger KE, Robertson JW, Jefferson LS: Effect of insulin on protein turnover in rat heart and skeletal muscle; in Fritz IB (ed): Insulin Action. New York, Academic Press, 1972, pp 437-459.
50. Rana RS, Hokin LE: Role of phosphoinositides in transmembrane signaling. Physiol Rev 1990;70:115-164.
51. Chilvers ER, Batty IH, Barnes PJ, Nahorski SR: Formation of inositol phosphates in airway smooth muscle after muscarinic receptor stimulation. J Pharmacol Exp Ther 1990; 252:786-791.
52. Clarke BF, Ewing DJ, Campbell IW: Diabetic autonomie neuropathy. Diabetologia 1979;17:195-212.