Is 1, 25-dihydroxyvitamin D3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro?

Chinese Medical Journal

Volumn 119, Issue 15, 2006, Pages 1278-1286

  Zhou, Yong Sheng ^a   Liu, Yun Song ^a   Tan, Jian Guo ^a  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

Author keywords

1, 25 dihydroxyvitamin D3; Dexamethasone; Human adipose tissue derived stromal cell; Osteoblast

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; CALCITRIOL; CELL MARKER; COLLAGEN TYPE 1; DEXAMETHASONE; LIM PROTEIN; MESSENGER RNA; OSTEOCALCIN; OSTEOGENIC PROTEIN 1; OSTERIX; SIALOPROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ADULT; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINEAGE; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MINERALIZATION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; STROMA CELL; UPREGULATION;

EID: 33747318207     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200608010-00008     Document Type: Article

References (27)

1. Zuk PA, Zhu M, Ashjian P, de Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13: 4279-4295.
2. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7: 211-228.
3. Hicok KC, Du Laney TV, Zhou YS, Halvorsen YD, Hitt DC, Cooper LF, et al. Human adipose-derived adult stem cells produce osteoid in vivo. Tissue Eng 2004; 10: 371-380.
4. Jiang X, Chen J, Sebastien G, Chen C, Zhang X, Zhang Z. The ectopic study of tissue-engineered bone with hBMP-4 gene modified bone marrow stromal cells in rabbits. Chin Med J 2005;118:281-288.
5. Cooper MS, Hewison M, Stewart PM. Glucocorticoid activity, inactivity and the osteoblast. J Endocrinol 1999; 163: 159-164.
6. 3 enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts. Steroids 2004;69: 219-226.
7. Halvorsen YD, Franklin D, Bone AL, Hitt DC, Auchter C, Boskey AL, et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng 2001;7: 729-741.
8. 3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow. Endocrinology 1997;138:4629-4635.
9. Montero-Odasso M, Duque G. Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone. Mol Aspects Med 2005;26: 203-219.
10. Walsh S, Jefferiss C, Stewart K, Jordan GR, Screen J, Beresford JN. Expression of the developmental markers STRO-1 and alkaline phosphatase in cultures of human marrow stromal cells: regulation by fibroblast growth factor (FGF)-2 and relationship to the expression of FGF receptors 1-4. Bone 2000;27:185-195.
11. Weiss MJ, Ray K, Henthorn PS, Lamb B, Kadesch T, Harris H. Structure of the human liver/bone/kidney alkaline phosphatase gene. J Biol Chem 1988;263: 12002-12010.
12. Aubin JE, Triffitt JT. Mesenchymal stem cells and osteoblast differentiation. In: Bilezikian JP, Raisz LG, Rodan GA, eds. The Principles of Bone Biology, 2nd edition. San Diego: Academic press;2002:59-82.
13. 3 on osteogenic differentiation of human marrow stromal cells in vitro. Arch Oral Biol 1994;39:941-947.
14. Stein GS, Lian JB, Montecino M, van Wijnen AJ, Stein JL, Javed A, et al. Involvement of nuclear architecture in regulating gene expression in bone cells. In: Bilezikian JP, Raisz LG, Rodan GA, eds. The Principles of Bone Biology, 2nd edition. San Diego: Academic press;2002: 169-188.
15. Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, et al. Progressive development of the rat osteoblast phenotype in-vitro: reciprocal relationships in the expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 1990;143:420-430.
16. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, et al. Targeted disruption of Runx2/Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997;89: 755-764.
17. Schinke T, Karsenty G. Transcriptional control of osteoblast differentiation and function. In: Bilezikian JP, Raisz LG, Rodan GA, eds. The Principles of Bone Biology, 2nd edition. San Diego: Academic press; 2002: 83-89.
18. Igarashi M, Kamiya N, Hasegawa M, Kasuya T, Takahashi T, Takagi M. Inductive effects of dexamethasone on the gene expression of Runx2/ Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts. J Mol Histol 2004;35:3-10.
19. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 2002;108: 17-29.
20. Sakou T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone 1998; 22: 591-603.
21. Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Runx2/Cbfa1. Endocr Rev 2000;21:393-411.
22. Urist MR. Bone morphogenetic protein: the molecularization of skeletal system development. J Bone Miner Res 1997; 123:343-346.
23. Boden SD, Hair G, Titus L, Racine M, McCuaig K, Wozney JM, et al. Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6. Endocrinology 1997;138: 2820-2828.
24. Liu Y, Titus L, Barghouthi M, Viggeswarapu M, Hair G, Boden SD. Glucocorticoid regulation of human BMP-6 transcription. Bone 2004;35:673-681.
25. Boden SD, Titus L, Hair G, Liu Y, Viggeswarapu M, Nanes MS, et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine 1998;23:2486-2492.
26. Boden SD, Liu Y, Hair GA, Helms JA, Hu D, Racine M, et al. LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation. Endocrinology 1998;139: 5125-5134.
27. Minamide A, Boden SD, Viggeswarapu M, Hair GA, Oliver C, Titus L. Mechanism of bone formation with gene transfer of the cDNA encoding for the intracellular protein LMP-1. J Bone Joint Surg Am 2003;85-A: 1030-1039.