The ectopic study of tissue-engineered bone with hBMP-4 gene modified bone marrow stromal cells in rabbits

Chinese Medical Journal

Volumn 118, Issue 4, 2005, Pages 281-288

  Jiang, Xin Quan ^a   Chen, Jian Guo ^b   Gittens, Sébastien ^c   Chen, Chuan Jun ^a   Zhang, Xiu Li ^a   Zhang, Zhi Yuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Bone marrow stromal cells; Bone morphogenetic protein; Gene therapy; Tissue engineering

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 4; ENHANCED GREEN FLUORESCENT PROTEIN; HYDROXYAPATITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; GENE CONSTRUCT; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STROMA CELL; TISSUE ENGINEERING;

ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; OSTEOGENESIS; PLASMIDS; RABBITS; STROMAL CELLS; TISSUE ENGINEERING;

EID: 14644422246     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Bauer TW, Muschler GF. Bone graft materials. An overview of the basic science. Clin Orthop 2000;371: 10-27.
2. Vacanti CA, Bonassar LJ. An overview of tissue engineered bone. Clin Orthop 1999;367(Suppl):s375-s381.
3. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic issues. Science 1997:276:71-74.
4. Krebsbach PH, Mankani MH, Satomura K, et al. Repair of craniotomy defects using bone marrow stromal cells. Transplantation 1998;66:1272-1278.
5. Petite H, Viateau V, Bensaid W. et al. Tissue-engineered bone regeneration. Nat biotechnol 2000; 18:959-963.
6. Alden TD, Varady P, Kallmes DF, et al. Bone morphogenetic protein gene therapy. Spine 2002;27 (16 Suppl 1 ):s87-s93.
7. Chang SC, Chuang HL, Chen YR, et al. Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration. Gene Ther 2003;10:2013-2019.
8. Hidaka C, Goshi K, Rawlins B, et al. Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine 2003;28:2049-2057.
9. Li JZ, Hankins GR, Kao C, et al. Osteogenesis in rats induced by a novel recombinant helper-dependent bone morphogenetic protein-9 (BMP-9) adenovirus. J Gene Med 2003;5:748-756.
10. Lieberman JR, Daluiski A, Stevenson S, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg Am 1999;81:905-917.
11. Moutsatsos IK, Turgeman G, Zhou S, et al. Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol Ther 2001;3:449-461.
12. Tsuda H, Wada T, Ito Y, et al. Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector. Mol Ther 2003;7: 354-365.
13. Li JZ, Li H, Sasaki T, et al. Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat. Gene Ther 2003; 20:1735-1743.
14. Reddi AH. Bone morphogenetic proteins: from basic science to clinical applications. J Bone Joint Surg Am 2001;83-A Suppl 1 (Pt 1):s1-s6.
15. Kang R, Ghivizzani SC, Muzzonigro TS, et al. Orthopaedic applications of gene therapy. From concept to clinic. Clin Orthop 2000;375:324-337.
16. Yaoita H, Orimo H, Shirai Y, et al. Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture. J Bone Miner Metab 2000;18:63-70.
17. Peng H, Wright V, Usas A, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 2002;110:751-759.
18. Gysin R, Wergedal JE, Sheng MH, et al. Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats. Gene Ther 2002;9: 991-999.
19. Zhang XS, Linkhart TA, Chen ST, et al. Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice. J Gene Med 2004;6:4-15.
20. Scaduto AA, Lieberman JR. Gene therapy for osteoinduction. Orthop Clin North Am 1999; 30: 625-633.
21. Ma G, Han X, Wang Y, et al. Processing of natural non-organic bone and experimental study of its effect on bone formation. Chin J Repar Reconstr Surg (Chin) 1996;10:35-38.
22. Park J, Ries J, Gelse K, et al. Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther 2003;10:1089-1098.