The p22phox C242T gene polymorphism is associated with a reduced risk of angiographically verified coronary artery disease in a high-risk Finnish Caucasian population. The Finnish Cardiovascular Study

American Heart Journal

Volumn 152, Issue 3, 2006, Pages 538-542

  Fan, Meng ^a   Kähönen, Mika ^a   Rontu, Riikka ^a   Lehtinen, Rami ^a,b   Viik, Jari ^c   Niemi, Mari ^a   Nieminen, Tuomo ^d   Niemelä, Kari ^a   Pörsti, Ilkka ^d   Kööbi, Tiit ^a   Turjanmaa, Väinö ^a   Lehtimäki, Terho ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF APPLIED SCIENCES   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

P22 PHOX PROTEIN; PROTEIN; PYRIMIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TAQ POLYMERASE; UNCLASSIFIED DRUG;

ADULT; ALLELE; AMINO ACID SUBSTITUTION; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CAUCASIAN; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; DNA POLYMORPHISM; ENZYME SYNTHESIS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SAMPLE SIZE;

ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; CORONARY ARTERIOSCLEROSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FINLAND; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NADPH OXIDASE; POLYMORPHISM, GENETIC; RISK FACTORS; SUPEROXIDES;

EID: 33747291923     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2006.02.018     Document Type: Article

References (26)

1. Griendling K.K., and FitzGerald G.A. Oxidative stress and cardiovascular injury: part II: animal and human studies. Circulation 108 (2003) 2034-2040
2. Taniyama Y., and Griendling K.K. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 42 (2003) 1075-1081
3. Lassegue B., and Clempus R.E. Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol 285 (2003) R277-R297
4. Griendling K.K., Sorescu D., and Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86 (2000) 494-501
5. Ushio-Fukai M., Zafari A.M., Fukui T., et al. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271 (1996) 23317-23321
6. Azumi H., Inoue N., Takeshita S., et al. Expression of NADH/NADPH oxidase p22phox in human coronary arteries. Circulation 100 (1999) 1494-1498
7. Wyche K.E., Wang S.S., Griendling K.K., et al. C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension 43 (2004) 1246-1251
8. Guzik T.J., West N.E., Black E., et al. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation 102 (2000) 1744-1747
9. Inoue N., Kawashima S., Kanazawa K., et al. Polymorphism of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation 97 (1998) 135-137
10. Li A., Prasad A., Mincemoyer R., et al. Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function. Am J Med Genet 86 (1999) 57-61
11. Cai H., Duarte N., Wilcken D.E., et al. NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population. Eur J Clin Invest 29 (1999) 744-748
12. Gardemann A., Mages P., Katz N., et al. The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals. Atherosclerosis 145 (1999) 315-323
13. Cahilly C., Ballantyne C.M., Lim D.S., et al. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis. Circ Res 86 (2000) 391-395
14. Sonta T., Inoguchi T., Tsubouchi H., et al. Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity. Free Radic Biol Med 37 (2004) 115-123
15. Jaimes E.A., DeMaster E.G., Tian R.X., et al. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation. Arterioscler Thromb Vasc Biol 24 (2004) 1031-1036
16. Guzik T.J., West N.E., Black E., et al. Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors. Circ Res 86 (2000) E85-E90
17. Rajagopalan S., Kurz S., Munzel T., et al. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 97 (1996) 1916-1923
18. Guzik T.J., Mussa S., Gastaldi D., et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105 (2002) 1656-1662
19. 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens 17 (1999) 151-183
20. Viikari J., Ronnemaa T., Seppanen A., et al. Serum lipids and lipoproteins in children, adolescents and young adults in 1980-1986. Ann Med 23 (1991) 53-59
21. Raitakari O.T., Juonala M., Kahonen M., et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 290 (2003) 2277-2283
22. Pulkkinen A., Viitanen L., Kareinen A., et al. Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease. J Mol Med 78 (2000) 372-379
23. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285 (2001) 2486-2497
24. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26 Suppl 1 (2003) S5-S20
25. Mata-Balaguer T., de la Herran R., Ruiz-Rejon C., et al. Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population. Int J Cardiol 95 (2004) 145-151
26. Griendling K.K., Minieri C.A., Ollerenshaw J.D., et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74 (1994) 1141-1148