Interferon-γ increases IL-12 mRNA expression and attentuates allergic late-onset airway responses in the Brown Norway rat

European Respiratory Journal

Volumn 16, Issue 1, 2000, Pages 22-29

  Isogai, S ^b   Hamid, Q ^a   Minshall, E ^a   Miyake, S ^b   Yoshizawa, Y ^b   Taha, R ^a   Toda, M ^a   Martin, J G ^a   Watanabe, A ^b  

^a MCGILL UNIVERSITY   (Canada)

^b Meakins Christie Laboratories ^*

Author keywords

Airways; Allergic inflammation; Interferon gamma; Late airway response

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; OVALBUMIN;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL; GENE EXPRESSION; HELPER CELL; LUNG LAVAGE; LUNG RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY TRACT ALLERGY;

AIRWAY RESISTANCE; ANIMALS; ANTIGENS; BRONCHOALVEOLAR LAVAGE FLUID; IN SITU HYBRIDIZATION; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; INTERLEUKIN-5; MALE; OVALBUMIN; RATS; RATS, INBRED BN; RESPIRATORY HYPERSENSITIVITY; RNA, MESSENGER;

EID: 0033941750     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3003.2000.16a05.x     Document Type: Article

References (40)

1. Robinson DS, Hamid Q, Ying S, et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Eng J Med 1992; 326: 298-304.
2. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142: 1407-1413.
3. Aalbers R, Kauffman HF, Vrugt B, Koeter GH, de Monchy JG. Allergen-induced recruitment of inflammatory cells in lavage 3 and 24 h after challenge in allergic asthmatic lungs. Chest 1993; 103: 1178-1184.
4. Zangrilli JG, Shaver JR, Cirelli RA, et al. sVCAM-1 levels after segmental antigen challenge correlate with eosinophil influx, IL-4 and IL-5 production, and the late phase response. Am J Respir Crit Care Med 1995; 151: 1346-1353.
5. Gratziou C, Carroll M, Montefort S, Teran L, Howarth PH, Holgate ST. Inflammatory and T-cell profile of asthmatic airways 6 hours after local allergen provocation. Am J Respir, Crit Care Med 1996; 153: 515-520.
6. Maggi E, Parronchi P, Manetti R, et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992; 148: 2142-2147.
7. Del Prete G, Maggi E, Parronchi P, et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988; 140: 4193-4198.
8. Schleimer RP, Sterbinsky SA, Kaiser J, et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol 1992; 148: 1086-1092.
9. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-173.
10. Manetti R, Parronchi P, Giudizi MG, et al. Natural killer cell stimulatory factor (interleukin 12; IL-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 1993; 177: 1199-1204.
11. Maggi E, Parronchi P, Manetti R, et al. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992; 148: 2142-2147.
12. Li XM, Chopra RK, Chou TY, Schofield BH, Wills-Karp M, Huang SK. Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. J Immunol 1996; 157: 3216-3219.
13. Gavett SH, O'Hearn DJ, Li X, Huang S-K, Finkelman FD, Wills-Karp M. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness, inflammation and Th2-type cytokine expression in mice. J Exp Med 1995; 182: 1527-1536.
14. Iwamoto I, Nakajima H, Endo H, Yoshida S. Interferon-γ regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. J Exp Med 1993; 177: 573-576.
15. Eldelman DH, Bellofiore S, Martin JG. Late airway responses to antigen challenge in sensitized inbred rats. Am Rev Respir Dis 1988; 137: 1033-1037.
16. Bellofiore S, Martin JG. Antigen challenge of sensitized rats increases airway responsiveness to methacholine. J Appl Physiol 1988; 65: 1642-1646.
17. Schneider T, van Velzen D, Moqbel R, Issekutz AC. Kinetics and quantitation of eosinophil and neutrophil recruitment to allergic lung inflammation in a Brown Norway rat model. Am J Respir Cell Mol Biol 1997; 17: 702-712.
18. Watanabe A, Mishima H, Kotsimbos TC, et al. Adoptively transferred late allergic airway responses are associated with Th2-type cytokines in the rat. Am J Respir Cell Mol Biol 1997; 16: 69-74.
19. Haczku A, Macary P, Haddad EB, et al. Expression of Th2 cytokines interleukin-4 and -5 and of Th1 cytokine interferon-gamma in ovalbumin-exposed sensitized Brown Norway rats. Immunology 1996; 88: 247-251.
20. Frew AJ, Kay AB. The relationship between infiltrating CD4+ lymphocytes, activated eosinophils, and the magnitude of the allergen-induced late phase cutaneous reaction in man. Immunol 1988; 141: 4158-4164.
21. Eldelman DH, Minshall E, Dandurand RJ, et al. Evidence for major basic protein immunoreactivity and interleukin 5 gene activation during the late phase response in explanted airways. Am J Respir Cell Mol Biol 1996; 15: 582-589.
22. Hamid Q, Azzawl M, Ying S, et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991; 87: 1541-1546.
23. Naseer T, Minshall EM, Leung DY, et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. Am J Respir Crit Care Med 1997; 155: 845-851.
24. Lack G, Bradley KL, Hamelmann E, et al. Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice. J Immunol 1996; 1157: 1432-1439.
25. Hofstra CL, Van Ark I, Hofman G, Nijkamp FP, Jardieu PM, Van Oosterhout AJ. Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 1998; 19: 826-835.
26. Coyle AJ, Tsuyuki S, Bertrand C, et al. Mice lacking the IFN-γ receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J Immunol 1996; 156: 2680-2685.
27. Boguniewicz M, Martin RJ, Martin D, et al. The effects of nebulized recombinant interferon-γ in asthmatic airways. J Allergy Clin Immunol 1995; 95: 133-135.
28. Scholz D, Brandt-Hofflin K, Hahn HL. Effect of recombinant gamma interferon on allergic skin reaction and bronchoconstriction. Immunologie 1990; 44 (Suppl. 1): 431-432.
29. Garcia-Zepeda EA, Combadiere C, Rothenberg ME, et al. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3). J Immunol 1996; 157: 5613-5626.
30. Czech W, Krutmann J, Budnik A, Schopf E, Kapp A. Induction of intercellular adhesion molecule 1 (ICAM-1) expression in normal human eosinophils by inflammatory cytokines. J Invest Dermatol 1993; 100: 417-423.
31. Luttmann W, Opfer A, Dauer E, et al. Differential regulation of CD95 (Fas/APO-1) expression in human blood eosinophils. Eur J Immunol 1998; 28: 2057-2065.
32. Ochial K, Iwamoto I, Takahashi H, Yoshida S, Tomioka H, Yoshida S. Effect of IL-4 and interferon-gamma (IFN-gamma) on IL-3- and IL-5-induced eosinophil differentiation from human cord blood mononuclear cells. J Clin Exp Immunol 1995; 199: 124-128.
33. Takagi M, Kolke K, Nakahata T. Antiproliferative effect of IFN-gamma on proliferation of mouse connective tissue-type mast cells. J Immunol 1990; 145: 1880-1884.
34. Nafziger J, Arock M, Guillosson JJ, Wietzerbin J. Specific high-affinity receptors for interferon-gamma on mouse bone marrow-derived mast cells: inhibitory effect of interferon-gamma on mast cell precursors. Eur J Immunol 1990; 20: 113-117.
35. Manetti R, Parronchi P, Giudizi MG, et al. Natural killer cell stimulatory factor (Interleukin 12 [IL-12]) induces T helper type 1 (Th1) specific immune responses and inhibits the development of M-4-producing Th cells. J Exp Med 1993; 177: 1199-1204.
36. Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997; 185: 817-824.
37. Renzi PM, al Assaad AS, Yang J, Yasruel Z, Hamid Q. Cytokine expression in the presence or absence of late airway responses after antigen challenge of sensitized rats. Am J Respir Cell Mol Biol 1996; 15: 367-373.
38. Robinson DS, Tsicopoulos A, Meng Q, Durham S, Kay AB, Hamid Q. Increased interleukin 10 messenger RNA expression in atopic allergy and asthma. Am J Respir Cell Mol Biol 1996; 14: 113-117.
39. Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. Allergy Clin Immunol 1993; 92: 313-324.
40. Nagasawa H, Miyaura Q, Abe E, Suda T, Horiguchi M, Suda T. Fusion and activation of human alveolar macrophages induced by recombinant interferon-gamma and their suppression by dexamethasone. Am Rev Respir Dis 1987; 136: 916-921.