H-89 inhibits transient outward and inward rectifier potassium currents in isolated rat ventricular myocytes

British Journal of Pharmacology

Volumn 148, Issue 8, 2006, Pages 1091-1098

  Pearman, Charles ^a   Kent, William ^a   Bracken, Nicolas ^a   Hussain, Munir ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

H 89; K + currents; Myocytes; Phosphorylation; PKA

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALYCULIN A; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENZYME INHIBITOR; ISOPRENALINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHATASE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG MECHANISM; HEART MUSCLE CELL; HEART VENTRICLE WALL; HYPERPOLARIZATION; INWARD RECTIFIER POTASSIUM CURRENT; MALE; NONHUMAN; OUTWARD RECTIFIER POTASSIUM CURRENT; PHOSPHORYLATION; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RAT STRAIN; STEADY STATE; TIME; VOLTAGE CLAMP;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEART VENTRICLES; ION CHANNEL GATING; ISOQUINOLINES; MALE; PHOSPHORYLATION; POTASSIUM CHANNELS; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; SULFONAMIDES;

EID: 33747122673     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706810     Document Type: Article

References (24)

1. BLASEV, R., HUSSAIN, M., BAKKER, A.J., HEAD, S.I. & LAMB, G.D. (2001). Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres. J. Muscle Res. Cell. Motil., 22, 277-286.
2. CHIJIWA, T., MISHIMA, A., HAGIWARA, M., SANO, M., HAYASHI, K., INOUE, T., NAITO, K., TOSHIOKA, T. & HIDAKA, H. (1990). Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem., 265, 5267-5272.
3. CHOI, J., CHOI, B.H., HAHN, S.J., YOON, S.H., MIN, D.S., JO, Y. & KIM, M. (2001). Inhibition of Kv1.3 channels by H-89 (N-[2-(pbromocinnamylamino) ethyl]-5-isoquinolinesulfonamide) independent of protein kinase A. Biochem. Pharmacol., 61, 1029-1032.
4. CHORVATOVA, A. & HUSSAIN, M. (2003). Effects of caffeine on potassiumc urrents in isolated rat ventricular myocytes. Pflugers Arch., 446, 422-428.
5. DART, C. & LEYLAND, M.L. (2001). Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J. Biol. Chem., 276, 20499-20505.
6. K by guanine nucleotides and isoproterenol. Am. J. Physiol., 262, H1298-H1302.
7. + conductance in cardiac purkinje fibres. Nature, 306, 691-693.
8. + current via a cAMP/PKA-mediated pathway in the rat heart. Am. J. Physiol., 288, C577-C585.
9. HIDAKA, H. & KOBAYASHI, R. (1992). Pharmacology of protein kinase inhibitors. Annu. Rev. Pharmacol. Toxicol., 32, 377-397.
10. + regulation in isolated ferret ventricular myocytes. Pflugers Arch., 437, 529-537.
11. IIJIMA, T., IMAGAWA, J. & TAIRA, N. (1990). Differential modulation by beta adrenoceptors of inward calciuman d delayed rectifier potassiumcu rrent in single ventricular cells of guinea pig heart. J. Pharmacol. Exp. Ther., 254, 142-146.
12. ISHIHARA, H., MARTIN, B.L., BRAUTIGAN, D.L., KARAKI, H., OZAKI, H., KATO, Y., FUSETANI, N., WATABE, S., HASHIMOTO, K. & UEMURA, D. (1989). Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun., 159, 871-877.
13. + channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system. Circulation, 106, 1493-1499.
14. + channel function and phosphorylation in guinea-pig ventricle. J. Physiol., 486, 661-678.
15. K, by isoprenaline in rabbit isolated pacemaker cells. Exp. Physiol., 85, 27-35.
16. to) in normal and diseased myocardium. J. Mol. Cell. Cardiol., 33, 851-872.
17. to" phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J. Physiol., 569, 7-39.
18. ROSSIE, S. (1999). Regulation of voltage-sensitive sodium and calcium channels by phosphorylation. Adv. Sec. Mess. Phospho. Res., 33, 23-48.
19. SNYDERS, D.J. (1999). Structure and function of potassium channels. Cardiovasc. Res., 42, 377-390.
20. TAMARGO, J., CABALLERO, R., GOMEZ, R., VALENZUELA, C. & DELPON, E. (2004). Pharmacology of cardiac potassium channels. Cardiovasc. Res., 62, 9-33.
21. + current is not blocked by beta and alpha adrenergic blockers. Biophys. J., 58, 791-795.
22. 2+ channels. Cardiovasc. Res., 65, 28-39.
23. 2+ currents, and action potentials of rats. Am. J. Hypertens., 12, 1232-1240.
24. Kir2.2 is upregulated by activation of protein kinase A. Cardiovasc. Res., 63, 520-527.