Formation of tissue factor-factor VIIa-factor Xa complex prevents apoptosis in human breast cancer cells

Thrombosis and Haemostasis

Volumn 96, Issue 2, 2006, Pages 196-201

  Jiang, Xiaofeng ^a   Guo, Yan Lin ^b   Bromberg, Michael E ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b The University of Southern Mississippi   (United States)

Author keywords

Apoptosis; Breast cancer; Factor VIIa; Factor Xa; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; DNA FRAGMENT; HIRUDIN; HISTONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SURVIVIN; THROMBIN; THROMBOPLASTIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL LEVEL; CELL STRAIN MCF 7; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR VIIA; FACTOR XA; HUMANS; PHOSPHORYLATION; RECOMBINANT PROTEINS; THROMBOPLASTIN; TIME FACTORS;

EID: 33747122295     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-1-0057     Document Type: Article

References (29)

1. Nemerson Y. Tissue factor and hemostasis. Blood 1988; 71:1-8.
2. Konigsberg W, Kirchhofer D, Riederer MA, et al. The TF:VIIa complex: Clinical significance, structure-function relationships and its role in signaling and metastasis. Thromb Haemost 2001; 86: 757-71.
3. Callander NS, Varki N, Rao LVM. Immunohistochemical identification of tissue factor in solid tumors. Cancer 1992; 70: 1194-201.
4. Bromberg ME, Konigsberg WH, Madison JF, et al. Tissue factor promotes metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 1995; 92: 8205-9.
5. Bromberg ME, Sundaram R, Homer RJ, et al. Role of tissue factor in metastasis: function of the cytoplasmic and extracellular domains of the molecule. Thromb Haemost 1999; 82: 88-92.
6. Mueller BM, Ruf W. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. J Clin Invest 1998; 101: 1372-78.
7. Sturm U, Luther T, Albrecht S, et al. Immunohistochemical detection of tissue factor in normal and abnormal human mammary glands using monoclonal antibodies. Virchows Archiv A Pathol Anat 1992; 421: 79-86.
8. Vrana JA, Stang MT, Grande JP, et al. Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: Paracrine regulation by carcinoma cell-derived members of the transforming growth factor βfamily. Cancer Res 1996; 56: 5063-70.
9. Kirschmann DA, Seftor EA, Nieva DR, et al. Differentially expressed genes associated with the metastatic phenotype in breast cancer. Breast Cancer Res Treatment 1999; 55: 127-36.
10. Hu T, Bach RR, Horton R, et al. Procoagulant activity in cancer cells is dependent on tissue factor expression. Oncology Res 1994; 6: 321-7.
11. Jiang X, Bailly MA, Panetti T, et al. Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells. J Thromb Haemost 2004; 2: 93-101.
12. Hjortoe GM, Petersen LC, Albrektsen T, et al. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood 2004; 103: 3029-37.
13. Sorensen BB, Rao LV, Tornehave D, et al. Antiapoptotic effect of coagulation factor VIIa. Blood 2003; 102: 1708-15.
14. Versteeg HH, Spek CA, Richel DJ, et al. Coagulation factors VIIa and Xa inhibit apoptosis and anoikis. Oncogene 2004; 23: 410-7.
15. Guo YL, Wang S, Colman RW. Kininostatin, an antiangiogenic inhibitor, inhibits proliferation, and induces apoptosis of human endothelial cells. Arteriscler Throm Vasc Biol 2001; 21: 1427-33.
16. Kennedy SG, Wagner AJ, Conzen SD, et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 1997: 11: 701-13.
17. Zain J, Huang YQ, Feng X, et al. Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells. Blood 2000; 95: 3133-8.
18. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-6.
19. Dai C, Krantz SB. Interferon gamma induces up-regulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells. Blood 1999; 93: 3309-16.
20. Chen JS, Konopleva M, Andreeff M, et al. Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis. J. Cell Physiol 2004; 200: 223-34.
21. Ambrosini G, Adida C, Altieri DC. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997; 3: 917-21.
22. Altieri DC. Molecular circuits of apoptosis regulation and cell division control: the survivin paradigm. J Cell Biochem 2004; 92: 656-63.
23. Camerer E, Huang W, Coughlin SR. Tissue factor-and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000; 97: 5255-60.
24. Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001; 98: 7742-7.
25. Dan HC, Jiang K, Coppola D, et al. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene 2004; 23: 706-15.
26. Versteeg HH, Spek CA, Slofstra SH, et al. FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production. Circ Res 2004; 94: 1032-40.
27. Siegbahn A, Johnell M, Sorensen BB, et al. Regulation of chemotaxis by the cytoplasmic domain of tissue factor. Thromb Haemost 2005: 93: 27-34.
28. Ott I, Weigand B, Michl R, et al. Tissue factor cytoplasmic domain stimulates migration by activation of the GTPase Rac1 and the mitogen-activated protein kinase p38. Circulation 2005; 111: 349-55.
29. Belting M, Dorrell MI, Sandgren S, et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 2004; 10: 502-9.