Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 1, 2004, Pages 93-101

  Jiang, X ^a   Bailly, M A ^b   Panetti, T S ^a   Cappello, M ^b   Konigsberg, W H ^c   Bromberg, Michael E ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Breast cancer; Cellular migration; Cellular signaling; Factor VIIa; Factor Xa; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; BREAST CANCER; CANCER CELL CULTURE; CELL MIGRATION; CHEMOTAXIS; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION; BIOSYNTHESIS; BREAST TUMOR; CELL MOTION; FEMALE; GENE EXPRESSION; GENETICS; MACROMOLECULE; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; FACTOR VIIA; FACTOR XA; FEMALE; GENE EXPRESSION; HUMANS; MACROMOLECULAR SUBSTANCES; MAP KINASE SIGNALING SYSTEM; RECEPTOR, PAR-1; RECEPTOR, PAR-2; SIGNAL TRANSDUCTION; THROMBOPLASTIN;

EID: 3342972815     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2004.00545.x     Document Type: Article

References (36)

1. Nemerson Y. Tissue factor and hemostasis. Blood 1988; 71: 1-8.
2. Bromberg ME, Cappello M. Cancer and blood coagulation: molecular aspects. Cancer J Sci Am 1999; 5: 132-8.
3. Konigsberg W, Kirchhofer D, Riederer MA, Nemerson Y. The TF:VIIa complex: clinical significance, structure-function relationships and its role in signaling and metastasis. Thromb Haemost 2001; 86: 757-71.
4. Bromberg ME, Konigsberg WH, Madison JF, Pawashe A, Garen A. Tissue factor promotes metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 1995; 92: 8205-9.
5. Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of tissue factor in metastasis: function of the cytoplasmic and extra-cellular domains of the molecule. Thromb Haemost 1999; 82 88-92.
6. Mueller BM, Ruf W. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. J Clin Invest 1998; 101: 1372-8.
7. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem 1996; 271: 29034-42.
8. Sorensen BB, Fresgarkgard PO, Nielson LS, Rao LVM, Ezban M, Petersen LC. Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain. J Biol Chem 1999; 274: 21349-54.
9. Versteeg HH, Hoedemaeker I, Diks SH, Stam JC, Spaargaren M, van Bergen en Henegouwen PMP, van Deventer SJH, Peppelenbosch MP. Factor VIIa/tissue factor-induced signaling via activation of src-like kinases, phosphatidylinositol 3-kinase, and rac. J Biol Chem 2000; 275 28750-6.
10. Camerer E, Rottingen J-A, Gjernes E, Larsen K, Skartlien AH, Iversen J-G, Prydz H. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene. J Biol Chem 1999; 274: 32225-33.
11. Pendurthi UR, Allen KE, Ezban M, Rao LVM. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible down-stream mediators in factor VIIa-tissue factor-induced signal transduction. J Biol Chem 2000; 275: 14632-41.
12. Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000; 97: 5255-60.
13. Coughlin SR. Protease-activated receptors in vascular biology. Thromb Haemost 2001; 86: 298-307.
14. Petersen LC, Thasrup O, Hagel G, Sorensen BB, Fesgard PO, Rao LVM, Ezban M. Exclusion of known protease activated receptors in factor VIIa-induced signal transduction. Thromb Haemost 2000; 83: 571-6.
15. Callander NS, Varki N, Rao LVM. Immunohistochemical identification of tissue factor in solid tumors. Cancer 1992; 70 1194-201.
16. Nierodzik MLR, Bain RM, Lin LX, Shivji M, Takeshita K, Karpatkin S. Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumour tyrosine phosphorylation. Br J Haematol 1996; 92: 452-7.
17. Miyata S, Koshikawa N, Yasumitsu H, Miyazaki K. Trysin stimulates integrin α5β1-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2. J Biol Chem 2000; 275: 4592-8.
18. Bromberg ME, Bailly MA, Konigsberg WH. Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor. Thromb Haemost 2001; 86: 1210-4.
19. Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, Ginzburg Y, Reich R, Vlodavsky I, Bar-Shavit R. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 1998; 4: 909-14.
20. Nierodzik ML, Chen K, Takeshita K, Li JJ, Huang YQ, Feng XS, D'Andrea MR, Andrade-Gordon P, Karpatkin S. Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin enhanced experimental pulmonary metastasis. Blood 1998; 92: 3649-700.
21. Cappello M, Hawdon JM, Jones BF, Kennedy WP, Hotez PJ. Ancylostoma caninum anticoagulant peptide: cloning by PCR and expression of soluble, active protein in E. coli. Molec Biochem Parasitol 1996; 80: 113-7.
22. Thompson EW, Paik S, Brunner N, Sommers CL, Zugmaier G, Clarke R, Sima TB, Torri J, Donahue S, Lippman ME, Martin GR, Dickson RB. Association of increased basement membrane with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol 1992; 150: 534-44.
23. Hu T, Bach RR, Horton R, Konigsberg WH, Todd MB. Procoagulant activity in cancer cells is dependent on tissue factor expression. Oncol Res 1994; 6: 321-7.
24. Belham CM, Tate RJ, Scott PH, Scott PH, Pemberton AD, Miller HR, Wadsworth RM, Gould GW, Plevin R. Trypsin stimulates protease-activated receptor-2 dependent and independent of mitogen-activated protein kinases. Biochem J 1996; 320: 939-46.
25. Poulsen LK, Jacobsen N, Sorensen BB, Bergenhem NC, Kelly JD, Foster DC, Thastrup O, Ezban M, Petersen LC. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor. J Biol Chem 1998; 273 6228-32.
26. Donnelly KM, Bromberg ME, Milstone A, McNiff J, Terwilliger G, Konigsberg WH, Cappello M. Ancylostoma cainum anticoagulant peptide blocks metastasis in vivo and inhibits Xa binding to melanoma cells in vitro. Thromb Haemost 1998; 79: 1041-7.
27. Vlasuk GP. Structural and functional characterization of tick anticoagulant peptide (TAP): a potent and selective inhibitor of blood coagulation factor Xa. Thromb Haemost 1993; 70: 212-6.
28. O'Brien PJ, Prevost N, Molino M, Holllinger MK, Woolkalis MJ, Woulfe DS, Brass LF. Thrombin responses in human endothelial cells. Contributions from receptor other than PAR1 include transactivation of PAR2 by thrombin-cleaved PAR1. J Biol Chem 2000; 275: 13502-9.
29. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM. Indentification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 1998; 273 18623-32.
30. Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001; 98: 7742-7.
31. Siegbahn A, Johnell M, Rorsman C, Ezban M, Heldin CH, Ronnstrand L. Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phopholipase C and enhanced PDGF-BB-stimulated chemotaxis. Blood 2000; 96: 3452-8.
32. Kamath L, Meydani A, Foss F, Kuliopulos A. Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res 2001; 61: 5933-40.
33. Zhang X, Liu Y, Gilcrease MZ, Yuan XH, Clayman GL, Adler-Storthz K, Chen Z. A lymph node metastastic mouse mode reveals alterations of metastasis-related gene expression in metastatic oral carcinoma sublines selected from a poorly metastatic parental cell line. Cancer 2002; 95: 1663-72.
34. Klemke RL, Cai S, Giannini AL, Gallagher PJ, de Lanerolle P, Cheresh DA. Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol 1997; 137: 481-92.
35. Kirschmann DA, Seftor EA, Nieva DRC, Mariano EA, Hendrix MJC. Differentially expressed genes associated with the metastatic phenotype in breast cancer. Breast Cancer Res Treat 1999; 55: 127-36.
36. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 1999; 103: 879-87.