Protein phosphorylation profile and adduct formation in liver and kidney of microcystin-LR-treated mice

Toxicon

Volumn 48, Issue 3, 2006, Pages 272-277

  Jayaraj, R ^a   Lakshmana Rao, P V ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Microcystin adduct; Microcystin LR; Protein phosphatase

Indexed keywords

CYANOGINOSIN LR; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; THREONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; FEMALE; IN VIVO STUDY; KIDNEY; LD 50; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; KIDNEY; LIVER; MICE; MICROCYSTINS; PEPTIDES, CYCLIC; PHOSPHORYLATION;

EID: 33746995041     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2006.05.012     Document Type: Article

References (20)

1. Carmichael W.W., Azevedo S.M.F.O., An J.S., Molica R.J.R., Jochimsen E.M., Lau S., Rinehart K.L., Shaw G.R., and Eaglesham G.K. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environ. Health Perspect. 109 (2001) 663-668
2. Chorus I., Falconer I.R., Salas H.J., and Batram J. Health risks caused by freshwater cyanobacteria in recreational waters. J. Toxicol. Environ. Health 3 (2000) 323-347
3. Craig M., Luu H.A., McCready T.L., Williams D., Andersen R.J., and Holmes C.F. Molecular mechanisms underlying the interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases. Biochem. Cell Biol. 74 (1996) 569-578
4. Eriksson J.E., Toivola D., Meriluoto J.A.O., Karaki H., Han Y.-G., and Hartshorne D. Hepatocyte deformation induced by cyanobacterial toxin reflects inhibition of protein phosphatases. Biochem. Biophys. Res. Commun. 173 (1990) 1347-1353
5. Honkanen R.E., and Golden T. Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?. Current Med. Chem. 9 (2002) 1967-1987
6. Ito E., Takai A., Kondo F., Masui H., Imanishi S., and Harada K.-I. Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 40 (2002) 1017-1025
7. Janssens V., and Goris J. Protein phosphatases 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353 (2001) 417-439
8. Kondo F., Matsumoto H., Yamada S., Ishiwaka N., Ito E., Nagata S., Ueno Y., Suzuki M., and Harada K.-I. Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers. Chem. Res. Toxicol. 9 (1996) 1355-1359
9. Liu B.H., Yu F.Y., Huang X., and Chu F.S. Monitoring of microcystin protein phosphatase adduct formation with immunochemical methods. Toxicon 38 (2000) 619-632
10. Mackintosh C., Beattie K.A., Klumpp S., Cohen P., and Codd G.A. Cyanobacterial toxin microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264 (1990) 187-192
11. Meriluoto J., Nygard S.E., Dahlem A.M., and Eriksson J.E. Synthesis, organotropism and hepatocellular uptake of tritium labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog. Toxicon 28 (1990) 1439-1446
12. Mountfort D.O., Kennedy G., Garthwaite I., Quilliam M., Truman P., and Hannah D.J. Evaluation of the fluorometric protein phosphatase inhibition assay in the determination of okadaic acid in the mussels. Toxicon 37 (1999) 909-922
13. Nidhi G., Pant S.C., Vijayaraghavan R., and Lakshmana Rao P.V. Comparative toxicity evaluation of cyanobacterial peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 188 (2003) 285-296
14. Nobre A.C.L., Coelho G.R., Coutinho M.C.M., Silva M.M., Angelim E.V., Menezes D.B., Fonteles M.C., and Monterio H.S.A. The role of phospholipase A2 and cyclooxigenase in renal toxicity induced by microcystin-LR. Toxicon 39 (2001) 721-724
15. Rao P.V.L., and Bhattacharya R. The cyanobacterial toxin microcystin-LR induced DNA damage in mouse liver in vivo. Toxicology 114 (1996) 29-36
16. Rao P.V.L., Jayaraj R., and Bhaskar A.S.B. Protective efficacy and the recovery profile of certain chemoprotectants against lethal poisoning by microcystin-LR in mice. Toxicon 44 (2004) 723-730
17. Runnegar M., Berndt N., Kong S.M., Lee E.Y.C., and Zhang L. In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A. Biochem. Biophys. Res. Commun. 216 (1995) 162-169
18. Stotis R.S., Namikoshi M., Haschecck W.M., Rinehart K.L., Carmichael W.W., Dahlem A.M., and Beasley V.R. Structural modifications imparting reduced toxicity in microcystins from Microcystis spp. Toxicon 31 (2000) 783-789
19. Toivola D.M., Eriksson J.E., and Brautigan D.L. Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates. FEBS Lett. 344 (1994) 175-180
20. Yu S.Z. Primary prevention of hepatocellular carcinoma. J. Gastroenterol. Hepatol. 10 (1995) 674-682