Protective efficacy and the recovery profile of certain chemoprotectants against lethal poisoning by microcystin-LR in mice

Toxicon

Volumn 44, Issue 7, 2004, Pages 723-730

  Rao, P V Lakshmana ^a   Jayaraj, R ^a   Bhaskar, A S B ^a  

^a Div of Pharmacology and Toxicology   (India)

Author keywords

Antidotes; Cyanobacterial toxin; Cyclosporin A; Microcystin LR; Rifampin; Silymarin

Indexed keywords

ALANINE AMINOTRANSFERASE; CYANOGINOSIN LR; CYCLOSPORIN A; GLUTATHIONE; IDITOL DEHYDROGENASE; LACTATE DEHYDROGENASE; PHOSPHATASE; RIFAMPICIN; SILYMARIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD ANALYSIS; CONTROLLED STUDY; CYANOBACTERIUM; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; IMMUNOBLOTTING; LIPID PEROXIDATION; LIVER FUNCTION; LIVER HOMOGENATE; NONHUMAN; PRIORITY JOURNAL; TOXEMIA;

ALANINE TRANSAMINASE; ANIMALS; BACTERIAL TOXINS; BLOTTING, WESTERN; CYANOBACTERIA; CYCLOSPORINE; FEMALE; GLUTATHIONE; L-IDITOL 2-DEHYDROGENASE; L-LACTATE DEHYDROGENASE; LIVER; MICE; MICROCYSTINS; PEPTIDES, CYCLIC; PHOSPHOPROTEIN PHOSPHATASE; PROTECTIVE AGENTS; RIFAMPIN; SILYMARIN; SPECTROMETRY, FLUORESCENCE;

ANIMALIA; CYANOBACTERIA;

EID: 6944251909     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.07.010     Document Type: Article

References (26)

1. W.H. Adams, R.D. Stoner, D.G. Adams, H. Read, D.N. Slatkin, and H.W. Siegelman Prophylaxis of cyanobacterial and mushroom cyclic peptide toxins J. Pharmacol. Exp. Ther. 1 249 1989 552 556
2. S.M.F.O. Azevedo, W.W. Carmichael, E.M. Jochimsen, K.L. Rinehart, S. Lau, G.R. Shaw, and G.K. Eaglesham Human intoxication by microcystins during renal dialysis treatment in Caruaru-Brazil Toxicology 181/182 2002 441 446
3. S.G. Bell, and G.A. Codd Cyanobacterial toxins and human health Rev. Med. Microbiol. 5 1994 256 264
4. I. Chorus, I.R. Falconer, H.J. Salas, and J. Batram Health risks caused by freshwater cyanobacteria in recreational waters J. Toxicol. Environ. Health 3 2000 323 347
5. R.M. Dawson Toxicology of microcystins Toxicon 7 1998 953 962
6. W.X. Ding, and C.N. Ong Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity FEMS Microbiol. Lett. 220 2003 1 7
7. J.E. Eriksson, D. Toivola, J.A.O. Meriluoto, H. Karaki, Y.-G. Han, and D. Hartshorne Hepatocyte deformation induced by cyanobacterial toxin reflects inhibition of protein phosphatases Biochem. Biophys. Res. Commun. 173 1990 1347 1353
8. S.J. Hermansky, P.J. Casey, and S.J. Stohs Cyclopsorin-A a chemoprotectant against microcystin-LR toxicity Toxicol. Lett. 54 1990 279 285
9. S.J. Hermansky, S.J. Stohs, Z.M. Eldeen, V.F. Roche, and K.A. Mereish Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice J. Appl. Toxicol. 11 1991 65 74
10. P.J. Hisin, and R. Hilf A fluorometric method for determination of oxidised and reduced glutathione in tissues Anal. Biochem. 74 1976 214 226
11. B.C. Hitzfeld, S.J. Höger, and R. Dietrich Cyanobacterial toxins: removal during drinking water treatment, and human risk assessment Environ. Health Perspect. 10 2000 113 122
12. F. Kondo, H. Matsumoto, S. Yamada, N. Ishikawa, E. Ito, S. Nagata, Y. Ueno, M. Suzuki, and K. Harada Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers Chem. Res. Toxicol. 9 1996 1355 1359
13. O.H. Lowry, N.J. Rosenberg, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
14. D.O. Mountfort, G. Kennedy, I. Garthwaite, M. Quilliam, P. Truman, and D.J. Hannah Evaluation of the fluorometric protein phosphatase inhibition assay in the determination of okadaic acid in the mussels Toxicon 37 1999 909 922
15. Nidhi G., 2002. Evaluation of Toxicity and Screening of Antidotes of Cyanobacterial Toxins. PhD Thesis. Jiwaji University, Gwalior, India.
16. G. Nidhi, S.C. Pant, R. Vijayaraghavan, and P.V. Lakshmana Rao Comparative toxicity evaluation of cyanobacterial peptide toxin microcystin variants (LR, RR, YR) in mice Toxicology 188 2003 285 296
17. R. Nishiwaki-Matsushima, T. Ohta, S. Nishiwaki, M. Suganuma, K. Kohyama, T. Ishiwaka, W.W. Carmichael, and H. Fujiki Liver tumour promotion by the cyanobacterial cyclic peptide toxin microcystin-LR J. Cancer Res. Clin. Oncol. 118 1992 420 424
18. A.C.L. Nobre, A.M.C. Martins, A. Havt, C. Benevides, A.A.M. Lima, M.C. Fonteles, and H.S.A. Monteiro Renal effects of supernatant from rat peritoneal macrophages activated by microcystin-LR: role protein mediators Toxicon 41 2003 377 381
19. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
20. P.V.L. Rao, and R. Bhattacharya The cyanobacterial toxin microcystin-LR induced DNA damage in mouse liver in vivo Toxicology 114 1996 29 36
21. P.V.L. Rao, R. Bhattacharya, M.M. Parida, A.M. Jana, and A.S.B. Bhaskar Freshwater cyanobacterium Microcystis aeruginosa (UTEX 2385) induced DNA damage in vivo and in vitro Environ. Toxicol. Pharmacol. 5 1998 1 6
22. M. Runnegar, N. Berndt, S.M. Kong, E.Y.C. Lee, and L. Zhang In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A Biochem. Biophys. Res. Commun. 216 1995 162 169
23. M. Runnegar, N. Berndt, and N. Kaplowitz Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to hepatic transporters Toxicol. Appl. Pharmacol. 134 1995 264 272
24. D.M. Toivola, J.E. Eriksson, and D.L. Brautigan Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates FEBS Lett. 344 1994 175 180
25. S.Z. Yu Primary prevention of hepatocellular carcinoma J. Gastroenterol. Hepatol. 10 1995 674 682
26. L. Zhan, M. Sakamoto, D-S. Wu, L.-S. Zhang, T. Suzuki, M. Hayashi, and M. Honma Genotoxicity of microcystin-LR in human lymphoblastoid TK 6 cells Mutat. Res. 557 2004 1 6