Subtle differences in HLA DQ haplotype-associated presentation of AChR α-chain peptides may suffice to mediate myasthenia gravis

Autoimmunity

Volumn 39, Issue 4, 2006, Pages 277-288

  Deitiker, Philip R ^a   Oshima, Minako ^a   Smith, R Glenn ^b   Mosier, Dennis R ^a,c   Atassi, M Zouhair ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acetylcholine receptor; Autoimmunity; HLA; Myasthenia gravis; T cell

Indexed keywords

CHOLINERGIC RECEPTOR; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN;

ADOLESCENT; ADULT; AGED; ALLELE; ALPHA CHAIN; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE LOCUS; HAPLOTYPE; HLA TYPING; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MYASTHENIA GRAVIS; ONSET AGE; PROTEIN DOMAIN; SCHOOL CHILD; STATISTICAL SIGNIFICANCE; STUDENT T TEST; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ALLELES; AMINO ACID SEQUENCE; FEMALE; GENOTYPE; HAPLOTYPES; HLA-DQ ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MYASTHENIA GRAVIS; PROTEIN SUBUNITS; RECEPTORS, CHOLINERGIC; T-LYMPHOCYTES;

EID: 33746947302     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930600738581     Document Type: Article

References (38)

1. Appel, SH and Almon, RR and Levy, N. (1975) Acetylcholine receptor antibodies in myasthenia gravis N Engl J Med, 293, pp. 760-761.
2. Lindstrom, JM and Seybold, ME and Lennon, VA and Whittingham, S and Duane, DD. (1976) Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value Neurology, 26, pp. 1054-1059.
3. Vincent, A. (2002) Unravelling the pathogenesis of myasthenia gravis Nat Rev Immunol, 2, pp. 797-804.
4. Hohlfeld, R and Toyka, KV and Tzartoss, SJ and Carson, W and Conti-Tronconi, B. (1987) Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor α subunit Proc Natl Acad Sci USA, 84, pp. 5379-5383.
5. Ofosu-Appiah, W and Mokhtarian, F and Shirazian, D and Grob, D. (1994) Production of anti-acetylcholine receptor-α antibody in vitro by peripheral blood lymphocytes of patients with myasthenia gravis: Role of immunoregulatory T cells and monocytes J Lab Clin Med, 124, pp. 231-241.
6. Rosenberg, JS and Oshima, M and Atassi, MZ. (1996) B-cell activation in vitro by helper T cells specific to region α146-162 of Torpedo californica nicotinic acetylcholine receptor J Immunol, 157, pp. 3192-3199.
7. Yokoi, T and Mulac-Jericevic, B and Kurisaki, J and Atassi, MZ. (1987) T lymphocyte recognition of acetylcholine receptor: Localization of the full T-cell recognition profile on the extracellular part of the α chain of Torpedo californica acetylcholine receptor Eur J Immunol, 17, pp. 1697-1702.
8. Oshima, M and Ashizawa, T and Pollack, MS and Atassi, MZ. (1990) Autoimmune T cell recognition of human acetylcholine receptor: The sites of T cell recognition in myasthenia gravis on the extracellular part of the α subunit Eur J Immunol, 20, pp. 2563-2569.
9. Kanai, T and Nomura, Y and Segawa, M and Takagi, K and Senju, S and Matsushita, S and Nishimura, Y. (1997) Immuno-suppressive peptides for a human T cell clone autoreactive to a unique acetylcholine receptor alpha subunit peptide presented by the disease-susceptible HLA-DQ6 in infant-onset myasthenia gravis Hum Immunol, 56, pp. 28-38.
10. Wang, Z-Y and Diethelm-Okita, B and Okita, DK and Kaminski, HJ and Howard, JF and Conti-fine, B. (2000) T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis J Neuroimmunol, 108, pp. 29-39.
11. Oshima, M and Deitiker, PR and Mosier, DR and Smith, RG and Atassi, MZ. (2005) Responses in vitro of peripheral blood lymphocytes from patients with myasthenia gravis to stimulation with human AChR α-chain peptides: Analysis in relation to age, thymic abnormality and ethnicity Hum Immunol, 66, pp. 32-42.
12. Zhang, Y and Schleup, M and Frutiger, S and Hughes, GJ and Jeannet, M and Steck, A and Barkas, T. (1990) Immunological heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenia patients Eur J Immunol, 20, pp. 2577-2583.
13. Nagvekar, N and Corlett, L and Jacobson, LW and Matsuo, H and Chalkley, R and Driscoll, PC and Deshpande, S and Spack, EG and Willcox, N. (1999) Scanning a DRB3*0101 (DR52a)-restricted epitope cross-presented by DR3: Overlapping natural and artificial determinants in the human acetylcholine receptor J Immunol, 162, pp. 4079-4087.
14. Berrih-Aknin, S and Cohen-Kaminsky, S and Lepage, V and Neumann, D and Bach, JF and Fuchs, S. (1991) T-cell antigenic sites involved in myasthenia gravis: Correlation with antibody titre and disease severity J Autoimmun, 4, pp. 137-153.
15. Nishimura, Y and Kanai, T and Oiso, M and Tabata, H and Ito, H and Kira, J and Chen, Y-Z and Matsushita, S. (1998) Molecular analysis of HLA class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians Int J Cardiol, 1(66 Suppl), pp. S93-104.
16. Manfredi, AA and Yuen, MH and Moiola, L and Protti, MP and Conti-Tronconi, BM. (1994) Human acetylcholine receptor presentation in myasthenia gravis. DR restriction of autoimmune T epitopes and binding of synthetic receptor sequences to DR molecules J Immunol, 152, pp. 4165-4174.
17. Horiki, T and Inoko, H and Moriuchi, J and Ichikawa, Y and Arimori, S. (1994) Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan Autoimmunity, 19, pp. 49-54.
18. Shinomiya, N and Nomura, Y and Segawa, M. (2004) A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan Clin Immunol, 110, pp. 154-158.
19. Garchon, HJ. (2003) Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man J Autoimmun, 21, pp. 105-110.
20. Matsuki, K and Juji, T and Tokunaga, K and Takamizawa, M and Maeda, H and Soda, M and Nomura, Y and Segawa, M. (1990) HLA antigens in Japanese patients with myasthenia gravis J Clin Invest, 86, pp. 392-399.
21. Khalil, I and Berrih-Aknin, S and Lepage, V and Loste, MN and Gajdos, P and Hors, J and Charron, D and Degos, L. (1993) Trans-encoded DQ alpha beta heterodimers confer susceptibility to myasthenia gravis disease C R Acad Sci III, 316, pp. 652-660.
22. Hjelmstrom, P and Giscombe, R and Lefvert, AK and Pirskanen, R and Kockum, I and Landin-Olsson, M and Sanjeevi, CB. (1995) Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis Autoimmunity, 22, pp. 59-65.
23. Vieira, ML and Caillat-Zucman, S and Gajdos, P and Cohen-Kaminsky, S and Casteur, A and Bach, J-F. (1993) Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis J Neuroimmunol, 47, pp. 115-122.
24. Baggi, F and Antozzi, C and Andreetta, F and Confaloniri, P and Ciusani, E and Begovich, AB and Erlich, HA and Cornelio, A and Mantegazza, R. (1998) Identification of a novel HLA class II association with DQB1*0502 in an Italian myasthenic population Ann NY Acad Sci, 841, pp. 355-359.
25. Hjelmstrom, P and Giscombe, R and Lefvert, AK and Pirskanen, R and Kockum, I and Landin-Olsson, M and Sanjeevi, CB. (1996) Polymorphic amino acid domains of the HLA-DQ molecules are associated with disease heterogeneity in myasthenia gravis J Neuroimmunol, 65, pp. 125-131.
26. Suzuki, S and Kuwana, M and Yasuoka, H and Tanaka, K and Fukuuchi, Y and Kawakami, Y. (2001) Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis J Neurol Sci, 189, pp. 59-64.
27. Pera, C and Delfino, L and Longo, A and Pistillo, MP and Ferrara, GB. (2000) Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT) Tissue Antigens, 55, pp. 275-279.
28. Oshima, M and Ohtani, M and Deitiker, PR and Smith, RG and Mosier, DR and Atassi, MZ. (2005) Suppression by mAbs against DQB1 peptides of in vitro proliferation of AChR-specific T cells from myasthenia gravis patients Autoimmunity, 38, pp. 161-169.
29. Olerup, O and Aldener, A and Fogdell, A. (1993) HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours Tissue Antigens, 41, pp. 119-134.
30. Zar, JH. (1996) Biostatistical Analysis 3rd ed. Englewood Cliffs, NJ: Prentice Hall.
31. Imanishi, T and Akaza, T and Kimura, A and Tokunaga, K and Gojobori, T. (1992) Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. In HLA 1991. (pp. 1065-1220). Oxford: Oxford Science Publications.
32. Tsuneto, LT and Probst, CM and Hutz, MH and Salzano, FM and Rodriguez-Delfin, LA and Zago, MA and Hill, K and Hurtado, AM and Ribeiro-dod-Santos, AKC and Petzl-Erler, ML. (2003) HLA class II diversity in seven Amerindian populations. Clues about the origins of the Ache Tissue Antigens, 62, pp. 512-526.
33. Gorodezky, C and Alaez, C and Vazquez-Garcia, MN and de la Rosa, G and Infante, E and Balladares, S and Toribio, R and Perez-Luque, E and Munoz, L. (2001) The genetic structure of Mexican Mestizos of different locations: Tracking back their origins through MHC genes, blood group systems, and microsatellites Hum Immunol, 62, pp. 979-991.
34. Hollenbach, JA and Thomson, G and Cao, K and Fernandez-Vina, M and Erlich, HA and Bugawan, TL and Winkler, C and Winter, M and Klitz, W. (2001) HLA diversity, differentiation, and haplotype evolution in Mesoamerican natives Hum Immunol, 6, pp. 378-390.
35. Alaez, C and Infante, E and Pujol, J and Duran, C and Navarro, JL and Gorodezky, C. (2002) Molecular analysis of HLA-DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico Tissue Antigens, 59, pp. 388-396.
36. Shenoy, M and Oshima, M and Atassi, MZ and Christadoss, P. (1993) Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region α146-162 of acetylcholine receptor Clin Immunol Immunopathol, 66, pp. 230-238.
37. Oshima, M and Pachner, AR and Atassi, MZ. (1994) Profile of the regions of acetylcholine receptor α chain recognized by T-lymphocytes and by antibodies in EAMG-susceptible and non-susceptible mouse strains after different periods of immunization with the receptor Mol Immunol, 31, pp. 833-843.
38. Noda, M and Furutani, Y and Takahashi, H and Toyosato, M and Tanabe, T and Shimizu, S and Kikyotani, S and Kayano, T and Hirose, T and Inayama, S and Numa, S. (1983) Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor Nature, 305, pp. 818-823.