Responses in vitro of peripheral blood lymphocytes from patients with myasthenia gravis to stimulation with human acetylcholine receptor α-chain peptides: Analysis in relation to age, thymic abnormality, and ethnicity

Human Immunology

Volumn 66, Issue 1, 2005, Pages 32-42

  Oshima, Minako ^a   Deitiker, Philip R ^a   Mosier, Dennis R ^a,b   Smith, R Glenn ^c   Atassi, M Zouhair ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

acetylcholine receptor; autoimmunity; myasthenia gravis; T cell

Indexed keywords

AZATHIOPRINE; CHOLINERGIC RECEPTOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; PYRIDOSTIGMINE; SYNTHETIC PEPTIDE;

ADULT; AFRICAN AMERICAN; AGE DISTRIBUTION; ARTICLE; CAUCASIAN; CELL ISOLATION; CELL PROLIFERATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ETHNOLOGY; FEMALE; HISPANIC; HUMAN; HUMAN TISSUE; MALE; MYASTHENIA GRAVIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STIMULATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; AUTOIMMUNITY; CONTINENTAL POPULATION GROUPS; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MYASTHENIA GRAVIS; PEPTIDE FRAGMENTS; PROTEIN SUBUNITS; RECEPTORS, CHOLINERGIC; T-LYMPHOCYTES;

EID: 11144256466     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2004.09.015     Document Type: Article

References (37)

1. S.H. Appel, R.R. Almon, N. Levy Acetylcholine receptor antibodies in myasthenia gravis N Engl J Med 293 1975 760
2. J.M. Lindstrom, M.E. Seybold, V.A. Lennon, S. Whittingham, D.D. Duane Antibody to acetylcholine receptor in myasthenia gravis prevalence, clinical correlates, and diagnostic value Neurology 26 1976 1054
3. R. Hohlfeld, I. Kalies, B. Kohleisen, K. Heininger, B. Conti-Tronconi, K.V. Toyka Myasthenia gravis stimulation of antireceptor autoantibodies by autoreactive T cell lines Neurology 36 1986 618
4. A. Melms, B.C.G. Schalke, T. Kirchner, H.K. Muller-Hermelink, E. Albert, H. Wekerle Thymus in myasthenia gravis isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients J Clin Invest 81 1988 902
5. K.A. Krolick, O.E. Urso Analysis of helper-T cell function by acetylcholine receptor-reactive cell lines of defined AChR-subunit specificity Cell Immunol 105 1987 75
6. D. Asthana, Y. Fujii, G.E. Huston, J. Lindstrom Regulation of antibody production by helper T cell clones in experimental autoimmune myasthenia gravis is mediated by IL-4 and antigen-specific T cell factors Clin Immunol Immunopathol 67 1993 240
7. W. Ofosu-Appiah, F. Mokhtarian, D. Shirazian, D. Grob Production of anti-acetylcholine receptor-α antibody in vitro by peripheral blood lymphocytes of patients with myasthenia gravis role of immunoregulatory T cells and monocytes J Lab Clin Med 124 1994 231
8. J.S. Rosenberg, M. Oshima, M.Z. Atassi B-cell activation in vitro by helper T cells specific to region α146-162 of Torpedo californica nicotinic acetylcholine receptor J Immunol 157 1996 3192
9. M. Oshima, M.Z. Atassi T cells of mice treated with mPEG-myasthenogenic peptide conjugate are involved in protection against EAMG by stimulating lower pathogenic antibody responses Autoimmunity 32 2000 45
10. S. Berrih-Aknin, S. Cohen-Kaminsky, D. Neumann, D. Safar, B. Eymard, C. Gaud, P. Levasseur, S. Fuchs, J.F. Bach Cellular aspects of myasthenia gravis Immunol Res 7 1988 189
11. R. Hohlfeld, H. Wekerle The role of thymus in myasthenia gravis Adv Neuroimmunol 4 1994 373
12. R. Hohlfeld, K.V. Toyka, S.J. Tzartoss, W. Carson, B. Conti-Tronconi Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor α subunit Proc Natl Acad Sci U S A 84 1987 5379
13. G.C. Harcourt, N. Sommer, J. Rothbard, H.N. Willcox, J. Newsom-Davis A juxta-membrane epitope on the human acetylcholine receptor recognized by T cells in myasthenia gravis J Clin Invest 82 1988 1295
14. S. Brocke, C. Brautbar, L. Steinman, O. Abramsky, J. Rothbard, D. Newmann, S. Fuchs, E. Mozes In vitro proliferative responses and antibody titers specific to human actylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes J Clin Invest 82 1988 1894
15. S. Berrih-Aknin, S. Cohen-Kaminsky, V. Lepage, D. Neumann, J.F. Bach, S. Fuchs T-cell antigenic sites involved in myasthenia gravis correlations with antibody titre and disease severity J Autoimmun 4 1991 137
16. H. Link, Z.-Y. Xu, A. Melms, H. Kalbacher, J.-B. Sun, Z.-Y. Wang, S. Fredrikson, T. Olsson The T-cell repertoire in myasthenia gravis involves multiple cholinergic receptor epitopes Scand J Immunol 36 1992 405
17. + T-epitope repertoire on the human acetylcholine receptor α subunit in severe myasthenia gravis a study with synthetic peptides Neurology 42 1992 1092
18. Z.-Y. Wang, D.K. Okita, J.F. Howard, B. Conti-Fine Th1 cells of myasthenia gravis patients recognize multiple epitopes on the muscle acetylcholine receptor α subunit Ann N Y Acad Sci 841 1998 329
19. M. Noda, Y. Furutani, H. Takahashi, M. Toyosato, T. Tanabe, S. Shimizu, S. Kikyotani, T. Kayano, T. Hirose, S. Inayama, S. Numa Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor Nature 305 1983 818
20. B. Mulac-Jericevic, T. Manshouri, T. Yokoi, M.Z. Atassi The regions of α-neurotoxin binding on the extracellular part of the α-subunit of human acetylcholine receptor J Prot Chem 7 1988 173
21. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America, et al. Myasthenia gravis recommendations for clinical research standards Neurology 55 2000 16
22. J.H. Zar Biostatistical Analysis 2nd ed. 1984 Prentice-Hall Englewood Cliffs, NJ
23. K. Okuda, S.S. Twining, C.S. David, M.Z. Atassi Genetic control of immune response to sperm whale myoglobin in mice. II. T lymphocyte proliferative response to the synthetic antigenic sites J Immunol 123 1979 182
24. M. Kuana, T.A. Medsger, T.M. Wright Highly restricted TCR-αβ usage by autoreactive human T cell clones specific for DNA topoisomerase I J Immunol 158 1997 485
25. S.L. Kirshner, A. Waisman, E. Zisman, A. Ben-Nun, E. Mozes T cell receptor expression and differential proliferative responses by T cells specific to a myasthenogenic peptide Cell Immunol 180 1997 20
26. A. Karni, E. Zisman, Y. Katz-Levy, M. Pass-Rozner, M. Dayan, C. Brautbar, O. Abramsky, M. Sela, E. Mozes Reactivity of T cells from seronegative patients with myasthenia gravis to T cell epitopes of the human acetylcholine receptor Neurology 48 1997 1638
27. M. Oshima, T. Ashizawa, M.S. Pollack, M.Z. Atassi Autoimmune T cell recognition of human acetylcholine receptor the sites of T cell recognition in myasthenia gravis on the extracellular part of the α subunit Eur J Immunol 20 1990 2563
28. Z.-Y. Wang, B. Diethelm-Okita, D.K. Okita, H.J. Kaminski, J.F. Howard, B. Conti-Fine T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis J Neuroimmunol 108 2000 29
29. M.P. Protti, A.A. Manfredi, C. Straub, J.F. Howard, B.M. Conti-Tronconi Immunodominant regions for T helper-cell sensitization on the human nicotinic receptor α subunit in myasthenia gravis Proc Natl Acad Sci U S A 87 1990 7792
30. B. Ong, N. Willcox, P. Wordsworth, D. Beeson, A. Vincent, D. Altman, J.S.S. Lanchbury, G.C. Harcourt, J.I. Bell, J. Newsom-Davis Critical role for the Val/Gly86 HLA-DRβ dimorphism in autoantigen presentation to human T cells Proc Natl Acad Sci U S A 88 1991 7343
31. N. Nagvekar, A.-M. Moody, P. Moss, I. Roxanis, J. Curnow, D. Beeson, N. Pantic, J. Newsom-Davis, A. Vincent, N. Willcox A pathogenic role for the thymoma in myasthenia gravis autosensitization of IL-4-producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes J Clin Invest 101 1998 2268
32. T. Horiki, H. Inoko, J. Moriuchi, Y. Ichikawa, S. Arimori Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan Autoimmunity 19 1994 49
33. P. Hjelmstrom, R. Giscombe, A.K. Lefvert, R. Pirskanen, I. Kockum, M. Landin-Olsson, C.B. Sanjeevi Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis Autoimmunity 22 1995 59
34. L.T. Tsuneto, C.M. Probst, M.H. Hutz, F.M. Salzano, L.A. Rodriguez-Delfin, M.A. Zago, K. Hill, A.M. Hurtado, A.K.C. Ribeiro-dod-Santos, M.L. Petzl-Erler HLA class II diversity in seven Amerindian populations clues about the origins of the Ache Tissue Antigens 62 2003 512
35. T. Yokoi, B. Mulac-Jericevic, J. Kurisaki, M.Z. Atassi T lymphocyte recognition of acetylcholine receptor Localization of the full T-cell recognition profile on the extracellular part of the α chain of Torpedo californica acetylcholine receptor Eur J Immunol 17 1987 1697
36. A.R. Pachner, F.S. Kantor, B. Mulac-Jericevic, M.Z. Atassi An immunodominant site of acetylcholine receptor in experimental myasthenia mapped with T-lymphocyte clones and synthetic peptides Immunol Lett 20 1989 199
37. M. Shenoy, M. Oshima, M.Z. Atassi, P. Christadoss Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region α146-162 of acetylcholine receptor Clin Immunol Immunopathol 66 1993 230