Scanning a DRB3*0101 (DR52a)-restricted epitope cross-presented by DR3: Overlapping natural and artificial determinants in the human acetylcholine receptor

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 4079-4087

  Nagvekar, Nita ^a   Corlett, Louise ^a   Jacobson, Leslie W ^a   Matsuo, Hidenori ^a,d   Chalkley, Robert ^b   Driscoll, Paul C ^b   Deshpande, Shrikant ^c   Spack, Edward G ^c   Willcox, Nicholas ^a,e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

^d Nagasaki Kawatana Medical Center   (Japan)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; EPITOPE; HLA DR ANTIGEN; PEPTIDE;

ALLELE; ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENETIC SUSCEPTIBILITY; IMMUNOTHERAPY; MYASTHENIA GRAVIS; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE; AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTATION; CELL LINE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; SYNTHESIS; TORPEDO;

ALLELES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGEN PRESENTATION; CELL LINE; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; HLA-DR ANTIGENS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MYASTHENIA GRAVIS; PEPTIDES; PROTEIN BINDING; RECEPTORS, CHOLINERGIC; TORPEDO;

EID: 0033106503     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Marsh, S. G., J. E. Moses, and J. G. Bodmer. 1992. HLA class II sequence polymorphism detectable by serology. In HLA 1991. K. Tsuji, M. Aizawa, and T. Sasazuki, eds. Oxford University Press, Oxford, U.K., p. 610.
2. Krieger, J. I., R. W. Karr, H. M. Grey, W. Y. Yu, D. O'Sullivan, L. Batovsky, Z. L. Zheng, S. M. Colon, F. C. A. Gaeta, J. Sidney, et al. 1991. Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition. J. Immunol. 148:2331.
3. Demotz, S., C. Barbey, G. Corradin, A. Amoroso, and A. Lanzavecchia. 1993. The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86. Eur. J. Immunol 23:425.
4. Newton-Nash, D. K., and D. D. Eckels. 1993. Differential effect of polymorphism at HLA-DR1 β-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides. J. Immunol. 150:1813.
5. O'Sullivan, D., J. Sidney, E. Appella, L. Walker, L. Phillips, S. M. Colon, C. Miles, R. W. Chesnut, and A. Sette. 1990. Characterization of the specificity of peptide binding to four DR haplotypes. J. Immunol. 145:1799.
6. Chicz, R. M., R. G. Urban, J. C. Gorga, D. A. A. Vignali, W. S. Lane, and J. L. Strominger. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27.
7. Rammensee, H-G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
8. Malcherek, G., V. Gnau, S. Stevanovic, H-G. Rammensee, G. Jung, and A. Melms. 1994 Analysis of allele-specific contact sites of natural HLA-DR17 ligands. J. Immunol. 153:1141.
9. Sidney, J., C. Oseroff, S. Southwood, M. Wall, G. Ishioka, F. Koning, and A. Sette. 1992. DRB1 *0301 molecules recognize a structural motif distinct from the one recognized by most DRβ alleles. 1992. J. Immunol. 149:2634.
10. Berdoz, J., J. Gorski, A-M. Termijtelen, J-M. Drayer, C. Irle, D. Schendel, and B. Mach. 1987. Constitutive and induced expression of the individual HLA-DR β and α chain loci in different cell types. J. Immunol. 139:1336.
11. Demotz, S., A. Lanzavecchia, U. Eisel, H. Niemann, C. Widmann, and G. Corradin. 1989. Delineation of several DR-restricted tetanus toxin T cell epitopes. J. Immunol. 142:394.
12. Bontrop, R. E., D. G. Elferink, N. Otting, M. Jonker, and R. R. P de Vries. 1990. Major histocompatibility complex class II-restricted antigen presentation across a species barrier: conservation of restriction determinants in evolution. J. Exp. Med. 172:53.
13. Wu, S., K. Maslanka, and J. Gorski. 1997 An integrin polymorphism that defines reactivity with alloantibodies generates an anchor for MHC class II peptide binding: a model for unidirectional alloimmune responses. J. Immunol. 158:3221.
14. Geluk, A., K. E. van Meijgaarden, S. Southwood, C. Oseroff. J. W. Drijfhout, R. R. P. de Vries. T. H. M. Ottenhoff, and A. Sette. 1994. HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs. J. Immunol. 152:5742.
15. Geluk, A., K. E. van Meijgaarden, A. A. M. Janson, J. W. Drijfhout. R. H. Meloen, R. P. De Vries, and T. H Ottenhoff. 1992. Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides. J. Immunol. 149:2864.
16. Geluk, A., X-T. Fu, K. E. van Meijgaarden, Y. Y. R. Jansen, R R. P. De Vries, R. W. Karr, and T. H. M. Ottenhoff. 1994. T cell receptor and peptide-contacting residues in the HLA-DR17(3) β1 chain. Eur. J. Immunol. 24:3241.
17. Willcox, N. 1993. Myasthenia gravis. Curr. Opin. Immunol. 5:910.
18. Hohlfeld, R., K. V. Toyka, K. Heinmger, H. Gross Wilde, and I. Kalies. 1984. Autoimmune human T lymphocytes specific for acetylcholine receptor. Nature 310:244.
19. Hawke, S., H. Matsuo, M. Nicolle, G. Malcherek, A. Melms, and N. Willcox. 1996. Autoimmune T cells in myasthenia gravis: heterogeneity and potential for specific immunotargeting. Immunol. Today 17:307.
20. Melms, A., G. Malcherek, U. Gern, H. Wietholter, C. A. Muller, R. Schoepfer, and J. Lindstrom. 1992. T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the α-subunit. Ann. Neurol. 31:311.
21. Oshima, M., T. Ashizawa, M. S. Pollack, and M. Z. Atassi. 1990. Autoimmune T cell recognition in myasthenia gravis on the extracellular part of the α subunit. Eur. J. Immunol. 20:2563.
22. Protti, M. P., A. Manfredi, R. M. Horton, M. Bellone, and B. M. Conti-Tronconi. 1993. Myasthenia gravis: recognition of a human autoantigen at the molecular level. Immunol. Today 14:363.
23. 86 HLA-DRβ dimorphism in autoantigen presentation to human T cells. Proc, Natl. Acad. Sci. USA 88:7343.
24. Nagvekai, N., A-M. Moody, P. Moss, I. Roxanis, J. Curnow, D. Beeson, N. Pantic, J. Newsom-Davis, A. Vincent, and N. Willcox. 1998. A pathogenetic róle for the thymoma in myasthenia gravis: autosensitization of IL4-producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes. J. Clin. Inverst. 101:2268.
25. Matsuo, H., A-P. Batocchi, S. Hawke, M. Nicolle, L. Jacobson, A. Vincent. J. Newsom-Davis, and N. Willcox. 1995. Peptide-selected T cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor. J. Immunol 155:3683.
26. Tompkins, S. M., P. A. Rota, J. C. Moore, and P. Jensen. 1993. A europium fluorimmunoassay for measuring binding of antigen to class II MHC glycoproteins. J. Immunol. Methods 163:209.
27. Stern, L. J., J. H. Brown, T. S. Jardetzky, J. C. Gorga, R. G. Urban, J. L. Stominger, and D. C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 eomplexed with an influenza virus peptide. Nature 368:215.
28. Ghosh, P., M. Amaya, E. Mellins, and D. C. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457.
29. Johnson, J. P., T. Meo, G. Riethmüller, D. J. SchEndel, and R. Wank. 1982. Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3. J. Exp. Med. 156:104.
30. Hawke, S., N. Willcox, G. Harcourt, A. Vincent, and J. Newsom-Davis. 1992. Stimulation of human T cells by sparse antigens captured on immunomagnetic particles. J. Immunol. Methods 155:41.
31. Savage, C. O. S., C. J. Brooks, G. C. Harcourt, J. K. Picard, W. King D. M. Sansom, and N. Willcox. 1995. Human vascular enuotheliaS cells process and present autoantigen to human T cell lines. Int. Immunol. 7:471.
32. + T cell clone from a myasthenia gravis patienl. J. Neuroimmunol. 46:57.
33. Shenoy, M., M. Oshima, M. Z. Atassi, and P. Christadoss. 1993. Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region α 146-162 of acetylcholine receptor. Clin. Immunol. Immunopathol. 66:230.
34. Reay, P. A., R. M. Kantor, and M. M. Davis. 1994. Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). J. Immunol. 152:3946.
35. Brett, S. J., D. McKean, J. York-Jolley, and J. A. Berzofsky. 1989. Antigen presentation to specific T cells by Ia molecules selectively altered by site-directed mutagenesis. Int. Immunol. 1:130.
36. Hill, M. E., D. Beeson, P. Moss, L. Jacobson, A. Bond, L. Corlett, A. Vincent, J. Newsom-Davis, and N. Willcox. 1999. An immunodominant epitope in the adult-specific acetylcholine receptor ∈ subunit. Ann. Neurol. 45:224.
37. Mellins, E., B. Arp, D. Singh, B. Carreno, L. Smith, A. H. Johnson, and D. Pious. 1990. Point mutations define positions in HLA-DR3 molecules that affect antigen presentation. Proc. Natl. Acad.Sci. USA 87:4785.
38. Wu, S., J. Gorski, D. D. Eckels, and D. K. Newton-Nash. 1996. T cell recognition of MHC class II-associated peptides is independent of peptide affinity for MHC and sodium dodecyl sulfate stability of the peptide/MHC complex. J. Immunol. 156:3815.
39. Viner, N. J. C. A. Nelson, B. Deck, and E. R. Unanue. 1996. Complexes generated by the binding of free peptides to class II MHC molecules are antigenieally diverse compared with those generated by intracellulur processing. J Immunol. 156:2365.
40. Grewal, L. S., K. D. Moudgil, and E. E. Sercarz 1995. Hindrance of binding to class II major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen. Proc. Natl. Acad. Sci. USA 92:1779.
41. Harcourt, G., A-P. Batocchi, S. Hawke, D. Beeson, N. Pantic, I., Jacobson, N. Willeox, A. Vincent, and J. Newsom-Davis. 1993. Detection of α-subunit isoforms in human muscle acetylcholine receptor by specific T cells from a myasthenia gravis patient. Proc. R. Soc. London Ser. B. 254:1.
42. Chen, W., N. J. Ede, D. C. Jackson, J. McCluskey, and A. W. Purcell. 1996. CTL recognition of an altered peptide associated with asparagine bond rearrangement. Implications for immunity and vaccine design. J. Immunol. 157:1000.
43. Molberg, Ø., S. N. Mcadam, R. Körner, H. Quarsten, C. Kristiansen, L. Madsen, I., Fugger, H. Scott, O. Norén, P. Roepstorff, et al. 1998. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat. Med. 4:713.
44. Elson, C. J., R. N. Barker, S. J. Thompson, and N., A. Williams. 1995. Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol. Today 16:71.
45. Hawke, S., H. Matsuo, M. Nicolle, P. Wordsworth, L. Corlett, E. Spack, S. Deshpande, P. Driscoll, and N. Willcox. 1999. Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: clues to arthritogenic peptide motifs. Arthritis Rheum. Vol 42 In press.
46. Matsuo, H., Hidenori, M., L. Corlett, S. Hawke, M. Nicolle, P. Driscoll, S. Deshpande, H. Spack, and N. Willcox. 1999. Distant interactions between dimorphisms in HLA-DR4 radically affect recognition of defined peptides by a specitic T cell clone. Int. Immunol. In press.