Polymorphic amino acid domains of the HLA-DQ molecule are associated with disease heterogeneity in myasthenia gravis

Journal of Neuroimmunology

Volumn 65, Issue 2, 1996, Pages 125-131

  Hjelmström, Peter ^a   Giscombe, Ricardo ^a   Lefvert, Ann Kari ^a   Pirskanen, Ritva ^b   Kockum, Ingrid ^a   Landin Olsson, Mona ^c   Sanjeevi, Carani B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b STOCKHOLM SÖDER HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Disease heterogeneity; HLA DQ; Myasthenia gravis; PCR SSO

Indexed keywords

HLA DQ ANTIGEN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MYASTHENIA GRAVIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SWEDEN; THYMOMA; THYMUS HYPERPLASIA;

EID: 0029888127     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-5728(96)00008-2     Document Type: Article

References (34)

1. Altmann, D.M. (1992) HLA-DQ associations with autoimmune disease. Autoimmunity 14, 17-83.
2. Bell, J., Smoot, S., Newby, C., Toyka, K., Rassenti, L., Smith, K., Hohlfeld, R., McDevitt, H., Steinman, L. (1986) HLA-DQ beta-chain polymorphism linked to myasthenia gravis. Lancet 1, 1058-1060.
3. Brown, J.H., Jardetsky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L., Wiley, D.C. (1993) Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364, 33-39.
4. Carlsson, B., Wallin, J., Pirskanen, R., Matell, G., Smith, C.I.E. (1990) Different HLA DR-DQ associations in subgroups of idiopathic myasthenia gravis. Immunogenetics 31, 285-290.
5. Christadoss, P., Lindstrom, J.M., Melvold, R.W., Talal, N. (1985) Mutation at I-Aβ chain prevents experimental autoimmune myasthenia gravis. Immunogenetics 31, 241-244.
6. Compston, D.A.S., Vincent, A., Newsom-Davis, J., Batchelor, J.R. (1980) Clinical, Pathological, HLA Antigen and Immunological Evidence for Disease Heterogeneity in Myasthenia Gravis. Brain 103, 579-601.
7. Conti-Tronconi, B.M., McLane, K.E., Raftery, M.A., Grando, S.A., Pia Protti, M. (1994) The nicotinic acetylcholine receptor: structure and autoimmune pathology. Crit. Rev. Biochem. Mol. Biol. 29, 69-123.
8. Drachman, D.B. (1994) Myasthenia gravis. N. Eng. J. Med. 330, 1797-1810.
9. Guardiola, J., Maffei, A. (1993) Control of MHC class II gene expression in autoimmune, infectious, and neoplastic diseases. Crit. Rev. Immunol. 13, 247-268.
10. Hjelmström, P., Giscombe, R., Lefvert, A.K., Pirskanen, R., Kockum, I., Landin-Olsson, M., Sanjeevi, C.B. (1996) Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis. Autoimmunity, in press.
11. Hohlfeld, R., Toyka, K.V., Tzartos, S.J., Carson, W., Conti-Tronconi, M. (1987) Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor α subunit. Proc. Natl. Acad Sci. USA 81, 5379-5383.
12. Hohlfeld, R., Wekerle, H. (1994) The role of the thymus in myasthenia gravis. Adv. Neuroimmunol. 4, 373-386.
13. Khalil, I., Berrih-Aknin, S., Lepage, V., Loste, M.-N., Gajdos, P., Hors, J., Charron, D., Degos, L. (1993) Trans -encoded DQαβ heterodimers confer susceptibility to myasthenia gravis disease. C.R. Acad, Sci, Paris 316, 652-660.
14. Kaul, R., Shenoy, M., Christadoss, P. (1994) The role of major histocompatibility complex genes in myasthenia gravis and experimental autoimmune myasthenia gravis pathogenesis. Adv. Neuroimmunol. 4, 387-402.
15. Lefvert, A. (1994) Human and experimental myasthenia gravis. In: A. Couthino, M. Kazatchine (Eds.) Autoimmunity: Physiology and Disease, Wiley-Liss Inc., New York, pp. 267-305.
16. Malcherek, G., Falk, K., Rötzschke, O., Rammensee, H.-G., Stefanovic, S., Gnau, V., Jung, G., Melms, A. (1993) Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis. Int. Immunol. 5, 1229-1237.
17. Nepom, G.T. (1995) Class II antigens and disease susceptibility. Annu. Rev. Med. 46, 17-25.
18. Olerup, O., Smith, C.I.E., Hammarström, L. (1990) Different amino acids at position 57 of the HLA DQβ chain associated with susceptibility and resistance to IgA deficiency. Nature 347, 289-290.
19. Oosterhuis, H.J.G.H. (1964) Studies in myasthenia gravis. J. Neurol. Sci. 1, 512.
20. Pirskanen, R., Tiilikainen, A., Hokkanen, E. (1972) Histocompatibility (HL-A) antigens associated with myasthenia gravis. Ann. Clin. Rev. 4, 304-306.
21. Rammensee, H.G. (1995) Chemistry of peptides associated with MHC class I and class II molecules. Curr. Opin. Immunol. 7, 85-96.
22. Sanjeevi, C.B., Seshiah, V., Möller, E., Olerup, O. (1992) Different genetic backgrounds for malnutrition-related diabetes and Type 1 (insulin-dependent) diabetes mellitus in South Indians. Diabetologia 35, 283-286.
23. Sanjeevi, C.B., Lybrand, T.P., DeWeese, C., Landin Olsson, M., Kockum, I., Dahlquist, G., Sundkvist, G., Stenger, D., Lernmark, Å. (1995) Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of insulin-dependent diabetes mellitus. Diabetes 1, 125-131.
24. Spurkland, A., Gilhus, N.E., Rønningen, K.S., Aarli, J.A., Vartdal, F. (1991) Myasthenia gravis patients with thymus hyperplasia and myasthenia gravis patients with thymoma display different HLA associations. Tissue Antigens 37, 90-93.
25. Stern, L.J., Brown, J.H., Jardetsky, T.S., Gorga, J.C., Urban, R.G., Strominger, J.L., Wiley, D.C. (1994) Crystal structure of the human class II MHC protein HLA-DR1complexed with an influenza virus peptide. Nature 368, 215-221.
26. Todd, J.A., Bell, J.I., McDevitt, H.O. (1987) HLA DQβ gene contributes to susceptibility from and resistance to insulin-dependent diabetes mellitus. Nature 329, 599-604.
27. Tournier-Lasserve, E., Bach, J.-F. (1993) The immunogenetics of myasthenia gravis, multiple sclerosis and their animal models. J. Neuroimmunol. 47, 103-114.
28. Verrek, F.A.W., van de Poel, A., Termijtelen, A., Amons, R., Drijfhout, J.-W., Koning, F. (1994) Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing. Eur. J. Immunol. 24, 375-379.
29. Vieira, M.L., Caillat-Zucman, S., Gajdos, V., Cohen-Kaminsky, S., Casteur, A., Bach, J.-F. (1993) Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J. Neuroimmunol. 47, 115-122.
30. Vincent, A. (1994) Aetiological factors in development of myasthenia gravis. Adv. Neuroimmunol. 4, 355-371.
31. Weyand, C.M., Goronzy, J.J. (1995) Inherited and noninherited risk factors in rheumatoid arthritis. Curr. Opin. Rheum. 7, 206-233.
32. Weyand, C.M., McCarthy, T.G., Goronzy, J.J. (1995) Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin. Invest. 95, 2120-2126.
33. Woolf, B. (1955) On estimating the relation between blood group and disease. Am. Hum. Genet. 19, 251-253.
34. Woolfrey, A.E., Nepom, G.T. (1995) Differential transcription elements direct expression of HLA-DQ genes. 74, 119-126.