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Volumn 8, Issue 5, 2006, Pages 555-560

Effect of acute ghrelin administration on glycaemia and insulin levels in obese patients

Author keywords

Ghrelin; Insulin; Obesity

Indexed keywords

GHRELIN; GLUCOSE; GLUCOSE OXIDASE; GROWTH HORMONE RELEASING FACTOR; INSULIN; PLACEBO;

EID: 33746925966     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2005.00551.x     Document Type: Article
Times cited : (14)

References (52)
  • 1
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998; 19: 717-797.
    • (1998) Endocr Rev , vol.19 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 2
    • 0034129850 scopus 로고    scopus 로고
    • Ghrelin: A step forward in the understanding of somatotroph cell function and growth regulation
    • Dieguez C, Casanueva FF. Ghrelin: A step forward in the understanding of somatotroph cell function and growth regulation. Eur J Endocrinol 2000; 142: 913-917.
    • (2000) Eur J Endocrinol , vol.142 , pp. 913-917
    • Dieguez, C.1    Casanueva, F.F.2
  • 3
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Data Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth hormone-releasing acylated peptide from stomach. Science 1999; 402: 656-658.
    • (1999) Science , vol.402 , pp. 656-658
    • Kojima, M.1    Hosoda, H.2    Data, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 4
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard HD, Feighner SD, Cully DF et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-976.
    • (1996) Science , vol.273 , pp. 974-976
    • Howard, H.D.1    Feighner, S.D.2    Cully, D.F.3
  • 5
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003; 37: 649-661.
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3
  • 6
    • 0242468428 scopus 로고    scopus 로고
    • Cellular distribution and regulation of ghrelin messenger ribonucleic acid in the rat pituitary gland
    • Caminos JE, Nogueiras R, Blanco M et al. Cellular distribution and regulation of ghrelin messenger ribonucleic acid in the rat pituitary gland. Endocrinology 2003; 144: 5089-5097.
    • (2003) Endocrinology , vol.144 , pp. 5089-5097
    • Caminos, J.E.1    Nogueiras, R.2    Blanco, M.3
  • 7
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004; 25: 426-457.
    • (2004) Endocr Rev , vol.25 , pp. 426-457
    • van der Lely, A.J.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 8
    • 0035083793 scopus 로고    scopus 로고
    • Biologic activities of growth hormone secretagogues in humans
    • Ghigo E, Arvat E, Giordano R et al. Biologic activities of growth hormone secretagogues in humans. Endocrine 2001; 14: 87-93.
    • (2001) Endocrine , vol.14 , pp. 87-93
    • Ghigo, E.1    Arvat, E.2    Giordano, R.3
  • 9
    • 0035890175 scopus 로고    scopus 로고
    • Inhibition of pancreatic protein secretion by ghrelin in the rat
    • Zhang W, Chen M, Chen X, Segura BJ, Mulholland MW. Inhibition of pancreatic protein secretion by ghrelin in the rat. J Physiol 2001; 537: 231-236.
    • (2001) J Physiol , vol.537 , pp. 231-236
    • Zhang, W.1    Chen, M.2    Chen, X.3    Segura, B.J.4    Mulholland, M.W.5
  • 10
    • 0037329049 scopus 로고    scopus 로고
    • Immuno-localization of ghrelin and its functional receptor, the type 1A growth hormone secretagogue receptor, in the cyclic human ovary
    • Gaytan F, Barreiro ML, Chopin LK et al. Immuno-localization of ghrelin and its functional receptor, the type 1A growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 2003; 88: 879-887.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 879-887
    • Gaytan, F.1    Barreiro, M.L.2    Chopin, L.K.3
  • 11
    • 0037066587 scopus 로고    scopus 로고
    • Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity
    • Muccioli G, Tschop M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity. Eur J Pharmacol 2002; 440: 235-254.
    • (2002) Eur J Pharmacol , vol.440 , pp. 235-254
    • Muccioli, G.1    Tschop, M.2    Papotti, M.3    Deghenghi, R.4    Heiman, M.5    Ghigo, E.6
  • 12
    • 17744374270 scopus 로고    scopus 로고
    • Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: Comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
    • Arvat E, Maccario M, Di Vito L et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: Comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 2001; 86: 1169-1174.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1169-1174
    • Arvat, E.1    Maccario, M.2    Di Vito, L.3
  • 13
    • 0036184544 scopus 로고    scopus 로고
    • Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats
    • Sibilia V, Pagani F, Guidobono F et al. Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats. Neuroendocrinology 2002; 75: 92-97.
    • (2002) Neuroendocrinology , vol.75 , pp. 92-97
    • Sibilia, V.1    Pagani, F.2    Guidobono, F.3
  • 14
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000; 407: 908-909.
    • (2000) Nature , vol.407 , pp. 908-909
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 15
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 16
    • 0036263016 scopus 로고    scopus 로고
    • Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding and adiposity
    • Shuto Y, Shibasaki T, Otagiri A et al. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding and adiposity. J Clin Invest 2002; 109: 1429-1436.
    • (2002) J Clin Invest , vol.109 , pp. 1429-1436
    • Shuto, Y.1    Shibasaki, T.2    Otagiri, A.3
  • 17
    • 12444333167 scopus 로고    scopus 로고
    • Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans
    • Broglio F, Benso A, Gottero C et al. Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans. J Endocrinol Invest 2003; 26: 192-196.
    • (2003) J Endocrinol Invest , vol.26 , pp. 192-196
    • Broglio, F.1    Benso, A.2    Gottero, C.3
  • 18
    • 0035320623 scopus 로고    scopus 로고
    • Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
    • Kojima M, Hosoda H, Matsuo H, Kangawa K. Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 2001; 12: 118-122.
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 118-122
    • Kojima, M.1    Hosoda, H.2    Matsuo, H.3    Kangawa, K.4
  • 19
    • 17744396454 scopus 로고    scopus 로고
    • Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    • Casoni P, Papotti M, Ghe C et al. Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab 2001; 86: 1738-1745.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1738-1745
    • Casoni, P.1    Papotti, M.2    Ghe, C.3
  • 20
    • 0142200403 scopus 로고    scopus 로고
    • Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghelin and des-Gln14-ghrelin
    • Bedendi I, Alloatti G, Marcantoni A et al. Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghelin and des-Gln14-ghrelin. Eur J Pharmacol 2003; 476: 87-95.
    • (2003) Eur J Pharmacol , vol.476 , pp. 87-95
    • Bedendi, I.1    Alloatti, G.2    Marcantoni, A.3
  • 21
    • 0035908954 scopus 로고    scopus 로고
    • Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    • Nagaya N, Uematsu M, Kojima M et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001; 104: 1430-1435.
    • (2001) Circulation , vol.104 , pp. 1430-1435
    • Nagaya, N.1    Uematsu, M.2    Kojima, M.3
  • 22
    • 0038297412 scopus 로고    scopus 로고
    • Ghrelin-leptin tango in body-weight regulation
    • Cummings DE, Foster KE. Ghrelin-leptin tango in body-weight regulation. Gastroenterology 2003; 124: 1532-1535.
    • (2003) Gastroenterology , vol.124 , pp. 1532-1535
    • Cummings, D.E.1    Foster, K.E.2
  • 23
    • 0036181821 scopus 로고    scopus 로고
    • Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion
    • Egido EM, Rodriguez-Gallardo J, Silvestre RA, Marco J. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol 2002; 146: 241-244.
    • (2002) Eur J Endocrinol , vol.146 , pp. 241-244
    • Egido, E.M.1    Rodriguez-Gallardo, J.2    Silvestre, R.A.3    Marco, J.4
  • 24
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Date Y, Nakazato M, Hashiguchi S et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002; 51: 124-129.
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3
  • 25
    • 0036141195 scopus 로고    scopus 로고
    • Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: Enteric distribution, ontogeny, influence of endocrine, and dietary manipulations
    • Lee HM, Wang G, Englander EW, Kojima M, Greeley GH Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002; 143: 185-190.
    • (2002) Endocrinology , vol.143 , pp. 185-190
    • Lee, H.M.1    Wang, G.2    Englander, E.W.3    Kojima, M.4    Greeley Jr., G.H.5
  • 26
    • 0036083399 scopus 로고    scopus 로고
    • Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats
    • Adeghate E, Ponery AS. Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. J Neuroendocrinol 2002; 14: 555-560.
    • (2002) J Neuroendocrinol , vol.14 , pp. 555-560
    • Adeghate, E.1    Ponery, A.S.2
  • 27
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • Broglio F, Arvat E, Benso A et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 2001; 86: 5083-5086.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3
  • 28
    • 0038699022 scopus 로고    scopus 로고
    • The endocrine response to ghrelin as a function of gender in human young and elderly subjects
    • Broglio F, Benso A, Castiglioni C et al. The endocrine response to ghrelin as a function of gender in human young and elderly subjects. J Clin Endocrinol Metab 2003; 88: 1537-1542.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1537-1542
    • Broglio, F.1    Benso, A.2    Castiglioni, C.3
  • 30
    • 2342465508 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects
    • Akamizu T, Takaya K, Irako T et al. Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur J Endocrinol 2004; 150: 447-455.
    • (2004) Eur J Endocrinol , vol.150 , pp. 447-455
    • Akamizu, T.1    Takaya, K.2    Irako, T.3
  • 31
    • 0035216623 scopus 로고    scopus 로고
    • Ghrelin enhances appetite and increases food intake in humans
    • Wren AM, Seal LJ, Cohen MA et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86: 5992-5998.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5992-5998
    • Wren, A.M.1    Seal, L.J.2    Cohen, M.A.3
  • 32
    • 18244391222 scopus 로고    scopus 로고
    • Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion
    • Shiiya T, Nakazato M, Mizuta M et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002; 87: 240-244.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 240-244
    • Shiiya, T.1    Nakazato, M.2    Mizuta, M.3
  • 33
    • 0037240916 scopus 로고    scopus 로고
    • Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome
    • Haqq AM, Farooqi IS, O'Rahilly S et al. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. J Clin Endocrinol Metab 2003; 88: 174-178.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 174-178
    • Haqq, A.M.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 35
    • 0000067107 scopus 로고    scopus 로고
    • Genetis and pathophysiology of human obesity
    • Cummings DE, Schwartz MW. Genetis and pathophysiology of human obesity. Annu Rev Med 2003; 4: 453-471.
    • (2003) Annu Rev Med , vol.4 , pp. 453-471
    • Cummings, D.E.1    Schwartz, M.W.2
  • 38
    • 0036347936 scopus 로고    scopus 로고
    • Insulin regulates plasma ghrelin concentration
    • Saad MF, Bernaba B, Hwu C et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 2002; 87: 397-400.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 397-400
    • Saad, M.F.1    Bernaba, B.2    Hwu, C.3
  • 40
    • 0036789176 scopus 로고    scopus 로고
    • Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia
    • Lucidi P, Murdolo G, Di Loreto G et al. Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes 2002; 51: 2911-2914.
    • (2002) Diabetes , vol.51 , pp. 2911-2914
    • Lucidi, P.1    Murdolo, G.2    Di Loreto, G.3
  • 41
    • 0036959760 scopus 로고    scopus 로고
    • Expression of ghrelin and the GH secretagogue receptor by the pancreatic islet cells and related endocrine tumors
    • Volante M, Allia E, Gugliotta P et al. Expression of ghrelin and the GH secretagogue receptor by the pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002; 87: 1300-1308.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1300-1308
    • Volante, M.1    Allia, E.2    Gugliotta, P.3
  • 42
    • 0037098974 scopus 로고    scopus 로고
    • The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas
    • Wierup N, Svensson H, Sundler F. The ghrelin cell: A novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002; 107: 63-69.
    • (2002) Regul Pept , vol.107 , pp. 63-69
    • Wierup, N.1    Svensson, H.2    Sundler, F.3
  • 43
    • 0141453037 scopus 로고    scopus 로고
    • Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans
    • Broglio F, Gottero C, Benso A et al. Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans. J Clin Endocrinol Metab 2003; 88: 4268-4272.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4268-4272
    • Broglio, F.1    Gottero, C.2    Benso, A.3
  • 44
    • 10744223439 scopus 로고    scopus 로고
    • Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity
    • Tassone F, Broglio F, Destefanis S et al. Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity. J Clin Endocrinol Metab 2003; 88: 5478-5483.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5478-5483
    • Tassone, F.1    Broglio, F.2    Destefanis, S.3
  • 45
    • 6344291317 scopus 로고    scopus 로고
    • Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacetylated ghrelin strongly improves insulin sensitivity
    • Gauna C, Meyler FM, Janssen J et al. Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacetylated ghrelin strongly improves insulin sensitivity. J Clin Endocrinol Metab 2004; 89: 5035-5042.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5035-5042
    • Gauna, C.1    Meyler, F.M.2    Janssen, J.3
  • 46
    • 0037372044 scopus 로고    scopus 로고
    • Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    • Reimer MK, Pacini G, Ahren B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 2003; 144: 916-921.
    • (2003) Endocrinology , vol.144 , pp. 916-921
    • Reimer, M.K.1    Pacini, G.2    Ahren, B.3
  • 48
    • 0024595628 scopus 로고
    • Cholinergic receptor activation by pyridostigmine restores GH responsiveness to GH-releasing hormone administration in obese subjects
    • Cordido F, Casanueva FF, Dieguez C. Cholinergic receptor activation by pyridostigmine restores GH responsiveness to GH-releasing hormone administration in obese subjects. J Clin Endocrinol Metab 1989; 68: 290-293.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 290-293
    • Cordido, F.1    Casanueva, F.F.2    Dieguez, C.3
  • 49
    • 0033780069 scopus 로고    scopus 로고
    • Development of obesity in transgenic rats with low circulating growth hormone levels: Involvement of leptin resistance
    • Furuhata Y, Kagaya R, Hirabayashi K et al. Development of obesity in transgenic rats with low circulating growth hormone levels: Involvement of leptin resistance. Eur J Endocrinol 2000; 143: 535-541.
    • (2000) Eur J Endocrinol , vol.143 , pp. 535-541
    • Furuhata, Y.1    Kagaya, R.2    Hirabayashi, K.3
  • 50
    • 0032462257 scopus 로고    scopus 로고
    • Effect of acute pharmacological reduction of plasma free fatty acids on GHRH-induced GH secretion in obese adults with and without hypopituitarism
    • Cordido F, Fernandez T, Martinez T, PeinóR, Dieguez C, Casanueva F. Effect of acute pharmacological reduction of plasma free fatty acids on GHRH-induced GH secretion in obese adults with and without hypopituitarism. J Clin Endocrinol Metab 1998; 83: 4350-4354.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 4350-4354
    • Cordido, F.1    Fernandez, T.2    Martinez, T.3    Peinó, R.4    Dieguez, C.5    Casanueva, F.6
  • 51
    • 0029039609 scopus 로고
    • Effect of the combined administration of Growth Hormone (GH)-releasing hormone, GH-releasing peptide-6 and pyridostigmine in normal and obese subjects
    • Cordido F, Peñalva A, Peino R, Casanueva F, Dieguez C. Effect of the combined administration of Growth Hormone (GH)-releasing hormone, GH-releasing peptide-6 and pyridostigmine in normal and obese subjects. Metabolism 1995; 44: 745-748.
    • (1995) Metabolism , vol.44 , pp. 745-748
    • Cordido, F.1    Peñalva, A.2    Peino, R.3    Casanueva, F.4    Dieguez, C.5
  • 52
    • 4143057995 scopus 로고    scopus 로고
    • Marked GH secretion after ghrelin administration alone or combined with growth hormone-releasing hormone (GHRH) in obese patients
    • Alvarez P, Isidro L, Garcia-Buela J et al. Marked GH secretion after ghrelin administration alone or combined with growth hormone-releasing hormone (GHRH) in obese patients. Clin Endocrinol 2004; 61: 250-255.
    • (2004) Clin Endocrinol , vol.61 , pp. 250-255
    • Alvarez, P.1    Isidro, L.2    Garcia-Buela, J.3


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