Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: Relative disposition of chloral hydrate to trichloroacetate and trichloroethanol

Environmental Health Perspectives

Volumn 114, Issue 8, 2006, Pages 1237-1242

  Bronley DeLancey, Apryl ^a   McMillan, David C ^b   McMillan, JoEllyn M ^b   Jollow, David J ^b   Mohr, Lawrence C ^a,b   Hoel, David G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Alcohol dehydrogenase; Aldehyde dehydrogenase; Chloral hydrate; Genetic variability; Human hepatocytes; Metabolism; Risk assessment; Trichloroacetate; Trichloroethylene

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CHLORAL HYDRATE; TRICHLOROETHANOL; TRICHLOROETHYLENE;

ADULT; AGED; ARTICLE; CANCER RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYOPRESERVATION; ENZYME ASSAY; FEASIBILITY STUDY; FEMALE; GENOTYPE; HUMAN; HUMAN CELL; INFANT; LIVER CELL; LIVER METABOLISM; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; SAMPLE SIZE;

ADULT; AGED; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ANIMALS; CHLORAL HYDRATE; CRYOPRESERVATION; ETHYLENE CHLOROHYDRIN; FEMALE; GENOTYPE; HEPATOCYTES; HUMANS; KINETICS; MALE; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SOLVENTS; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

EID: 33746895500     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9047     Document Type: Article

References (28)

1. Abbas RR, Seckel CS, Kidney JK, Fisher JW. 1996. Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice. Drug Metab Dispos 24:1340-1346.
2. Aldridge JE, Gibbons JA, Flaherty MM, Kreider ML, Romano JA, Levin ED. 2003. Heterogeneity of toxicant response: sources of human variability. Toxicol Sci 76:3-20.
3. Bull RJ. 2000. Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate. Environ Health Perspect 108:241-259.
4. Bull RJ, Omer GA, Chang RS, Stillwell L, Stauber AJ, Sasser LB, et al. 2002. Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol Appl Pharmacol 187:55-65.
5. Burrell JC, Li TK, Bosron WF. 1989. Purification and steady-state kinetic characterization of human liver beta 3 beta 3 alcohol dehydrogenase. Biochemistry 28:6810-6815.
6. Clewell HJ, Andersen ME. 2004. Applying mode-of-action and pharmacokinetic considerations in contemporary cancer risk assessments: an example with trichloroethylene. Crit Rev Toxicol 34:385-445.
7. Dalziel K, Dickinson FM. 1966. The kinetics and mechanism of liver alcohol dehydrogenase with primary and secondary alcohols as substrates. Biochem J 100:34-46.
8. Davidson IW, Beliles RP. 1991. Consideration of the target organ toxicity of trichloroethylone in terms of metabolite toxicity and pharmacokinetics. Drug Metab Rev 23:493-599.
9. Ehrig T, Bosron WF, Li TK. 1990. Alcohol and aldehyde dehydrogenase. Alcohol Alcohol 25:105-116.
10. Fay RM, Mumtaz MM. 1996. Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database. Food Chem Toxicol 34:1163-1165.
11. Fisher JW. 2000. Physiologically-based pharmacokinetic models for trichloroethylene and its oxidative metabolites. Environ Health Perspect 108:265-273.
12. Gentry PR, Hack CE, Haber L, Maier A, Clowell HJ. 2002. An approach for the quantitative consideration of genetic polymorphism date in chemical risk assessment: examples with warfarin and parathion. Toxical Sci 70:120-139.
13. Herren-Freund SL, Periere MA, Khoury MD, Olson G. 1987. The carcinogenicity of trichloroethylone and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol Appl Pharmacol 90:183-189.
14. Institute of Laboratory Animal Resources. 1996. Guide for the Care and Use of Laboratory Animals. 7th ed. Washington, DC:Nationel Academy Press.
15. Lewandowski TA, Rhomber L 2005. A proposed methodology for selecting a trichloroethylene inhalation unit risk value for use in risk assessment Regul Toxicol Pharmacol 41:39-54.
16. Li TK, Yin SJ, Crabb DW, O'Connor S, Ramchandani VA. 2001. Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 25:136-144.
17. Lipscomb JC, Garrett CM, Snawder JE. 1997. Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans. Toxicol Appl Pharmacol 142:311-318.
18. Lipscomb JC, Mahle D, Brashear WT, Garrett CM. 1996. A species comparison of chloral hydrate metabolism in blood and liver. Biochem Biophys Res Commun 14:340-350.
19. Mulligan CJ, Robin RW, Osier MV, Sambuughin N, Goldfarb LG, Kitdas RA, et al. 2003. Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. Hum Genet 113:325-336.
20. Muralidhara S, Bruckner JV. 1999. Simple method for rapid measurement of trichloroethylene and its major metabolites in biological samples. J Chromatogr B 732:145-153.
21. Nakajima T, Wang RS, Elovaara E, Park SS, Gelboin HV, Vainio H. 1992. A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem Pharmacol 43:251-257.
22. Nakamura K, Iwahashi K, Matsuo Y, Suwaki H, Ichikawa Y. 1993. Improved methods for genotype determination at the ALDH2 locus using PCR by introducing the MBOII recognition site or conducting secondary PCR. Biochem Mol Biol Int 31:439-445.
23. Osier M Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, et al. 1999. Linkage disequilibrium at the ADH2 and ADH31oci and risk of alcoholism. Am J Hum Genet 64:1147-1157.
24. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, et al. 1985. Measurement of protein using bicinchoninic acid [published erratum. Anal Biochem 163(l):2791]. Anal Biochern 150:76-85.
25. Theorell H, Chance B. 1951. Studies on liver alcohol dehydrogenase. 2 The kinetics of the compound of horse liver alcohol dehydrogonase and reduced diphosphopyridine nucleotide. Acta Chem Scand 5:1127-1144.
26. Wartenburg D, Reyner D, Scott C. 2000. Trichloroethylene and cancer: epidemiologic evidence. Environ Health Perspect 108:161-176.
27. Xu YL, Carr LG, Bosron WF, Li TK, Edenburg HJ. 1988. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209-214.
28. Yin SJ, Bosron WF, Magnes LJ, Li TK 1984. Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 "oriental" isoenzymes. Biochemistry 23:5847-5853.