-
1
-
-
73849173431
-
A study of the hypnotic activity of chloral hydrate
-
F. J. Mackey and J. R. Cooper: A study of the hypnotic activity of chloral hydrate. J. Pharmacol. Exp. Ther. 135, 271-274 (1962).
-
(1962)
J. Pharmacol. Exp. Ther.
, vol.135
, pp. 271-274
-
-
Mackey, F.J.1
Cooper, J.R.2
-
3
-
-
0018604993
-
Clinical effects of chloral hydrate in hospitalized medical patients
-
R. R. Miller and D. J. Greenblatt: Clinical effects of chloral hydrate in hospitalized medical patients. J. Pharmacol. 19, 669-674 (1979).
-
(1979)
J. Pharmacol.
, vol.19
, pp. 669-674
-
-
Miller, R.R.1
Greenblatt, D.J.2
-
4
-
-
0025146931
-
Chloral hydrate warning
-
M. T. Smith: Chloral hydrate warning. Science October 359 (1985).
-
(1985)
Science
, vol.OCTOBER
, pp. 359
-
-
Smith, M.T.1
-
5
-
-
8044249781
-
Organic solutes
-
chap. 6, National Academy of Sciences, Washington, D.C.
-
NAS: Organic solutes. In "Drinking Water and Health," chap. 6, pp. 707-709. National Academy of Sciences, Washington, D.C., 1977.
-
(1977)
Drinking Water and Health
, pp. 707-709
-
-
-
6
-
-
8044231058
-
-
Office of Toxic Substance, U.S. Environmental Protection Agency, Washington, D.C., draft, March 31
-
EPA: "Chemical Hazard Information Profile. Trichloroacetaldehyde." Office of Toxic Substance, U.S. Environmental Protection Agency, Washington, D.C., draft, March 31, 1982.
-
(1982)
Chemical Hazard Information Profile. Trichloroacetaldehyde
-
-
-
9
-
-
8044249780
-
-
CAS No. 79-01-6, NCI-CG-2. NCI, Washington, D.C.
-
National Cancer Institute: "Carcinogenisis Bioassay of Trichloroethylene." CAS No. 79-01-6, NCI-CG-2. NCI, Washington, D.C., 1983.
-
(1983)
Carcinogenisis Bioassay of Trichloroethylene
-
-
-
11
-
-
0010648204
-
-
ACI, August, Marshall, Osborne-Mendel, NTP 273, Research Triangle Park, NC: NIH Publication No. 88-2529
-
National Toxicology Program: "Toxicology and Carcinogenesis Studies of Trichloroethylene in 4 Strains of Rats." ACI, August, Marshall, Osborne-Mendel, NTP 273, Research Triangle Park, NC: NIH Publication No. 88-2529, 1988.
-
(1988)
Toxicology and Carcinogenesis Studies of Trichloroethylene in 4 Strains of Rats
-
-
-
12
-
-
0023690866
-
Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice
-
C. Maltoni, G. Lefemine, G. Cotti, and G. Perino: Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice. Ann. N. Y. Acad Sci. 534, 316 (1988).
-
(1988)
Ann. N. Y. Acad Sci.
, vol.534
, pp. 316
-
-
Maltoni, C.1
Lefemine, G.2
Cotti, G.3
Perino, G.4
-
13
-
-
0023510171
-
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver
-
S. L. Herren-Freund, M. A. Pereira, M. D. Khoury, and G. Olson: The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90, 183-189 (1987).
-
(1987)
Toxicol. Appl. Pharmacol.
, vol.90
, pp. 183-189
-
-
Herren-Freund, S.L.1
Pereira, M.A.2
Khoury, M.D.3
Olson, G.4
-
14
-
-
0024394728
-
Genetic toxicology of 1,1,2-trichloroethylene
-
R. Crebelli and A. Carere: Genetic toxicology of 1,1,2-trichloroethylene. Mutat. Res. 221, 11-37 (1989).
-
(1989)
Mutat. Res.
, vol.221
, pp. 11-37
-
-
Crebelli, R.1
Carere, A.2
-
15
-
-
77957179532
-
Hepatocarcinogenicity of chloral hydrate, 2-chloroacetylaldehyde, and dichloracetic acid in the male B6C3F1 mouse
-
F. B. Daniel, A. B. Stober, J. A. Olson, and G. R. N. P. Pages: Hepatocarcinogenicity of chloral hydrate, 2-chloroacetylaldehyde, and dichloracetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 19, 159-168 (1992).
-
(1992)
Fundam. Appl. Toxicol.
, vol.19
, pp. 159-168
-
-
Daniel, F.B.1
Stober, A.B.2
Olson, J.A.3
Pages, G.R.N.P.4
-
16
-
-
0021923010
-
Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose-effect study
-
J. A. Buben and E. J. O'Flaherty: Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. Toxicol. Appl. Pharmacol. 78, 105-122 (1985).
-
(1985)
Toxicol. Appl. Pharmacol.
, vol.78
, pp. 105-122
-
-
Buben, J.A.1
O'Flaherty, E.J.2
-
17
-
-
0030067740
-
Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism
-
W. C. Ni, T. Y. Wong, R. V. Lloyd, T. M. Heinze, S. Shelton, D. Casciano, F. F. Kadlubar, and Peter P. Fu: Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism. Drug Metab. Dispos. 24, 81-90 (1996).
-
(1996)
Drug Metab. Dispos.
, vol.24
, pp. 81-90
-
-
Ni, W.C.1
Wong, T.Y.2
Lloyd, R.V.3
Heinze, T.M.4
Shelton, S.5
Casciano, D.6
Kadlubar, F.F.7
Fu, P.P.8
-
18
-
-
0343558419
-
Metabolic transformations of trichloroethylene
-
T. C. Butler: Metabolic transformations of trichloroethylene. J. Pharmacol. Exp. Ther. 97, 84-92 (1949).
-
(1949)
J. Pharmacol. Exp. Ther.
, vol.97
, pp. 84-92
-
-
Butler, T.C.1
-
19
-
-
0021263456
-
Novel metabolism of trichloroethylene through dechlorination reactions in rats, mice and humans
-
W. Dekant, M. Metzler, and D. Henschler: Novel metabolism of trichloroethylene through dechlorination reactions in rats, mice and humans. Biochem. Pharmacol. 33, 2021-2027 (1984).
-
(1984)
Biochem. Pharmacol.
, vol.33
, pp. 2021-2027
-
-
Dekant, W.1
Metzler, M.2
Henschler, D.3
-
20
-
-
0026346879
-
Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics
-
I. W. F. Davidson and R. P. Beliles: Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. Drug Metab. Rev. 23, 493-599 (1991).
-
(1991)
Drug Metab. Rev.
, vol.23
, pp. 493-599
-
-
Davidson, I.W.F.1
Beliles, R.P.2
-
21
-
-
0003980471
-
-
EPA/600/8-82/006F, Final Report. U.S. EPA, Washington, D.C.
-
U.S. Environmental Protection Agency: "Health Assessment Document for Trichloroethylene," EPA/600/8-82/006F, Final Report. U.S. EPA, Washington, D.C., 1985.
-
(1985)
Health Assessment Document for Trichloroethylene
-
-
-
22
-
-
0002799804
-
Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol
-
E. K. Marshall, Jr. and A. H. Owens, Jr.: Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol. Bull. Johns Hopkins Hosp. 95, 1-18 (1954).
-
(1954)
Bull. Johns Hopkins Hosp.
, vol.95
, pp. 1-18
-
-
Marshall Jr., E.K.1
Owens Jr., A.H.2
-
23
-
-
0014831156
-
The kinetics of chloral hydrate metabolism in mice and the effect thereon of ethanol
-
B. E. Cabana and P. K. Gessner: The kinetics of chloral hydrate metabolism in mice and the effect thereon of ethanol. J. Pharmacol. Exp. Ther. 174, 260-275 (1970).
-
(1970)
J. Pharmacol. Exp. Ther.
, vol.174
, pp. 260-275
-
-
Cabana, B.E.1
Gessner, P.K.2
-
24
-
-
0018245706
-
Comparative metabolism of chloral hydrate and trichlofos
-
E. M. Sellers, M. L. Sellers, and J. K. Weser: Comparative metabolism of chloral hydrate and trichlofos. J. Clin. Pharmacol. 18, 457-461 (1978).
-
(1978)
J. Clin. Pharmacol.
, vol.18
, pp. 457-461
-
-
Sellers, E.M.1
Sellers, M.L.2
Weser, J.K.3
-
25
-
-
0025375917
-
Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration
-
D. K. J. Gorecki, K. W. Hindmarsh, C. A. Hall, and D. J. Mayers: Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration. J. Chromatogr. 528, 333-341 (1990).
-
(1990)
J. Chromatogr.
, vol.528
, pp. 333-341
-
-
Gorecki, D.K.J.1
Hindmarsh, K.W.2
Hall, C.A.3
Mayers, D.J.4
-
26
-
-
0025770611
-
Chloral hydrate disposition following single-dose administration to critically ill neonates and children
-
D. J. Mayers, K. W. Hindmarsh, and K. Sankaran: Chloral hydrate disposition following single-dose administration to critically ill neonates and children. Dev. Pharmacol. Ther. 16, 71-77 (1991).
-
(1991)
Dev. Pharmacol. Ther.
, vol.16
, pp. 71-77
-
-
Mayers, D.J.1
Hindmarsh, K.W.2
Sankaran, K.3
-
27
-
-
0029952001
-
Factors influencing the conversion of trichloroacetic acid to dichloroacetic acid in biological matrices
-
M. M. Ketcha, D. A. Warren, C. T. Bishop, and W. T. Brashear: Factors influencing the conversion of trichloroacetic acid to dichloroacetic acid in biological matrices. J. Analyt. Toxicol. 20, 236-241 (1996).
-
(1996)
J. Analyt. Toxicol.
, vol.20
, pp. 236-241
-
-
Ketcha, M.M.1
Warren, D.A.2
Bishop, C.T.3
Brashear, W.T.4
-
28
-
-
0019274427
-
The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption lime
-
S. Riegelman and P. Collier: The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption lime. J. Pharmacokinet. Biopharm. 8, 509-534 (1980).
-
(1980)
J. Pharmacokinet. Biopharm.
, vol.8
, pp. 509-534
-
-
Riegelman, S.1
Collier, P.2
-
30
-
-
0018606615
-
Noncompartmental determination of the steady state volume of distribution
-
L. Z. Benet and R. L. Galeazzi: Noncompartmental determination of the steady state volume of distribution. J. Pharm. Sci. 68, 1017-1074 (1979).
-
(1979)
J. Pharm. Sci.
, vol.68
, pp. 1017-1074
-
-
Benet, L.Z.1
Galeazzi, R.L.2
-
31
-
-
0000300591
-
Reduction and oxidation of chloral hydrate by isolated tissues in vitro
-
T. C. Butler: Reduction and oxidation of chloral hydrate by isolated tissues in vitro. J. Pharmacol. Exp. Ther. 95, 360-372 (1949).
-
(1949)
J. Pharmacol. Exp. Ther.
, vol.95
, pp. 360-372
-
-
Butler, T.C.1
-
32
-
-
0020615440
-
Inhibition of alcohol dehydrogenase by chloral hydrate and trichloroethanol: Possible role in the chloral hydrate-ethanol interaction
-
M. Sharkawi, G. D. S. Blanquat, and B. Elfassy: Inhibition of alcohol dehydrogenase by chloral hydrate and trichloroethanol: possible role in the chloral hydrate-ethanol interaction. Toxicol. Lett. 17, 321-328.
-
Toxicol. Lett.
, vol.17
, pp. 321-328
-
-
Sharkawi, M.1
Blanquat, G.D.S.2
Elfassy, B.3
-
33
-
-
0015256481
-
Interaction of chloral hydrate and ethanol in man. I. Metabolism
-
E. M. Sellers, M. Lang, J. Koch-Weser, E. LeBlanc, and H. Kalant: Interaction of chloral hydrate and ethanol in man. I. Metabolism. Clin. Pharmacol. Ther. 13, 37-49 (1972).
-
(1972)
Clin. Pharmacol. Ther.
, vol.13
, pp. 37-49
-
-
Sellers, E.M.1
Lang, M.2
Koch-Weser, J.3
LeBlanc, E.4
Kalant, H.5
-
34
-
-
0023187113
-
Extrahepatic metabolism of chloral hydrate, trichloroethanol and trichloroacetic acid in dogs
-
T. Hobara, H. Kobayashi, T. Kawamoto, S. Iwamoto, and T. Sakai: Extrahepatic metabolism of chloral hydrate, trichloroethanol and trichloroacetic acid in dogs. Pharmacol. Toxicol. 61, 58-62 (1987).
-
(1987)
Pharmacol. Toxicol.
, vol.61
, pp. 58-62
-
-
Hobara, T.1
Kobayashi, H.2
Kawamoto, T.3
Iwamoto, S.4
Sakai, T.5
-
35
-
-
0003414262
-
-
Merck & Co., Inc., Rahway, NJ
-
S. Budavari, M. J. O'Neil, A. Smith, and P. E. Heckelman: "The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals," 11th ed. Merck & Co., Inc., Rahway, NJ, 1989.
-
(1989)
"The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals," 11th Ed.
-
-
Budavari, S.1
O'Neil, M.J.2
Smith, A.3
Heckelman, P.E.4
-
36
-
-
0027385555
-
Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice
-
M. V. Templin, J. C. Parker, and R. J. Bull: Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice. Toxicol. Appl. Pharmacol. 123, 1-8 (1993).
-
(1993)
Toxicol. Appl. Pharmacol.
, vol.123
, pp. 1-8
-
-
Templin, M.V.1
Parker, J.C.2
Bull, R.J.3
-
37
-
-
0023180184
-
The metabolite ratio as a function of chloral hydrate dose and intracellular redox state in the perfused rat liver
-
T. Kawamoto, T. Hobara, H. Kobayashi, S. Iwamoto, T. Sakai, T. Takano, and Y. Miyazaki: The metabolite ratio as a function of chloral hydrate dose and intracellular redox state in the perfused rat liver. Pharmacol. Toxicol. 60, 325-329 (1987).
-
(1987)
Pharmacol. Toxicol.
, vol.60
, pp. 325-329
-
-
Kawamoto, T.1
Hobara, T.2
Kobayashi, H.3
Iwamoto, S.4
Sakai, T.5
Takano, T.6
Miyazaki, Y.7
-
38
-
-
0010531349
-
Comparison of the in vitro metabolism of trichoroethylene in three species: Rat, mouse, and human
-
J. C. Lipscomb, C. M. Garrett, and D. A. Mahle: Comparison of the in vitro metabolism of trichoroethylene in three species: rat, mouse, and human (Abstract). Toxicologist, 30, 318 (1996).
-
(1996)
Toxicologist
, vol.30
, pp. 318
-
-
Lipscomb, J.C.1
Garrett, C.M.2
Mahle, D.A.3
-
39
-
-
0015957870
-
Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysis
-
D. D. Breimer, H. C. J. Ketelaars, and J. M. Van Rossum: Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysis. J. Chromatogr. 88, 55-63 (1974).
-
(1974)
J. Chromatogr.
, vol.88
, pp. 55-63
-
-
Breimer, D.D.1
Ketelaars, H.C.J.2
Van Rossum, J.M.3
|