Do MSI-L sporadic colorectal tumors develop through "mild mutator pathway"?

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 29, Issue 4, 2006, Pages 364-370

  Oliart, Soledad ^a   Martínez Santos, Cristina ^b   Moreno Azcoita, Mariano ^b   Cerquella, Carlos ^a   Nejda, Nargisse ^c   Daimiel, Lydia ^c   Iglesias, Daniel ^c   Fernández Peralta, Antonia M ^c   González Aguilera, Juan J ^c  

^a HOSPITAL CENTRAL DE LA CRUZ ROJA   (Spain)

^b HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Colorectal cancer; Microsatellite instability; Mild mutator pathway; Mutator pathway; Suppressor pathway

Indexed keywords

DNA; K RAS PROTEIN; PROTEIN P53; KRAS2 PROTEIN, HUMAN; MICROSATELLITE DNA; MSH2 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN MSH2;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER STAGING; CANCER SURGERY; COLORECTAL CANCER; CONTROLLED STUDY; DENSITOMETRY; FEMALE; GENE MUTATION; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; ONCOGENE K RAS; PHENOTYPE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SUPPRESSOR GENE; SURVIVAL TIME; COLORECTAL TUMOR; GENETICS; MIDDLE AGED; MORTALITY; MUTATION; PATHOLOGY; SURVIVAL;

AGED; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; PHENOTYPE; PROTO-ONCOGENE PROTEINS; SURVIVAL ANALYSIS;

EID: 33746861654     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/01.coc.0000221428.35366.cb     Document Type: Article

References (46)

1. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87:159-170.
2. Jass JR, Biden KG, Cummings MC, et al. Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. J Clin Pathol. 1999;52:455-460.
3. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal tumour development. N Engl J Med. 1988;319:525-532.
4. Aaltonen LA, Peltomäki P, Leach FS, et al. Clues to pathogenesis of familial colorectal cancer. Science. 1993;260:812-816.
5. Ionov Y, Peinado MA, Malkhosyan S, et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature. 1993;363:558-561.
6. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science. 1993;260:816-819.
7. Goel A, Arnold CN, Niedzwiecki D, et al. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res. 2003;63:1608-1614.
8. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248-5257.
9. Markowitz S. DNA repair defects inactivate tumour suppressor genes and induce hereditary and sporadic colon cancers. J Clin Oncol. 2000;18(suppl):75S- 80S.
10. Bubb VJ, Curtis LJ, Cunningham C, et al. Microsatellite instability and the role of hMSH2 in sporadic colorectal cancer. Oncogene. 1996;12:2641-2649.
11. Lukish JR, Muro K, Denobile J, et al. Prognostic significance of DNA replication errors in young patients with colorectal cancer. Ann Surg. 1998;227:51-56.
12. Cawkwell L, Gray S, Murgatroyd H, et al. Choice of management strategy for colorectal cancer based on a diagnostic inmunohistochemical test for defective mismatch repair. Gut. 1999;45:409-415.
13. Wright CM, Dent OF, Barker M, et al. Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg. 2000;87:1197-1202.
14. Messerini L, Ciantelli M, Baglioni S, et al. Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers. Hum Pathol. 1999;30:629-634.
15. Salahshor S, Kressner U, Fischer H, et al. Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer. 1999;81:190-193.
16. Curran B, Lenehan K, Mulcahy H, et al. Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3, N0, M0) colorectal cancer. Gut. 2000;46:200-204.
17. Ward R, Meagher A, Tomlinson I, et al. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut. 2001;48:821-829.
18. Whitehall VLJ, Wynter CVA, Walsh MD, et al. Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. Cancer Res. 2002;62:6011-6014.
19. Iino H, Jass JR, Simms LA, et al. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol. 1999;52:5-9.
20. Biden KG, Simms LA, Cummings M, et al. Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability. Oncogene. 1999;18:1245-1249.
21. Mori Y, Selaru FM, Sato F, et al. The impact of microsatellite instability on the molecular phenotype of colorectal tumors. Cancer Res. 2003;63:4577-4582.
22. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004;96:261-268.
23. Kuismanen SA, Moisio AL, Schweizer P, et al. Endometrial and colorectal tumours from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. Am J Pathol. 2002;160:1953-1958.
24. González-Aguilera JJ, Nejda N, Fernández FJ, et al. Genetic alterations and MSI status in primary, synchronous, and metachronous tumours in a family with hereditary non polyposis colorectal cancer (HNPCC). Am J Clin Oncol. 2003;26:386-391.
25. Kahn SM, Jiang W, Culbertson TA, et al. Rapid and sensitive nonradiactive detection of mutant KRAS genes via 'enriched' PCR amplification. Oncogene. 1991;6:1079-1083.
26. González-Aguilera JJ, Oliart S, Moreno Azcoita M, et al. Simultaneous mutations in KRAS and TP53 are indicative of poor prognosis in sporadic colorectal cancer. Am J Clin Oncol. 2004;27:39-45.
27. Feeley KM, Fullard JF, Heneghan MA, et al. Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis. J Pathol. 1999;188:14-17.
28. Evans DG, Walsh S, Jeacock J, et al. Incidence of hereditary nonpolyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. Br J Surg. 1997;84:1281-1285.
29. Smith G, Carey FA, Beattie J, et al. Mutations in APC, Kirsten-ras and p53- alternative genetic pathways colorectal cancer. Proc Nat Acad Sci USA. 2002;99:9433-9438.
30. Vasen HFA, Mecklin JP, Khan PM, et al. The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum. 1991;34:424-425.
31. Vasen HFA, Watson P, Mecklin JP, et al. New clinical criteria for hereditary non-polyposis colorectal cancer (HNPCC, Lynch Syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology. 1999;116:1453-1456.
32. Risques RA, Moreno V, Ribas M, et al. Genetic pathways and genomewide determinants of clinical outcome in colorectal cancer. Cancer Res. 2003;63:7206-7214.
33. Halford S, Sasieni P, Rowan A, et al. Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. Cancer Res. 2002;62:53-57.
34. Laiho P, Launonen V, Lahermo P, et al. Low-level microsatellite instability in most colorectal carcinomas. Cancer Res. 2002;62:1166-1170.
35. Liu B, Nicolaides NC, Markowitz S, et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet. 1995;9:48-55.
36. Borresen AL, Lothe RA, Meling GI, et al. Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. Hum Mol Genet. 1995;4:2065-2072.
37. Lucci-Cordisco E, Zito I, Gensini F, et al. Hereditary nonpolyposis colorectal cancer and related conditions. Am J Med Genet. 2003;122:325-334.
38. Thibodeau SN, French AJ, Cunningham JM, et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res. 1998;58:1713-1718.
39. Veigl Ml, Kasturi L, Olechnowicz J, et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci USA. 1998;95:8698-8702.
40. Kane MF, Loda M, Gaida GM, et al. Methylation of hMLH1 promoter correlates with lack of MLH1 in sporadic tumours and mismatch repair-defective human tumours cell lines. Cancer Res. 1997;57:808-811.
41. Papadopoulos N, Nicolaides NC, Liu B, et al. Mutations of GTBP in genetically unstable cells. Science. 1995;268:1915-1917.
42. Whitehall VLJ, Walsh MD, Young J, et al. Methylation of O-6-Methylguanine DNA Methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res. 2001;61:827-830.
43. Dietmaier W, Wallinger S, Bocker T, et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res. 1997;57:4749-4756.
44. Georgiades IB, Curtis LJ, Morris RM, et al. Heterogeneity studies identify a subset of sporadic colorectal cancers without evidence for chromosomal or microsatellite instability. Oncogene. 1999;18:7933-7940.
45. Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumours in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology. 1996;111:307-317.
46. Jass JR, Whitehall VLJ, Young J, et al. Emerging concepts in colorectal neoplasia. Gastroenterology. 2002;123:862-876.