Choice of management strategy for colorectal cancer based on a diagnostic immunohistochemical test for defective mismatch repair

Gut

Volumn 45, Issue 3, 1999, Pages 409-415

  Cawkwell, L ^a   Gray, S ^b   Murgatroyd, H ^a   Sutherland, F ^a   Haine, L ^a   Longfellow, M ^b   O'Loughlin, S ^a   Cross, D ^b   Kronborg, O ^c   Fenger, C ^c   Mapstone, N ^a   Dixon, M ^a   Quirke, P ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Colorectal cancer; HMLH 1; HMSH2; Immunohistochemistry; Microsatellite instability; Mismatch repair

Indexed keywords

ADULT; AGED; ARTICLE; BASE MISPAIRING; CANCER GRADING; COLORECTAL CANCER; COMPLEMENT ACTIVATION; DIAGNOSTIC TEST; DNA REPAIR; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PATIENT SELECTION; PRIORITY JOURNAL;

EID: 0032789079     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.45.3.409     Document Type: Article

References (25)

1. 1 Lynch HT, Smyrk T, Lynch J. An update of HNPCC (Lynch syndrome). Cancer Genet Cytogenet 1997;93:84-99.
2. 2 Sankila R, Aaltonen LA, Jarvinen HJ, et al. Better survival rates in patients with hMLH1-associated hereditary colorectal cancer. Gastroenterology 1996;110:682-7.
3. 3 Fante R, Roncucci L, Di Gregorio C, et al. Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinoma. Cancer 1996;77:2013-21.
4. 4 Lynch HT, Smyrk T, Lynch JF. Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome). Int J Cancer 1996;69:38-43.
5. 5 Liu B, Parsons R, Papadopoulos N, et al. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 1996;2:169-74.
6. 6 Aaltonen LA, Peltomaki P, Leath FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260:812-16.
7. 7 Lothe RA, Peltomaki P, Meling GI, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993;53:5849-52.
8. 8 Bubb VJ, Curtis LJ, Cunningham C, et al. Microsatellite instability and the role of hMSH2 in sporadic colorectal cancer. Oncogene 1996;12:2641-9.
9. 9 Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-19.
10. 10 Sengupta SB, Yiu CY, Boulos PB, et al. Genetic instability in patients with metachronous colorectal cancers. Br J Surg 1997;84:996-1000.
11. 11 Branch P, Hampson R, Karran P. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res 1995; 55:2304-9.
12. 12 Boland CR. Roles of the DNA mismatch repair genes in colorectal tumorigenesis. Int J Cancer 1996;69:47-9.
13. 13 Cawkwell L, Quirke P. Comparison and development of DNA extraction methods for formalin-fixed, paraffin-embedded tissue [abstract]. J Pathol 1997;182(suppl):22A.
14. 14 Cawkwell L, Li D, Lewis FA, et al. Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction. Gastroenterology 1995;109: 465-71.
15. 15 Liu B, Farrington SM, Petersen GM, et al. Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995;1:348-52.
16. 16 Makela TP, Hellsten E, Vesa J, et al. An Alu variable polyA repeat polymorphism upstream of L-myc at lp32. Hum Mol Genet 1992;1:217.
17. 17 Spirio L, Nelson L, Ward K, et al. A CA-repeat polymorphism close to the adenomatous poyposis coli (APC) gene offers improved diagnostic testing for familial APC. Am J Hum Genet 1993;52:286-96.
18. 18 Cawkwell L, Lewis FA, Quirke P. Frequency of allele loss of DCC, p53, RB1, WT1, NF1, NM23 & APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br J Cancer 1994;70:813-18.
19. 19 Cawkwell L, Kennedy A, Lewis F, et al. Optimisation of a fluorescent assay for allelic imbalance and microsatellite instability [abstract]. J Pathol 1997;182(suppl):22A.
20. 20 Cawkwell L, Quirke P. Direct multiplex amplification of formalin-fixed, paraffin-embedded tissue biopsies [abstract]. J Pathol 1997;182(suppl):22A.
21. 21 Thibodeau SN, French AJ, Roche PC, et al. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 1996;56:4836-40.
22. 22 Dietmaier W, Wallinger S, Rocker T, et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res 1997;57: 4749-56.
23. 23 Thibodeau SN, French AJ, Cunningham JM, et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res 1998;58:1713-18.
24. 24 Kane MF, Loda M, Gaida GM, et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997;57:808-11.
25. 25 Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998;95:6870-5.