Effect of simulated Ito on guinea pig and canine ventricular action potential morphology

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 2, 2006, Pages

  Dong, Min ^a   Sun, Xiaoyin ^a   Prinz, Astrid A ^b   Wang, Hong Sheng ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Dynamic clamp; Transient outward current; Ventricular myocytes

Indexed keywords

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOG; ELECTROPHYSIOLOGY; EXPERIMENTAL MODEL; GUINEA PIG; HEART VENTRICLE FUNCTION; MATHEMATICAL ANALYSIS; MUSCLE CELL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; REPOLARIZATION;

ACTION POTENTIALS; ANIMALS; CALCIUM; CARDIAC PACING, ARTIFICIAL; CELL SEPARATION; DOGS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; GUINEA PIGS; HEART; HEART VENTRICLES; MALE; MODELS, STATISTICAL; MYOCARDIUM; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS;

EID: 33746835692     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00084.2006     Document Type: Article

References (36)

1. Barry DM, Xu H, Schuessler RB, and Nerbonne JM. Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 α subunit. Circ Res 83: 560-567, 1998.
2. K,slow. Am J Physiol Heart Circ Physiol 281: H1201-H1209, 2001.
3. to and action potential notch are smaller in left vs. right canine ventricular epicardium. Am J Physiol Heart Circ Physiol 271: H548-H561, 1996.
4. + current in guinea pig ventricular myocytes? Am J Physiol Heart Circ Physiol 284: H598-H604, 2003.
5. Gima K and Rudy Y. Ionic current basis of electrocardiographic waveforms: a model study. Circ Res 90: 889-896, 2002.
6. to1 in shaping action potential morphology and duration. Circ Res 87: 1026-1033, 2000.
7. to,s: early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 α subunit. Circ Res 87: 73-79, 2000.
8. 2+ currents coexist in guinea pig ventricular myocytes and are both blocked by mibefradil. Circ Res 86: 628-635, 2000.
9. + current on the guinea pig action potential. Circ Res 84: 964-972, 1999.
10. Hoppe UC, Marban E, and Johns DC. Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer. J Clin Invest 105: 1077-1084, 2000.
11. Hund TJ and Rudy Y. Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation 110: 3168-3174, 2004.
12. Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, Marban E, and Tomaselli GF. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78: 262-273, 1996.
13. Litovsky SH and Antzelevitch C. Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium. Circ Res 67: 615-627, 1990.
14. Litovsky SH and Antzelevitch C. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ Res 62: 116-126, 1988.
15. Ks contributes to the longer action potential of the M cell. Circ Res 76: 351-365, 1995.
16. Liu DW, Gintant GA, and Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, mid-myocardial, and endocardial myocytes from the free wall of the canine left-ventricle. Circ Res 72: 671-687, 1993.
17. Ks blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans. Circulation 104: 951-956, 2001.
18. Lukas A and Antzelevitch C. Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current. Circulation 88: 2903-2915, 1993.
19. Nabauer M, Beuckelmann DJ, Uberfuhr P, and Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93: 168-177, 1996.
20. to) in normal and diseased myocardium. J Mol Cell Cardiol 33: 851-872, 2001.
21. Pinto RD, Elson RC, Szucs A, Rabinovich MI, Selverston AI, and Abarbanel HD. Extended dynamic clamp: controlling up to four neurons using a single desktop computer and interface. J Neurosci Methods 108: 39-48, 2001.
22. Priebe L and Beuckelmann DJ. Simulation study of cellular electric properties in heart failure. Circ Res 82: 1206-1223, 1998.
23. Qin D, Zhang ZH, Caref EB, Boutjdir M, Jain P, and el-Sherif N. Cellular and ionic basis of arrhythmias in postinfarction remodeled ventricular myocardium. Circ Res 79: 461-473, 1996.
24. Ramirez RJ, Nattel S, and Courtemanche M. Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am J Physiol Heart Circ Physiol 279: H1767-H1785, 2000.
25. Rosati B, Grau F, Rodriguez S, Li H, Nerbonne JM, and McKinnon D. Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol 548: 815-822, 2003.
26. 2+ in rat and human ventricular myocytes. J Physiol 511: 827-836, 1998.
27. to) in shaping canine ventricular action potential - a dynamic clamp study. J Physiol 564: 411-419, 2005.
28. Tomaselli GF and Marban E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42: 270-283, 1999.
29. Tomaselli GF, Beuckelmann DJ, Calkins HG, Berger RD, Kessler PD, Lawrence JH, Kass D, Feldman AM, and Marban E. Sudden cardiac death in heart failure. The role of abnormal repolarization. Circulation 90: 2534-2539, 1994.
30. Wang HS and Cohen IS. Calcium channel heterogeneity in canine left ventricular myocytes. J Physiol 547: 825-833, 2003.
31. + current in rabbit and human atrial myocytes. Circ Res 84: 551-561, 1999.
32. Wickenden AD, Kaprielian R, Kassiri Z, Tsoporis JN, Tsushima R, Fishman GI, and Backx PH. The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure. Cardiovasc Res 37: 312-323, 1998.
33. 2+ on Kv4 PH.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes. Cell Physiol Biochem 9: 11-28, 1999.
34. Winslow RL, Rice J, Jafri S, Marban E, and O'Rourke B. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84: 571-586, 1999.
35. + currents in adult mouse ventricular myocytes. J Gen Physiol 113: 661-678, 1999.
36. + solution. Am J Physiol Cell Physiol 287: C1396-C1403, 2004.