Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 12, 2006, Pages 4208-4216

  Lawson, Edward C ^a   Santulli, Rosemary J ^a   Dyatkin, Alexey B ^a   Ballentine, Scott A ^a   Abraham, William M ^b   Rudman, Sandra ^c   Page, Clive P ^c   de Garavilla, Lawrence ^a   Damiano, Bruce P ^a   Kinney, William A ^a   Maryanoff, Bruce E ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antagonist; Integrin; VLA 4

Indexed keywords

2 AZABICYCLO[2.2.2]OCTANE DERIVATIVE; ALPHA4 BETA1 INTEGRIN ANTAGONIST; ANTIASTHMATIC AGENT; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; FUSED HETEROCYCLIC RINGS; OVALBUMIN;

AIRWAY RESISTANCE; ALLERGIC ASTHMA; ANIMAL CELL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; HYPERSENSITIVITY REACTION; INFLAMMATORY CELL; MALE; NONHUMAN; SHEEP; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CELL ADHESION; CELL LINE; CHEMISTRY; CONFORMATION; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; INHALATIONAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG FUNCTION TEST; PATHOPHYSIOLOGY; RESPIRATORY SYSTEM;

CAVIA; OVIS ARIES;

ADMINISTRATION, INHALATION; ANIMALS; ANTI-ASTHMATIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CELL ADHESION; CELL LINE; DRUG ADMINISTRATION SCHEDULE; GUINEA PIGS; HUMANS; INJECTIONS, INTRAPERITONEAL; INTEGRIN ALPHA4BETA1; MALE; MOLECULAR CONFORMATION; OVALBUMIN; RESPIRATORY FUNCTION TESTS; RESPIRATORY SYSTEM; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746789912     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.067     Document Type: Article

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