Impaired quality of life in hypopituitary adults with growth hormone deficiency: Can somatropin replacement therapy help?

Treatments in Endocrinology

Volumn 5, Issue 4, 2006, Pages 243-250

  Deijen, Jan Berend ^a   Arwert, Lucia I ^b  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; GROWTH HORMONE; HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ANXIETY; CLINICAL TRIAL; DEPRESSION; GROWTH HORMONE DEFICIENCY; HEALTH STATUS; HEALTH SURVEY; HORMONE SUBSTITUTION; HUMAN; HYPOPITUITARISM; MENTAL HEALTH; META ANALYSIS; MOOD CHANGE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; REVIEW; SYSTEMATIC REVIEW; WELLBEING; ADULT; CHEMICALLY INDUCED;

ADULT; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; QUALITY OF LIFE; SURVEYS AND QUESTIONNAIRES;

EID: 33746733560     PISSN: 11756349     EISSN: 11756349     Source Type: Journal    
DOI: 10.2165/00024677-200605040-00005     Document Type: Review

References (51)

1. de Boer H, Blok GJ, van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995 Feb; 16 (1): 63-86
2. Richert S, Strauss A, Fahlbusch R, et al. Psychopathologic symptoms and personality traits in patients with florid acromegaly. Schweiz Arch Neurol Psychiatr 1987; 138: 61-86
3. Stouthart PJ, Deijen JB, Roffel M, et al. Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy. Psychoneuroendocrinology 2003 Jul; 28 (5): 612-26
4. Nyberg F, Burman P. Growth hormone and its receptors in the central nervous system: location and functional significance. Horm Res 1996; 45 (1-2): 18-22
5. Nyberg F. Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000 Oct; 21 (4): 330-48
6. Adem A, Jossan SS, d'Argy R, et al. Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization. Brain Res 1989 Dec; 503 (2): 299-303
7. Burman P, Hetta J, Wide L, et al. Growth hormone treatment affects brain neurotransmitters and thyroxine. Clin Endocrinol (Oxf) 1996 Mar; 44 (3): 319-24
8. Risby ED, Hsiao JK, Sunderland T, et al. The effects of antidepressants on the cerebrospinal fluid homovanillic acid/5-hydroxyindoleacetic acid ratio. Clin Pharmacol Ther 1987 Nov; 42 (5): 547-54
9. Erlanger DM, Kutner KC, Jacobs AR. Hormones and cognition: current concepts and issues in neuropsychology. Neuropsychol Rev 1999 Dec; 9 (4): 175-207
10. Muldoon MF, Barger SD, Flory JD, et al. What are quality of life measurements measuring? BMJ 1998 Feb; 316 (7130): 542-5
11. McGauley G, Cuneo R, Salomon F, et al. Growth hormone deficiency and quality of life. Horm Res 1996; 45 (1-2): 34-7
12. Gill TM, Feinstein AR. A critical appraisal of the quality of quality-of-life measurements. JAMA 1994 Aug; 272 (8): 619-26
13. Smith KW, Avis NE, Assmann SF. Distinguishing between quality of life and health status in quality of life research: a meta-analysis. Qual Life Res 1999 Aug; 8 (5): 447-59
14. Bradley C. Importance of differentiating health status from quality of life. Lancet 2001 Jan; 357 (9249): 7-8
15. McKenna SP, Doward LC, Alonso J, et al. The QoL-AGHDA: an instrument for the assessment of quality of life in adults with growth hormone deficiency. Qual Life Res 1999 Jun; 8 (4): 373-83
16. Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care 1992 Jun; 30 (6): 473-83
17. Dupuy HJ. The psychological general well-being (PGWB) index. In: Wenger NK, Matsson ME, Furberg CF, et al., editors. Assessment of quality of life in clinical trials of cardiovascular therapies. New York: Le Jacq, 1984: 170-83
18. Johnston DG. Growth hormone deficiency and quality of life in hypopituitary adults. Clin Endocrinol (Oxf) 1997 Apr; 46 (4): 407-8
19. Burman P, Deijen JB. Quality of life and cognitive function in patients with pituitary insufficiency. Psychother Psychosom 1998; 67 (3): 154-67
20. Deijen JB, de Boer H, Blok GJ, et al. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology 1996 Apr; 21 (3): 313-22
21. Attanasio AF, Lamberts SW, Matranga AM, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment: Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab 1997 Jan; 82 (1): 82-8
22. Lynch S, Merson S, Beshyah SA, et al. Psychiatric morbidity in adults with hypopituitarism. J R Soc Med 1994 Aug; 87 (8): 445-7
23. Wallymahmed ME, Foy P, MacFarlane IA. The quality of life of adults with growth hormone deficiency: comparison with diabetic patients and control subjects. Clin Endocrinol (Oxf) 1999 Sep; 51 (3): 333-8
24. Page RC, Hammersley MS, Burke CW, et al. An account of the quality of life of patients after treatment for non-functioning pituitary tumours. Clin Endocrinol (Oxf) 1997 Apr; 46 (4): 401-6
25. Bjork S, Jonsson B, Westphal O, et al. Quality of life of adults with growth hormone deficiency: a controlled study. Acta Paediatr Scand Suppl 1989; 356: 55-9
26. Rosen T, Wiren L, Wilhelmsen L, et al. Decreased psychological well-being in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf) 1994 Jan; 40 (1): 111-6
27. Dean HJ, McTaggart TL, Fish DG, et al. The educational, vocational, and marital status of growth hormone-deficient adults treated with growth hormone during childhood. Am J Dis Child 1985 Nov; 139 (11): 1105-10
28. Bülow B, Hagmar L, Orbaek P, et al. High incidence of mental disorders, reduced mental well-being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease. Clin Endocrinol (Oxf) 2002 Feb; 56 (2): 183-93
29. McMillan CV, Bradley C, Gibney J, et al. Psychological effects of withdrawal of growth hormone therapy from adults with growth hormone deficiency. Clin Endocrinol (Oxf) 2003 Oct; 59 (4): 467-75
30. Raben MS. Growth hormone: 2. Clinical use of human growth hormone. N Engl J Med 1962 Jan; 266: 82-6
31. McGauley GA. Quality of life assessment before and after growth hormone treatment in adults with growth hormone deficiency. Acta Paediatr Scand Suppl 1989; 356: 70-2
32. Gibney J, Wallace JD, Spinks T, et al. The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients. J Clin Endocrinol Metab 1999 Aug; 84 (8): 2596-602
33. Blau TH. Quality of life, social indicators, and criteria of change. Profess Psychol 1977; 8: 464-73
34. Arwert LI, Deijen JB, Müller M, et al. Long-term growth hormone treatment preserves GH-induced memory and mood improvements: a 10-year follow-up study in GH-deficient adult men. Horm Behav 2005 Mar; 47 (3): 343-9
35. Arwert LI, Deijen JB, Drent ML. Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and elderly subjects. Nutr Neurosci 2003 Oct; 6 (5): 269-75
36. Giusti M, Meineri L, Malagamba D, et al. Impact of recombinant human growth hormone treatment on psychological profiles in hypopituitary patient with adult-onset growth hormone deficiency. Eur J Clin Invest 1998; 28 (1): 13-9
37. Ahmad AM, Hopkins MT, Thomas J, et al. Body composition and quality of life in adults with growth hormone deficiency; effects of low dose growth hormone replacement. Clin Endocinol 2001; 54: 709-17
38. Arwert LI, Deijen JB, Witlox J, et al. The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: a meta-analysis. Growth Horm IGF Res 2005 Feb; 15 (1): 47-54
39. Baum HB, Katznelson L, Sherman JC, et al. Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. J Clin Endocrinol Metab 1998 Sep; 83 (9): 3184-9
40. Burman P, Broman JE, Hetta J, et al. Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. J Clin Endocrinol Metab 1995 Dec; 80 (12): 3585-90
41. Carroll PV, Littlewood R, Weissberger AJ, et al. The effects of two doses of replacement growth hormone on the biochemical, body composition and psychological profiles of growth hormone-deficient adults. Eur J Endocrinol 1997 Aug; 137 (2): 146-53
42. Cuneo RC, Judd S, Wallace JD, et al. The Australian multicenter trial of growth hormone (GH) treatment in GH-deficient adults. J Clin Endocrinol Metab 1998 Jan; 83 (1): 107-16
43. Degerblad M, Almkvist O, Grunditz R, et al. Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency. Acta Endocrinol (Copenh) 1990 Aug; 123 (2): 185-93
44. Deijen JB, de Boer H, van der Veen EA. Cognitive changes during growth hormone replacement in adult men. Psychoneuroendocrinology 1998 Jan; 23 (1): 45-55
45. Hernberg-Stahl E, Luger A, Abs R, et al. Healthcare consumption decreases in parallel with improvements in quality of life during GH replacement in hypopituitary adults with GH deficiency. J Clin Endocrinol Metab 2001 Nov; 86 (11): 5277-81
46. Murray RD, Skillicorn CJ, Howell SJ, et al. Influences on quality of life in GH deficient adults and their effect on response to treatment. Clin Endocrinol (Oxf) 1999 Nov; 51 (5): 565-73
47. Sartorio A, Molinari E, Riva G, et al. Growth hormone treatment in adults with childhood onset growth hormone deficiency: effects on psychological capabilities. Horm Res 1995; 44 (1): 6-11
48. Soares CN, Musolino NR, Cunha NM, et al. Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropyschological and clinical profiles of GH deficient adults: a placebo-controlled trial. Arq Neuropsiquiatr 1999 Jun; 57 (2A): 182-9
49. Wallymahmed ME, Foy P, Shaw D, et al. Quality of life, body composition and muscle strength in adult growth hormone deficiency: the influence of growth hormone replacement therapy for up to 3 years. Clin Endocrinol (Oxf) 1997 Oct; 47 (4): 439-46
50. Wiren L, Bengtsson BA, Johannsson G. Beneficial effects of long-term GH replacement therapy on quality of life in adults with GH deficiency. Clin Endocrinol (Oxf) 1998 May; 48 (5): 613-20
51. Deijen JB, Arwert LI, Witlox J, et al. Differential effect sizes of growth hormone replacement on quality of life, well-being and health status in growth hormone deficient patients: a meta-analysis. Health Qual Life Outcomes 2005 Oct; 3: 63-70