The Australian multicenter trial of growth hormone (GH) treatment in GH- deficient adults

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 1, 1998, Pages 107-116

  Cuneo, Ross C ^b   Judd, Steve ^a   Wallace, Jennifer D ^b   Perry Keene, Don ^c   Burger, Henry ^d   Lim Tio, Sylvia ^d   Strauss, Boyd ^d   Stockigt, Jan ^e   Topliss, Duncan ^e   Alford, Frank ^f   Hew, L ^f   Bode, Hans ^g   Conway, Ann ^h   Handelsman, David ^h   Dunn, Stewart ⁱ   Boyages, Steve ^j   Cheung, N Wah ^j   Hurley, David ^k  

^a FLINDERS MEDICAL CENTRE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d MONASH MEDICAL CENTRE   (Australia)

^e ALFRED HOSPITAL   (Australia)

^f ST VINCENT S HOSPITAL   (Australia)

^g SYDNEY CHILDREN'S HOSPITAL   (Australia)

^h ROYAL PRINCE ALFRED HOSPITAL   (Australia)

ⁱ UNIVERSITY OF SYDNEY   (Australia)

^j WESTMEAD HOSPITAL   (Australia)

^k ROYAL PERTH HOSPITAL   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; RECOMBINANT GROWTH HORMONE;

ADOLESCENT; ADULT; AGED; ARTHRALGIA; ARTICLE; AUSTRALIA; BODY FAT; BODY MASS; BONE DENSITY; BONE MINERALIZATION; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DUAL ENERGY X RAY ABSORPTIOMETRY; EDEMA; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE WEAKNESS; MYALGIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TENDINITIS;

ADULT; ANALYSIS OF VARIANCE; AUSTRALIA; BLOOD PRESSURE; BONE DENSITY; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DEXAMETHASONE; DOUBLE-BLIND METHOD; EMOTIONS; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PLACEBOS; QUALITY OF LIFE; RECOMBINANT PROTEINS; TRIGLYCERIDES; WATER-ELECTROLYTE BALANCE;

EID: 14444282422     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.1.107     Document Type: Article

References (45)

1. Christiansen JS, Jørgensen JOL. 1991 Beneficial effects of GH replacement therapy in adults. Acta Endocrinol (Copenh). 125:7-13.
2. Cuneo RC, Salomon F, McGauley GA, Sönksen PH. 1992 The growth hormone deficiency syndrome in adults. Clin Endocrinol (Oxf). 37:387-397.
3. Rosén T, Bengtsson B. 1991 Body composition in patients treated for hypopituitarism. J Endocrinol Invest. 14[Suppl 1]:P50. (Abstract).
4. Cuneo RC, Salomon F, Wiles CM, Sönksen PH. 1990 Skeletal muscle performance in adults with growth hormone deficiency. Horm Res. 33[Suppl 4]:55-60.
5. McGauley GA, Cuneo RC, Salomon F, Sönksen PH. 1990 Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency. Horm Res. 33[Suppl 4]:52-54.
6. Kaufman J-M, Taelman P, Vermeulen A, Vandeweghe M. 1992 Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab. 74:118-123.
7. Rosén T, Bengtsson B. 1990 Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 336:285-288.
8. Cuneo RC, Salomon F, Watts GF, Hesp R, Sönksen PH. 1993 Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism. 42:1519-1523.
9. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol. 70:688-694.
10. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol. 70:695-700.
11. Cuneo RC, Salomon F, Wiles CM, et al. 1992 Histology of skeletal muscle in adults with GH deficiency: comparison with normal muscle and response to GH treatment. Horm Res. 37:23-28.
12. Cuneo RC, Salomon F, Wilmshurst P, et al. 1991 Cardiovascular effects of growth hormone treatment in growth-hormone-deficient adults: stimulation of the renin-aldosterone system. Clin Sci. 81:587-592.
13. Björk S, Jönsson B, Westphal O, Levin J-E. 1989 Quality of life of adults with growth hormone deficiency: a controlled study. Acta Pædiatr Scand Suppl. 356:55-59.
14. Takano K, Tanaka T, Saito T, Committee for the Study Group of Adult GH Deficiency. 1994 Psychosocial adjustment in a large cohort of adults with growth hormone deficiency treated with growth hormone in childhood: summary of a questionnaire survey. Acta Paediatr Suppl. 399:16-19.
15. Jorgensen JOL, Pedersen SA, Thuesen L, et al. 1991 Long-term growth hormone treatment in growth hormone deficient adults. Acta Endocrinol (Copenh). 125:449-453.
16. Attanasio AF, Lamberts SW, Matranga AM, et al. 1997 Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab. 82:82-88.
17. Hoffman DM, O'Sullivan AJ, Baxter RC, Ho KKY. 1994 Diagnosis of growth-hormone deficiency in adults. Lancet. 343:1064-1068.
18. Jørgensen JOL, Pedersen SA, Thuesen L, et al. 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet. 1:1221-1225.
19. Salomon F, Cuneo RC, Hesp R, Sönksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 321:1797-1803.
20. Whitehead HM, Boreham C, McIlrath EM, et al. 1992 Growth hormone treatment in adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clin Endocrinol. 36:45-52.
21. Bengtsson B, Edén S, Lönn L, et al. 1993 Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab. 76:309-317.
22. Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. 1986 Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol. 60:1327-1332.
23. Lukaski HC, Bolonchuk WW. 1988 Estimation of body fluid volumes using tetrapolar bioelectrical impedance measurements. Aviat Space Environ Med 1163-1169.
24. Forbes GB. 1962 Methods for determining composition of the human body. Pediatrics. 29:477-494.
25. Boddy K, King PC, Hume R, Weyers E. 1972 The relationship of total body potassium to height, weight, and age in normal adults. J Clin Pathol. 25:512-517.
26. Mitchell RA, Imperial E, Zhuo D, et al. 1992 A cross-cultural assessment of perceived health problems in the elderly. Disabil Rehabil. 14:133-135.
27. Baum FE, Cooke RD. 1989 Community health needs assessment: use of the Nottingham Health Profile in an Australian study. Med J Aust. 150:587-590.
28. Toogood AA, Beardwell CG, Shalet SM. 1994 The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clin Endocrinol (Oxf). 41:511-516. [Published errata appear in Clin Endocrinol (Oxf) 1994 41:845 and Clin Endocrinol (Oxf) 1995 42:109] [see comments].
29. Cheung NW, Liddle C, Coverdale S, Lou JC, Boyages SC. 1996 Growth hormone treatment increases cytochrome P450-mediated antipyrine clearance in man. J Clin Endocrinol Metab. 81:1999-2001.
30. Weissberger AJ, Verikiou K, Sönksen PH. 1994 Diagnosis of growth hormone deficiency in adults. Lancet. 344:483.
31. Hindmarsh PC, Smith PJ, Pringle PJ, Brook CG. 1988 The relationship between the response to growth hormone therapy and pre-treatment growth hormone secretory status. Clin Endocrinol (Oxf). 28:559-563.
32. Russell-Jones DL, Watts GF, Weissberger A, et al. 1994 The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adults growth hormone deficient patients. Clin Endocrinol (Oxf). 41:345-350.
33. O'Neal D, Hew FL, Sikaris K, Ward G, Alford F, Best JD. 1996 Low density lipoprotein particle size in hypopituitary adults receiving conventional hormone replacement therapy. J Clin Endocrinol Metab. 81:2448-2454.
34. Wüster C, Slenczka E, Ziegler R. 1991 Increased prevalence of osteoporosis and arteriosclerosis in patients with conventionally substituted pituitary insufficiency: is there a need for additional growth hormone substitution. Klin Wochenschr. 69:769-773.
35. Fowelin J, Attvall S, Lager I, Bengtsson B. 1993 Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism. 42:1443-1447.
36. O'Neal DN, Kalfas A, Dunning PL, et al. 1994 The effect of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucosemediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis. J Clin Endocrinol Metab. 79:975-983.
37. Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. 1990 Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis. 10:497-511.
38. De Boer H, Blok G-J, van der Veen EA. 1995 Clinical aspects of growth hormone deficiency in adults. Endocr Rev. 16:63-86.
39. Haeusler G, Frisch H, Schmitt K, et al. 1995 Treatment of patients with Ullrich-Turner syndrome with conventional doses of growth hormone and the combination with testosterone or oxandrolone: effect on growth, IGF-I and IGFBP-3 concentrations. Eur J Pediatr. 154:437-444.
40. Holmes SJ, Shalet SM. 1995 Which adults develop side-effects of growth hormone replacement? Clin Endocrinol (Oxf). 43:143-149.
41. Vandeweghe M, Taelman P, Kaufman J. 1993 Short and long-term effects of growth hormone treatment on bone turnover and mineral content in adults with growth hormone deficiency. Clin Endocrinol (Oxf). 39:409-415.
42. Rosén T, Wirén L, Wilhelmsen L, Wiklund I, Bengtsson B-A. 1994 Decreased psychological well-being in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf). 40:111-116.
43. Dean HJ, McTaggart TL, Fish DG, Friesen HG. 1985 The educational, vocational, and marital status of growth hormone-deficient adults treated with growth hormone during childhood. Am J Dis Child. 139:1105-1110.
44. Rikken B, van Busschbach J, le Cessie S, et al. 1995 Impaired social status of growth hormone deficient adults as compared to controls with short or normal stature. Clin Endocrinol (Oxf). 43:205-211.
45. Weaver JU, Thaventhiran L, Noonan K, et al. 1994 The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults. Clin Endocrinol (Oxf). 41:639-648.