High-load, oligomeric phosphonyl dichloride: facile generation via ROM polymerization and application to scavenging amines

Tetrahedron Letters

Volumn 47, Issue 36, 2006, Pages 6429-6432

  Herpel, Russell H ^a,b   Vedantham, Punitha ^a,b   Flynn, Daniel L ^c   Hanson, Paul R ^a,b  

^a UNIVERSITY OF KANSAS   (United States)

^b Center for Chemical Methodology and Library Development   (United States)

^c Deciphera Pharmaceuticals LLC   (United States)

Author keywords

High load polymer; Insoluble polymer; Phosphonic dichloride; Phosphonyl dichloride; Ring opening metathesis polymerization (ROMP); Scavenging agent; Supported reagents

Indexed keywords

AMINE; BICYCLO[2.2.1]HEPT 5 EN 2 YLPHOSPHONIC DICHLORIDE; CYCLOPENTADIENE DERIVATIVE; PHOSPHONYL DICHLORIDE; SCAVENGER; UNCLASSIFIED DRUG; VINYL CHLORIDE;

ARTICLE; DIELS ALDER REACTION; DRUG SELECTIVITY; HIGH THROUGHPUT SCREENING; MICROWAVE COOKING; OLIGOMERIZATION; REAGIN TEST; RING OPENING; RING OPENING METATHESIS POLYMERIZATION; ROOM TEMPERATURE; STEREOCHEMISTRY; SYNTHESIS;

BETULACEAE;

EID: 33746698339     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.06.130     Document Type: Article

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22. 3).
23. 2 as a filter aid can remedy this problem.
24. 1H NMR spectra of all crude products are available in the Supplementary data.
25. 3N as a base.