Control of single channel conductance in the outer vestibule of the Kv2.1 potassium channel

Journal of General Physiology

Volumn 128, Issue 2, 2006, Pages 231-246

  Trapani, Josef G ^a   Andalib, Payam ^a   Consiglio, Joseph F ^a   Korn, Stephen J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; POTASSIUM CHANNEL;

ARTICLE; CONDUCTANCE; DATA ANALYSIS; ELECTROCHEMISTRY; MEDICAL RESEARCH; VESTIBULE;

ALGORITHMS; AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; ION CHANNEL GATING; LYSINE; MARKOV CHAINS; MEMBRANE POTENTIALS; MUTATION; PATCH-CLAMP TECHNIQUES; POTASSIUM; PROTEIN CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; SHAB POTASSIUM CHANNELS; TRANSFECTION;

EID: 33746618825     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200509465     Document Type: Article

References (40)

1. Andalib, P., M.J. Wood, and S.J. Korn. 2002. Control of outer vestibule dynamics and current magnitude in the Kv2.1 potassium channel. J. Gen. Physiol. 120:739-755.
2. Bao, H., A. Hakeem, M. Henteleff, J.G. Starkus, and M.D. Rayner. 1999. Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels. J. Gen. Physiol. 113:139-151.
3. + channels? Circ. Res. 77:361-369.
4. + channel. Nature. 414:73-77.
5. Brelidze, T.I., and K.L. Magleby. 2005. Probing the geometry of the inner vestibule of BK channels with sugars. J. Gen. Physiol. 126:105-121.
6. Brelidze, T.I., X. Niu, and K.L. Magleby. 2003. A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Proc. Natl. Acad. Sci. USA. 100:9017-9022.
7. Chapman, M.L., H.M. VanDongen, and A.M. VanDongen. 1997. Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating. Biophys. J. 72:708-719.
8. Chapman, M.L., H.S. Krovetz, and A.M. VanDongen. 2001. GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. J. Physiol. 530:21-33.
9. Chung, S.H., J.B. Moore, L.G. Xia, L.S. Premkumar, and P.W. Gage. 1990. Characterization of single channel currents using digital signal processing techniques based on Hidden Markov Models. Philos. Trans. R. Soc. Lond. B Biol. Sci. 329:265-285.
10. Chung, S.H., V. Krishnamurthy, and J.B. Moore. 1991. Adaptive processing techniques based on hidden Markov models for characterizing very small channel currents buried in noise and deterministic interferences. Philos. Trans. R. Soc. Lond. B Biol. Sci. 334:357-384.
11. Chung, S.H., T.W. Allen, and S. Kuyucak. 2002. Modeling diverse range of potassium channels with Brownian dynamics. Biophys. J. 83:263-277.
12. Consiglio, J.F., and S.J. Korn. 2004. Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channel. J. Gen. Physiol. 123:387-400.
13. + with the outer vestibule. J. Gen. Physiol. 121:111-124.
14. + channel, Kv2.1, is apposed to astrocytic processes and is associated with inhibitory postsynaptic membranes in hippocampal and cortical principal neurons and inhibitory interneurons. Neuroscience. 84:37-48.
15. + channel subunit Kv2.1. J. Physiol. 522:19-31.
16. + conduction by external surface charge effect. J. Gen. Physiol. 124:173-184.
17. Horn, R. 1991. Diffusion of nystatin in plasma membrane is inhibited by a glass-membrane seal. Biophys. J. 60:329-333.
18. +-dependent modulation of tetraethylammonium efficacy in Kv2.1 potassium channels. J. Gen. Physiol. 115:509-518.
19. Immke, D., M. Wood, L. Kiss, and S.J. Korn. 1999. Potassium-dependent changes in the conformation of the Kv2.1 potassium channel pore. J. Gen. Physiol. 113:819-836.
20. Jurman, M.E., L.M. Boland, Y. Liu, and G. Yellen. 1994. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques. 17:876-881.
21. Korn, S.J., and J.G. Trapani. 2005. Potassium channels. IEEE Trans Nanobioscience. 4:21-33.
22. Li, W., and R.W. Aldrich. 2004. Unique inner pore properties of BK channels revealed by quaternary ammonium block. J. Gen. Physiol. 124:43-57.
23. + channel. Pflugers Arch. 435:654-661.
24. + channel with backbone mutations in the selectivity filter. Nat. Neurosci. 4:239-246.
25. + channel families regulate insulin secretion. Mol. Endocrinol. 15:1423-1435.
26. + channels. Science. 250:276-279.
27. + currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons. J. Neurosci. 22:10094-10105.
28. Mitterdorfer, J., and B.P. Bean. 2002. Potassium currents during the action potential of hippocampal CA3 neurons. J. Neurosci. 22:10106-10115.
29. + selectivity filter. Nature. 414:37-42.
30. Muennich, E.A., and R.E. Fyffe. 2004. Focal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneurones. J. Physiol. 554:673-685.
31. + current in rat hippocampal neurons. J. Neurosci. 19:1728-1735.
32. Nimigean, C.M., J.S. Chappie, and C. Miller. 2003. Electrostatic tuning of ion conductance in potassium channels. Biochemistry. 42:9263-9268.
33. +-channel activation gating. Science. 285:73-78.
34. Schoppa, N.E., and F.J. Sigworth. 1998. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol. 111:313-342.
35. + channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity. J. Physiol. 531:37-50.
36. + pores. Pflugers Arch. 423:104-112.
37. Trapani, J.G., and S.J. Korn. 2003. Control of ion channel expression for patch clamp recordings using an inducible expression system in mammalian cell lines. BMC Neurosci. 4:15.
38. VanDongen, A.M. 2004. K channel gating by an affinity-switching selectivity filter. Proc. Natl. Acad. Sci. USA. 101:3248-3252.
39. +- dependent potentiation in Kv2.1 potassium channels. Biophys. J. 79:2535-2546.
40. Zheng, J., and F.J. Sigworth. 1998. Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels. J. Gen. Physiol. 112:457-474.