Focal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneurones

Journal of Physiology

Volumn 554, Issue 3, 2004, Pages 673-685

  Muennich, Elizabeth A L ^a   Fyffe, Robert E W ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MUSCARINIC M2 RECEPTOR; POTASSIUM ION; VOLTAGE GATED POTASSIUM CHANNEL; MUSCARINIC RECEPTOR; SHAB POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL KV2.1;

ACTION POTENTIAL; ALPHA NERVE FIBER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; CHOLINERGIC NERVE; DENDRITE; GLIA CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERNEURON; MALE; MAMMAL; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE; NERVE PROJECTION; NONHUMAN; POTASSIUM CURRENT; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; RENSHAW CELL; REPOLARIZATION; SPINAL CORD MOTONEURON; SYNAPSE; ULTRASTRUCTURE; ANTIBODY LABELING; CELL MEMBRANE; CELL POPULATION; GLIA; NERVE CELL; NERVE ENDING; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AFFERENT PATHWAYS; ANIMALS; DELAYED RECTIFIER POTASSIUM CHANNELS; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MALE; MICROSCOPY, IMMUNOELECTRON; MOTOR NEURONS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, SPRAGUE-DAWLEY; SHAB POTASSIUM CHANNELS; SPINAL CORD; SYNAPSES;

EID: 1242273894     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.056192     Document Type: Article

References (55)

1. Alaburda A, Perrier JF & Hounsgaard J (2002). An M-like outward current regulates the excitability of spinal motoneurones in the adult turtle. J Physiol 540, 875-881.
2. Alvarez FJ, Dewey DE, Harrington DA & Fyffe REW (1997). Cell-type specific organization of glycine receptor clusters in the mammalian spinal cord. J Comp Neurol 379, 150-170.
3. Alvarez FJ, Dewey DE, McMillin P & Fyffe REW (1999). Distribution of cholinergic contacts on Renshaw cells in the rat spinal cord, a light microscopic study. J Physiol 515, 787-797.
4. Antonucci DE, Lim ST, Vassanelli S & Trimmer JS (2001). Dynamic localization and clustering of dendritic Kv2.1 voltage-dependent potassium channels in developing hippocampal neurons. Neuroscience 108, 69-81.
5. Bekkers JM (2000a). Properties of voltage-gated potassium currents in nucleated patches from large layer 5 cortical pyramidal neurons of the rat. J Physiol 525, 593-609.
6. Bekkers JM (2000b). Distribution and activation of voltage-gated potassium channels in cell-attached and outside-out patches from large layer 5 cortical pyramidal neurons of the rat. J Physiol 525, 611-620.
7. Blaine JT & Ribera AB (2001). Kv2 channels form delayed-rectifier potassium channels in situ. J Neurosci 21, 1473-1480.
8. Brännström T (1993). Quantitative synaptology of functionally different types of cat medial gastrocnemius alpha-motoneurons. J Comp Neurol 330, 439-454.
9. Carr PA, Alvarez FJ, Leman EA & Fyffe REW (1998). Calbindin D28k expression in immunohistochemically identified Renshaw cells. Neuroreport 9, 2657-2661.
10. Chen XY & Wolpaw JR (1994). Triceps surae motoneuron morphology in the rat, a quantitative light microscopic study. J Comp Neurol 343, 143-157.
11. Choquet D & Triller A (2003). The role of receptor diffusion in the organization of the postsynaptic membrane. Nat Rev Neurosci 4, 251-265.
12. Conradi S (1969). Ultrastructure and distribution of neuronal and glial elements on the motoneuron surface in the lumbosacral spinal cord of the adult cat. Acta Physiol Scand Suppl 332, 5-48.
13. Conradi S, Kellerth JO & Berthold CH (1979). Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. II. A method for the description of architecture and synaptology of the cell body and proximal dendritic segments. J Comp Neurol 184, 741-754.
14. Cooper EC, Harrington E, Jan YN & Jan LY (2001). M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 21, 9529-9540.
15. + channel, Kv2.1, is apposed to astrocytic processes and is associated with inhibitory postsynaptic membranes in hippocampal and cortical principal neurons and inhibitory interneurons. Neuroscience 84, 37-48.
16. Fyffe REW (2001). Synaptic motoneurons, synaptic inputs and receptor organization. In Motor Neurobiology of the Spinal Cord, ed.Cope T, pp. 21-46. CRC Press, Boca Raton.
17. Fyffe REW, Ream LJ, Dewey R & Lujan R (2002). Differential distribution of Kv2.1 in spinal neurons. FENS Abstr. 1, A216.4.
18. Gao BX & Ziskind-Conhaim L (1998). Development of ionic currents underlying changes in action potential waveforms in rat spinal motoneurons. J Neurophysiol 80, 3047-3061.
19. Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL & Nathanson NM (1997). Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci U S A 94, 13311-13316.
20. Hellström J, Arvidsson U, Elde R, Cullheim S & Meister B (1999). Differential expression of nerve terminal protein isoforms in VAChT-containing varicosities of the spinal cord ventral horn. J Comp Neurol 411, 578-590.
21. Hellström J, Oliveira AL, Meister B & Cullheim S (2003). Large cholinergic nerve terminals on subsets of motoneurons and their relation to muscarinic receptor type 2. J Comp Neurol 460, 476-486.
22. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387, 869-875.
23. Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg LK, Yoneda Y, Scott JD, Brown DA & Higashida H (2003). AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci 6, 564-571.
24. Kellerth JO, Berthold CH & Conradi S (1979). Electron microscopic studies of serially sectioned cat spinal alpha-motoneurons. III. Motoneurons innervating fast-twitch (type FR) units of the gastrocnemius muscle. J Comp Neurol 184, 755-767.
25. Kerschensteiner D, Monje F & Stocker M (2003). Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory α-subunit Kv9.3. J Biol Chem 278, 18154-18161.
26. Kiehn O & Eken T (1998). Functional role of plateau potentials in vertebrate motor neurons. Curr Opin Neurobiol 8, 746-752.
27. Kiehn O, Kjaerulff O, Tresch MC & Harris-Warrick RM (2000). Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord. Brain Res Bull 53, 649-659.
28. + channels in layer 5 neocortical pyramidal neurones from young rats, subtypes and gradients. J Physiol 525, 621-639.
29. Li W, Ochalski PA, Brimijoin S, Jordan LM & Nagy JI (1995). C-terminals on motoneurons, electron microscope localization of cholinergic markers in adult rats and antibody-induced depletion in neonates. Neuroscience 65, 879-891.
30. + channel in hippocampal neurons. Neuron 25, 385-397.
31. McLarnon JG (1995). Potassium currents in motoneurones. Prog Neurobiol 47, 513-531.
32. Marrion NV (1997). Control of M-current. Annu Rev Physiol 59, 483-504.
33. Muennich EAL, Ream LJ, Dewey DE & Fyffe REW (2002). Clustering of Kv2.1 potassium channels in spinal neurons. Program number 850.7, 2002 Abstract Viewer and Itinerary Planner. Society of Neuroscience, Washington, DC. http://sfn.scholarone.com
34. + channel alters voltage-dependent activation. Mol Pharmacol 52, 821-828.
35. + current in rat hippocampal neurons. J Neurosci 19, 1728-1735.
36. Nagy JI, Yamamoto T & Jordan LM (1993). Evidence for the cholinergic nature of C-terminals associated with subsurface cisterns in alpha-motoneurons of rat. Synapse 15, 17-32.
37. Powers RK & Binder MD (2001). Input-output functions of mammalian motoneurons. Rev Physiol Biochem Pharmacol 143, 137-263.
38. Rekling JC, Funk GD, Bayliss DA, Dong XW & Feldman JL (2000). Synaptic control of motoneuronal excitability. Physiol Rev 80, 767-852.
39. Ribera AB (1999). Potassium currents in developing neurons. Ann N Y Acad Sci 868, 399-405.
40. Rose PK & Neuber-Hess M (1991). Morphology and frequency of axon terminals on the somata, proximal dendrites, and distal dendrites of dorsal neck motoneurons in the cat. J Comp Neurol 307, 259-280.
41. + channels and their functions in small dorsal root ganglion neurones of rat. J Physiol 493, 393-408.
42. + channel. J Cell Biol 135, 1619-1632.
43. Selyanko AA, Hadley JK & Brown DA (2001). Properties of single M-type KCNQ2/KCNQ3 potassium channels expressed in mammalian cells. J Physiol 534, 15-24.
44. Selyanko AA, Hadley JK, Wood IC, Abogadie FC, Jentsch TJ & Brown DA (2000). Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. J Physiol 522, 349-355.
45. 2+ channels by using knockout mice. Proc Natl Acad Sci U S A 96, 10899-10904.
46. Skinner JC, Alvarez FJ & Fyffe REW (1999). C-terminals are associated with postsynaptic muscarinic (M2) acetylcholine receptors in rat spinal cord alpha motoneurons. Abstr Soc Neurosci 25, 1917.
47. Starr KA & Wolpaw JR (1994). Synaptic terminal coverage of primate triceps surae motoneurons. J Comp Neurol 345, 345-358.
48. + channels and their distribution in large cortical pyramidal neurones. J Physiol 525, 565-566.
49. Svirskis G & Hounsgaard J (1998). Transmitter regulation of plateau properties in turtle motoneurons. J Neurophysiol 79, 45-50.
50. Takahashi T (1990). Membrane currents in visually identified motoneurones of neonatal rat spinal cord. J Physiol 423, 27-46.
51. Tiran Z, Peretz A, Attali B & Elson A (2003). Phosphorylation-dependent regulation of Kv2.1 channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon. J Biol Chem 278, 17509-17514.
52. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE & McKinnon D (1998). KCNQ2 and KCNQ3 potassium channel subunits, molecular correlates of the M-channel. Science 282, 1890-1893.
53. Welton J, Stewart W, Kerr R & Maxwell DJ (1999). Differential expression of the muscarinic m2 acetylcholine receptor by small and large motoneurons of the rat spinal cord. Brain Res 817, 215-219.
54. Wetts R & Vaughn JE (2001). Development of cholinergic terminals around rat spinal motor neurons and their potential relationship to developmental cell death. J Comp Neurol 435, 171-183.
55. Zhou H, Das S & Murthy KS (2003). Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors. Am J Physiol Gastrointest Liver Physiol 284, G472-G480.