Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 14, 2005, Pages 3434-3438

  Tran, Joseph A ^a   Pontillo, Joseph ^a   Arellano, Melissa ^a   Fleck, Beth A ^a   Tucci, Fabio C ^a   Marinkovic, Dragan ^a   Chen, Caroline W ^a   Saunders, John ^a   Foster, Alan C ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Antagonist; Cyclohexylpiperazine; Melanocortin 4 receptor

Indexed keywords

AMIDE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; PIPERIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; BINDING, COMPETITIVE; HUMANS; MOLECULAR CONFORMATION; PIPERIDINES; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20644466430     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.017     Document Type: Article

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