Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol)

Biomaterials

Volumn 17, Issue 12, 1996, Pages 1203-1218

  Bell, Cristi L ^a   Peppas, Nikolaos A ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Complexation; Drug delivery; Hydrogel bonding hydrogels; Hydrogels; Mesh size

Indexed keywords

COMPLEXATION; COPOLYMERS; DIFFUSION; GRAFTING (CHEMICAL); MECHANICAL TESTING; PH EFFECTS; PHYSIOLOGY; POLYETHYLENE GLYCOLS; POLYMERIC MEMBRANES; PROTEINS; SWELLING; WATER;

BOLTZMANN SUPERPOSITION MODEL; DECOMPLEXATION; POLYMETHACRYLIC ACID ETHYLENE GLYCOL; SOLUTE;

HYDROGELS;

COPOLYMER; MACROGOL; POLYACRYLIC ACID; PROTEIN; WATER;

ARTICLE; COMPLEX FORMATION; DIFFUSION; DIFFUSION COEFFICIENT; DISSOCIATION; HYDROGEL; MEMBRANE; MEMBRANE PERMEABILITY; PH; PRIORITY JOURNAL;

EID: 0030175577     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/0142-9612(96)84941-6     Document Type: Article

References (38)

1. Peppas NA. Hydrogels in Medicine and Pharmacy. Boca Raton: CRC Press, 1986.
2. Peppas NA. Physiologically responsive gels. J Bioact Compat Polym 1991; 6: 241-246.
3. Peppas NA, Barr-Howell BD. Characterization of the crosslinked structure of hydrogels. In: Peppas NA, ed. Hydrogels in Medicine and Pharmacy, Vol. 1. Boca Raton: CRC Press, 1986: 28-55.
4. Brannon-Peppas L. Preparation and characterization of crosslinked hydrophilic networks. In: Brannon-Peppas L, Harland RS, eds. Absorbent Polymer Technology. Amsterdam: Elsevier, 1990: 45-66.
5. Klier J, Scranton AB, Peppas NA. Self-associating networks of poly(methacrylic acid-g-ethylene glycol). Macromolecules 1990; 23: 4944-4949.
6. Peppas NA, Klier J. Controlled release by using poly(methacrylic acid-g-ethylene glycol) hydrogels. J Controlled Rel 1991; 16: 203-214.
7. Kuhn W, Hagerty B, Katchalsky A, Eisenberg A. Reversible dilation and contraction by changing the state of ionization of high-polymer acid networks. Nature 1950; 165: 514-516.
8. Liu G, Guillet JE, Al-Takrity ETB, Jenkin AD, Walton DRM. Dimensions of polyelectrolytes using the 'spectroscopic ruler'. 2. Conformational changes of poly(methacrylic acid) chains with variation in pH. Macromolecules 1991; 24: 68-74.
9. Horsky J. Ionization and collapse of poly(methacrylic acid) chains in methanolic solutions of basic salts. Polym Commun 1987; 29: 110-111.
10. Katchalsky A. Rapid swelling and deswelling of reversible gels of polymeric acids by ionization. Experientia 1949; 5: 319-320.
11. Katchalsky A, Kunzle O, Kuhn W. Behaviour of polyvalent polymeric ions in solution. J Polym Sci 1950; 5: 283-300.
12. Katchalsky A. Solutions of polyelectrolytes and mechanochemical systems. J Polym Sci 1949; 4: 393-412.
13. Ohmine I, Tanaka T. Salt effects on the phase transition of ionic gels. J Chem Phys 1992; 77: 5725-5729.
14. Brannon-Peppas L, Peppas NA. Time-dependent response of ionic polymer networks to pH and ionic strength changes. Int J Pharm 1991; 70: 53-57.
15. Brannon-Peppas L, Peppas NA. Equilibrium swelling behaviour of pH-sensitive hydrogels. Chem Eng Sci 1991; 46: 715-722.
16. Brannon-Peppas L, Peppas NA. Equilibrium swelling behavior of dilute ionic hydrogels in electrolytic solutions. J Controlled Release 1991; 16: 319-330.
17. Brannon-Peppas L, Peppas NA. Solute and penetrant diffusion in swellable polymers. XI. The mechanisms of drug release from pH-sensitive swelling-controlled systems. J Controlled Release 1989; 8: 267-274.
18. Hariharan D, Peppas NA. Characterization, dynamic swelling behavior and solute transport in cationic networks in applications to the development of swelling-controlled release systems. Polymer 1996; 37: 149-161.
19. Bekturov E, Bimendina L. Interpolymer complexes. Adv Polym Sci 1981; 41: 99-147.
20. Osada Y. Conversion of chemical energy into mechanical energy by synthetic polymers (chemomechanical systems). Adv Polym Sci 1987; 82: 2-46.
21. Bailey FESr, Lundberg RI, Gallard RW. Some factors affecting the molecular association of poly(ethylene glycol) and poly(acrylic acid) in aqueous solution. J Polym Sci Part A 1964; 2: 845-851.
22. Antipina AD, Baranovskii W Yu, Papisov IM, Kabanov VA. Equilibrium pecularities in the complexing of polymeric acids with poly(ethylene glycols). Vysokomol Soyed 1972; A14: 914-949.
23. Osada Y, Sato M. Thermal equilibrium of the intermacromolecular complexes of polycarboxylic acids realized by cooperative hydrogen bonding. J Polym Sci Polym Lett Ed 1976; 14: 129-134.
24. Osada Y. Equilibrium study of polymer-polymer complexation of poly(methacrylic acid) and poly(acrylic acid) with complementary polymers through cooperative hydrogen bonding. J Polym Sci Polym Chem 1979; 17: 3485-3498.
25. Baranovsky V, Shenkov S, Rashkov I, Borisov G. Nonspecific interactions in polymer-polymer reactions 2. Complex formation between poly(methacrylic acid) and monosubstituted poly(ethylene glycols). Eur Polym J 1991; 27: 643-647.
26. Osada Y, Takeuchi Y. Water and protein permeation through polymeric membrane having mechanochemically expanding and contracting pores, function of chemical valve. J Polym Sci Polym Lett Ed 1981; 19: 303-308.
27. Drummond RK, Klier J, Alameda JA, Peppas NA. Preparation of poly(methacrylic acid-g-ethylene oxide) microspheres. Macromolecules 1989; 22: 3816-3818.
28. Colton CK, Smith KA, Merrill EW, Farrell PC. Permeability studies with cellulosic membranes. J Biomed Mater Res 1971; 5: 459-488.
29. Tanford C. Physical Chemistry of Macromolecules. New York: Wiley, 1961.
30. Feil H, Bae YH, Feijen J, Kim SW. Molecular separation by thermosensitive hydrogel membranes. J Membr Sci 1991; 64: 283-294.
31. Peppas NA, Merrill EW. Crosslinked poly(vinyl alcohol) hydrogels as swollen elastic networks. J Appl Polym Sci 1977; 21: 1763-1770.
32. Brandrup J, Immergut EH. Polymer Handbook. New York: Wiley, 1989.
33. Barton AFM. CRC Handbook of Polymer-Solvent Interaction Parameters. Boca Raton: CRC Press, 1990.
34. Aklonis JJ, MacKnight WJ. Introduction to Polymer Viscoelastidty. New York: Wiley, 1983.
35. Ritger PI, Peppas NA. A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders, or discs. J Controlled Rel 1987; 5: 23-36.
36. Merrill EW, Dennison KA, Sung C. Partitioning and diffusion of solutes in hydrogels of poly(ethylene oxide). Biomaterials 1993; 14: 1117-1126.
37. Funatsu M, Hiromi K, Imahori K, Murachi T, Narita K. Proteins, Structure and Function, Vol. 1. New York: Wiley, 1972.
38. Peppas NA, Reinhart CT. Solute diffusion in swollen membranes. Part I. A new theory. J Membr Sci 1983; 15: 275-287.