Measurement of benzene oxide in the blood of rats following administration of benzene

Carcinogenesis

Volumn 18, Issue 8, 1997, Pages 1637-1641

  Lindstrom, Andrew B ^a,b   Yeowell O'Connell, Karen ^a   Waidyanatha, Suramya ^a   Golding, Bernard T ^c   Tornero Velez, Rogelio ^a   Rappaport, Stephen M ^a  

^a IL   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; BENZENE DERIVATIVE; BENZENE EPOXIDE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD LEVEL; GAS CHROMATOGRAPHY; LIVER CELL; MALE; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; BENZENE; CYCLOHEXANES; ENZYME STABILITY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; RATS; RATS, INBRED F344; TIME FACTORS;

EID: 0031409114     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.8.1637     Document Type: Article

References (32)

1. International Agency for Research on Cancer (1982) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol 29: Some Industrial Chemicals and Dyestuffs. IARC, Lyon.
2. Huff, J.E., Haseman, J.K., DeMarini, D.M., Eustis, S., Maronpot, R.R., Peters, A.C, Persing, R.L., Chrisp, C.E. and Jacobs, A.C. (1989) Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. Environ. Hlth Perspect., 82, 125-163.
3. Sammett, D., Lee, E.W., Kocsis, J.J. and Snyder, R. (1979) Partial hepatectomy reduces both metabolism and toxicity of benzene. J. Toxicol. Environ. Hlth, 5, 785-792.
4. 3) benzene. Biochem. Pharmacol., 26, 293-300.
5. Kenyon, E.M., Kraichely, R.E., Hudson, K.T. and Medinsky, M.A. (1996) Differences in rates of benzene metabolism correlate with observed genotoxicity. Toxicol. Appl. Pharmacol., 136, 49-56.
6. Snyder, R., Witz, G. and Goldstein, B.D. (1993) The toxicology of benzene. Environ. Hlth Perspect., 100, 293-306.
7. Medinsky, M.A., Sabourin, P.J., Lucier, G., Birnbaum, L.S. and Henderson, R.F. (1989) A physiological model for simulation of benzene metabolism by rats and mice. Toxicol. Appl. Pharmacol., 99, 193-206.
8. Kalf, G.F. (1987) Recent advances in the metabolism and toxicity of benzene. CRC Crit. Rev. Toxicol., 18, 141-159.
9. Vogel, E. and Günther, H. (1967) Benzene oxide-oxepin valence tautomerism. Angew. Chem. Internat. Edn. Engl., 6, 385-476.
10. Jerina, D.M. and Daly, J.W. (1974) Arene oxides: a new aspect of drug metabolism. Science, 185, 573-582.
11. Witz, G., Zhang, Z. and Goldstein, B.D. (1996) Reactive ring-opened aldehyde metabolites in benzene hematotoxicity. Environ. Hlth Perspect., 104 (Suppl 6), 1195-1199.
12. Witz, G., Gad, S.C., Trice, R.R., Oshiro, Y., Piper, C.E. and Goldstein, B.D. (1990) Genetic toxicity of the benzene metabolite trans,transmuconaldehyde in mammalian and bacterial cells. Mutat. Res., 240, 295-306.
13. Bleasdale, C., Kennedy, G., McGregor, J.O., Nieschalk, J., Pearce, K., Watson, W.P. and Golding, B.T. (1996) Chemistry of muconaldehydes of possible relevance to the toxicology of benzene. Environ. Hlth Perspect., 104 (Suppl 6), 1201-1209.
14. Snyder, R. and Hedli, C.C. (1996) An overview of benzene metabolism. Environ. Hlth Perspect., 104 (Suppl 6), 1165-1171.
15. Norpoth, K., Stücker, W., Krewet, E. and Muller, G. (1988) Biomonitoring of benzene exposure by trace analyses of phenylguanine. Int. Arch. Occup. Environ. Hlth, 60, 163-168.
16. Norpoth, K.H., Muller, G., Schell, C. and Jorg E. (1996) Phenylguanine found in urine after benzene exposure. Environ. Hlth Perspect., 104 (Suppl 6), 1159-1163.
17. Melikian, A.A., Prahald, A.K. and Colman, S. (1992) Isolation and characterization of two benzene-derived hemoglobin adducts in vivo in rats. Cancer Epidemiol. Biomarkers Prevent, 1, 307-313.
18. Bechtold, W.E., Sun, J.D., Birnbaum, L.S., Yin, S.N., Li, G.L., Kasicki, S., Lucier, G. and Henderson, R.F. (1992) S-phenylcysteine formation in hemoglobin as a biological exposure index to benzene. Arch. Toxicol., 66, 303-309.
19. 6] benzene. Cancer Res., 54, 4907-4914.
20. Yeowell-O'Connell, K., McDonald, T.A. and Rappaport, S.M. (1996) Analysis of hemoglobin adducts of benzene oxide by gas chromatography-mass spectrometry. Anal. Biochem., 237, 49-55.
21. Bechtold, W.E., Willis, J.K., Sun, J.D., Griffith, W.C. and Reddy, T.V. (1992) Biological markers of exposure to benzene: S-phenylcysteine in albumin. Carcinogenesis, 13, 1217-1220.
22. Yeowell-O'Connell, K., Rothman, N., Smith, M.T., Hayes, R.B., Gui-Lin, L., Bechtold, W., Dosemeci, M., Zhang, L., Yin, S.Y. and Rappaport, S.M. (1996) Hemoglobin adducts of benzene oxide in workers exposed to high levels of benzene in China. 87th annual meeting of American Association for Cancer Research, April 20-24, 1996, Washington DC, Abstract no. 1710.
23. Smith, M.T., Yager, J.W., Steinmetz, K.L. and Eastmond, D.A. (1989) Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity. Environ. Hlth Perspect., 82, 23-29.
24. Pfeiffer, R.W. and Irons, R.D. (1983) Alteration of lymphocyte function by quinones through sulfhydryl-dependent disruption of microtubule assembly. Int. J. Immunopharmacol., 5, 463-470.
25. Rushmore, T., Kalf, G. and Snyder, R. (1983) Covalent binding of benzene and its metabolites to DNA in rabbit bone marrow mitochondria in vitro. Chem.-Biol. Interact., 49, 133-154.
26. Jowa, L., Witz, G., Snyder, R., Winkle, S. and Kalf, G.F. (1990) Synthesis and characterization of deoxyguanosine-benzoquinone adducts. J. Appl. Toxicol., 10, 47-54.
27. 32P-postlabeling. Carcinogenesis, 12, 1181-1186.
28. Schatz-Kombrust, E., Goldstein, B.D. and Witz, G. (1991) The binding of trans,trans-muconaldehyde to deoxyguanosine and calf thymus DNA. Toxicologist, 11, 253.
29. 6] benzene to rats. Carcinogenesis, 14, 1921-1925.
30. Busby, W.F., Wang, J., Stevens, E.K., Padykula, R.E., Aleksejczyk, R.A. and Berchtold, g.A. (1990) Lung tumorigenicity of benzene oxide, benzene dihydrodiols and benzene diolepoxides in the BLU:Ha newborn mouse assay. Carcinogenesis, 11, 1473-1478.
31. Gillard, J.R., Newlands, M.J., Bridson, J.N. and Burnell, D.J. (1991) Pi-Facial stereoselectivity in the Diels-Alder reactions of benzene oxides. Can. J. Chem., 69, 1337-1343.
32. Donaldson, H.H. (1924) The Rat: Data and Reference Tables for the Albino Rat (Mus norvegicus albinus) and the Norway Rat (Mus norvegicus). Henry H. Donaldson, Philadelphia, PA.