Assessment of urinary trans, trans-muconic acid as a biomarker of exposure to benzene;Avaliação do ácido trans, trans-mucônico urinário como biomarcador de exposição ao benzeno

Revista de Saude Publica

Volumn 37, Issue 6, 2003, Pages 780-785

  de Paula, Flávia Cristina S ^a,b   Silveira, Josiane Nicácio ^a   Gonçalves Junquera, Roberto ^a   Alvarez Leite, Edna Maria ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b NONE   (Brazil)

Author keywords

Benzene, analysis; Biological markers; Occupational exposure; Trans, trans muconic acid

Indexed keywords

ALCOHOL; BENZENE; BIOLOGICAL MARKER; CREATININE; MUCONIC ACID; TRANS TRANS MUCONIC ACID; UNCLASSIFIED DRUG;

ADULT; AGE; ALCOHOL CONSUMPTION; ARTICLE; BRAZIL; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INDUSTRIAL WORKER; KRUSKAL WALLIS TEST; MALE; METABOLITE; OCCUPATIONAL EXPOSURE; OIL INDUSTRY; QUANTITATIVE ANALYSIS; RANK SUM TEST; REFERENCE VALUE; STATISTICAL ANALYSIS; STATISTICAL PARAMETERS; URINALYSIS; URINE LEVEL;

EID: 0347899312     PISSN: 00348910     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0034-89102003000600014     Document Type: Article

References (16)

1. Alessio L, Berlin A, Toffoletto F, Ghezzi I. Reability of urinary creatinine as a parameter used to adjust of urinary biological indicators. Int Arch Occup Environ Health 1985;55:99-106.
2. Barbosa EM. Exposição ocupacional ao benzeno: o ácido trans, trans-macônico como indicador biológico de exposição na indústria de refino de petróleo. Rio de Janeiro: Petrobrás/Serviços de Recursos Humanos; 1999. p. 1-48.
3. Boogaard PJ, Van Sitter NJ. Biological monitoring of exposure benzene: a comparison between S-phenylmercapturic acid, trans, trans-muconic acid and phenol. Occup Environ Med 1995;52:611-20.
4. Buratti M, Fustinoni S, Colombi A. Fast liquid chromatography determination of urinary trans, trans-muconic acid. J Chromatogr B 1996;677:257-63.
5. Ducos P, Gaudin R, Robert A, Francin JM, Meire C. Improvement in HPLC analysis of urinary trans, trans-muconic acid, a promissing substitute for phenol in assessment of benzene exposure. Int Arch Occup Environ Health 1990;62:529-34.
6. Ducos P, Gaudin R, Bel J, Marie C, Francin JM, Robert A et al. Trans, trans- muconic acid, a reliable biological indicator for the detection of individual benzene exposure down to the ppm level. Int Arch Occup Environ Health 1992;64:309-13.
7. Freitas NBB, Arcuri ASA. Valor de referência tecnológico (VRT)- a nova abordagem do controle da concentração de benzeno nos ambientes de trabalho. Rev Bras Saúde Ocup 1998;24:71-85.
8. Ghittori S, Maestri L, Fiorentino M, Imbriam M. Evaluation of occupational exposure to benzene urinalysis. Int Arch Occup Environ Health 1995;67:195-200.
9. Gobba F, Rovesti S, Borella P, Vivoli R, Caselgrandi E, Vivoli G. Inter-individual variability of benzene metabolism to trans, trans-muconic acid and its implications in the biological monitoring of ocupacional exposure. Sci Total Environ 1997;199:41-8.
10. Kivistö H, Pekari K, Peltonen K, Svinhufvud J, Veidebaum T, Sorsa M, et al. Biological monitoring of exposure to benzene in the production of benzene and in a cokery. Sci Total Environ 1997;199:49-63.
11. Lee BL, New AL, Kok PW, Ong HY, Shi CY, Ong CN. Urinary trans, trans-muconic acid determined by liquid chromatography: application in biological monitoring of benzene exposure. Clin Chem 1993;39:1788-92.
12. Minoia C, Sabbione E, Apostoli P, Pietra R, Pozzoli L, Gallorini M, et al. Trace element reference values in tissues from inhabitants of the european community I. A study of 46 elements in urine, blood and serum of italian subjects. Sci Total Environ 1990;95:89-105.
13. Ong CN, Kok PW, Lee BI, Shi CY, Ong HY, Chia KS et al. Evaluation of biomarkers for occupational exposure to benzene. Occup Environ Med 1995;52:528-33.
14. Paula FCS. Validação do ácido trans, trans-mucônico como biomarcador de exposição ao benzeno [dissertação]. Belo horizonte (MG): Universidade Federal de Minas Gerais; 2001.
15. Pezzagno G, Maestri L, Fiorentino ML. Trans, trans-muconic acid, a biological indicator to low levels of environmental benzene: some aspects of its specificity. Am J Ind Med 1999;35:511-8.
16. Scherer G, Renner T, Meger M. Analysis and evaluation of trans, trans-muconic acid as a biomarker for benzene exposure. J Cromatogr B 1998;717:179-99.