Unbound and Acylated Structures of the MecR1 Extracellular Antibiotic-sensor Domain Provide Insights into the Signal-transduction System that Triggers Methicillin Resistance

Journal of Molecular Biology

Volumn 361, Issue 3, 2006, Pages 506-521

  Marrero, Aniebrys ^a   Mallorquí Fernández, Goretti ^a   Guevara, Tibisay ^a   García Castellanos, Raquel ^a   Gomis Rüth, F Xavier ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

bacterial antibiotic resistance; MecR1 protein; methicillin resistance; MRSA; penicillin binding protein; lactamase

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; METALLOPROTEINASE; METICILLIN; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN G; SERINE;

ACYLATION; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS LICHENIFORMIS; BACTERIAL STRAIN; BINDING AFFINITY; BIOSYNTHESIS; CATALYSIS; CHROMOSOME; CYTOSOL; ENZYME ACTIVATION; GENE STRUCTURE; GENETIC TRANSCRIPTION; HYDROLYSIS; KINETICS; MEMBRANE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PENICILLIN RESISTANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RESPIRATORY TRACT INFECTION; SEPTIC SHOCK; SEPTICEMIA; SIGNAL TRANSDUCTION; SKIN INFECTION; SOFT TISSUE INFECTION; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION REGULATION;

BACILLUS LICHENIFORMIS; BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 33746340897     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.06.046     Document Type: Article

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