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Volumn 45, Issue 14, 2006, Pages 2209-2212

Expanding the utility of one-pot multistep reaction networks through compartmentation and recovery of the catalyst

Author keywords

Acidity; Heterogeneous catalysis; Magnetic properties; Nanostructures; Synthetic methods

Indexed keywords

NANOPARTICLE-BOUND BASE; NON-COMPLEMENTARY CATALYSTS; ONE-POT MULTISTEP REACTION NETWORKS; SYNTHETIC METHODS;

EID: 33746286331     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200503445     Document Type: Article
Times cited : (186)

References (65)
  • 8
    • 2942523508 scopus 로고    scopus 로고
    • Simplified workup of the reaction and purification of the product in sequences of reactions can be achieved by following the example of Ley and co-workers, who have used a variety of polymer-supported catalysts, reagents, and scavengers in complex reaction sequences. For example, see: a) I. R. Baxendale, S. V. Ley, C. Piutti, Angew. Chem. 2002, 114, 2298;
    • (2002) Angew. Chem. , vol.114 , pp. 2298
    • Baxendale, I.R.1    Ley, S.V.2    Piutti, C.3
  • 33
    • 0034614059 scopus 로고    scopus 로고
    • Using solid catalysts, a catalyst mixture may be recovered although its separation into pure components is generally not possible using published methodologies. a) F. Gelman, J. Blum, D. Avnir, J. Am. Chem. Soc. 2000, 122, 11 999;
    • (2000) J. Am. Chem. Soc. , vol.122 , pp. 11999
    • Gelman, F.1    Blum, J.2    Avnir, D.3
  • 42
    • 33746290066 scopus 로고    scopus 로고
    • note
    • As noted in reference [3], Ley and co-workers have demonstrated that complex, multistep organic syntheses can be carried out with simplified workup procedures by using polymer supported reagents, catalysts, and scavengers. However, the recovery and reuse of pure catalysts from a mixture of catalysts used in a multistep, one-pot reaction has not been demonstrated.
  • 43
    • 0000331942 scopus 로고    scopus 로고
    • Magnetic catalysts have been reported for a number of years. For example, see: a) W. Teunissen, A. A. Bol, J. W. Geus, Catal. Today 1999, 48, 329;
    • (1999) Catal. Today , vol.48 , pp. 329
    • Teunissen, W.1    Bol, A.A.2    Geus, J.W.3
  • 53
    • 33746292859 scopus 로고    scopus 로고
    • note
    • Gravimetric separation implies the recovery of solid catalysts from liquid media by means of filtration or settling.
  • 55
    • 0000893035 scopus 로고
    • Membranes have been effectively used for enzyme manipulation, and membrane reactors currently represent the state-of-the-art in the commercial practice of biocatalytic reactions. For an early example, see: a) M. D. Bednarski, H. K. Chenault, E. S. Simon, G. M. Whitesides, J. Am. Chem. Soc. 1987, 109, 1283;
    • (1987) J. Am. Chem. Soc. , vol.109 , pp. 1283
    • Bednarski, M.D.1    Chenault, H.K.2    Simon, E.S.3    Whitesides, G.M.4
  • 60
    • 33746306931 scopus 로고    scopus 로고
    • note
    • The data in Figure 2 for the first and second runs for the conversion of 1→2→3 match each other quite well, except for what appears to be a slight incubation period in the conversion of 2 into 3 in the first run. As this reaction was run in a two-step, one-pot sequence, there is some delay in the conversion of 2 into 3 because the former is formed in situ. In contrast, the second set of data for the conversion of 2 into 3 come from the one-pot reaction of 2→3→4. In this case, 2 is present at the outset and there is therefore no delay in its conversion. The second set of data for the conversion of 1 into 2 come from the single reaction 1→2 using the acid resin catalyst recovered from the one-pot reaction of 1→2→3.
  • 61
    • 33746318260 scopus 로고    scopus 로고
    • note
    • No kinetic data were collected for the conversion of 1 into 5a and 5b or into 6a and 6b. Consequently, no reliable TOF values were obtained.
  • 64
    • 0030826127 scopus 로고    scopus 로고
    • For production purposes, high-throughput approaches to multistep catalytic reactions based on a) membranes or b) fixed beds are also promising: a) B. B. Lakshmi, C. R. Martin, Nature 1997, 388, 758;
    • (1997) Nature , vol.388 , pp. 758
    • Lakshmi, B.B.1    Martin, C.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.