Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases

Angewandte Chemie - International Edition

Volumn 45, Issue 23, 2006, Pages 3772-3775

  Hu, Xiaoyi ^a   Addlagatta, Anthony ^b   Matthews, Brian W ^b   Liu, Jun O ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

Cellular effects; Drug design; Enzymes; Inhibitors; Structure elucidation

Indexed keywords

AMINO ACIDS; CELLS; COMPLEXATION; CRYSTAL STRUCTURE; ENDOCRINOLOGY; METHANE;

CELLULAR EFFECTS; DRUG DESIGN; INHIBITORS; METHIONINE AMINOPEPTIDASES; STRUCTURE ELUCIDATION;

ENZYME INHIBITION;

AMINOPEPTIDASE; GLYCOPROTEIN; METAP1 PROTEIN, HUMAN; METAP2 PROTEIN, HUMAN; PYRIMIDINE; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; CATTLE; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; HELA CELL; HUMAN; IC 50;

AMINOPEPTIDASES; ANIMALS; CATTLE; CELL PROLIFERATION; ENDOTHELIAL CELLS; GLYCOPROTEINS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; PYRIMIDINES;

EID: 33746265863     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200600757     Document Type: Article

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