5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: Increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals

Pharmacogenetics and Genomics

Volumn 16, Issue 8, 2006, Pages 601-607

  Verheggen, Raphaela ^a   Werner, Inga ^a   Lücker, Anne ^b   Brüss, Michael ^b   Göthert, Manfred ^b   Kaumann, Alberto J ^c  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

5 HT1B receptor wild type; 5 HT2A receptor; 5 hydroxytryptamine; Human temporal artery; Phe124Cys 5 HT1B receptor variant; SB224289; Sumatriptan; Vasoconstriction

Indexed keywords

2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; CYSTEINE; PHENYLALANINE; SEROTONIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN AGONIST; SODIUM PROTON EXCHANGE PROTEIN 1; SUMATRIPTAN;

ADULT; AGED; ALLELE; ARTERY CONSTRICTION; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CODON; CONTROLLED STUDY; DRUG POTENCY; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN CELL; MALE; MUTAGENESIS; NEUROSURGERY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION SITE; TEMPORAL ARTERY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENOTYPE; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; MUSCLE CONTRACTION; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN; SUMATRIPTAN; TEMPORAL ARTERIES; VARIATION (GENETICS);

EID: 33746255668     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/01.fpc.0000220564.52348.63     Document Type: Article

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