Inhibitory effect of chroman carboxamide on interleukin-6 expression in response to lipopolysaccharide by preventing nuclear factor-κB activation in macrophages

European Journal of Pharmacology

Volumn 543, Issue 1-3, 2006, Pages 158-165

  Hak Kim, Byung ^a   Lee, Kum Ho ^a   Chung, Eun Yong ^a   Chang, Yoon Sook ^a   Lee, Heesoon ^a   Lee, Chong Kil ^a   Min, Kyung Rak ^a   Kim, Youngsoo ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Chroman carboxamide; Inflammatory cytokine; Interleukin 6; Lipopolysaccharide; Macrophage; Nuclear factor B

Indexed keywords

6 HYDROXY 7 METHOXYCHROMAN 2 CARBOXYLIC ACID (3 NITROPHENYL)AMIDE; CHROMAN DERIVATIVE; CP 1158; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; EXPRESSION VECTOR; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CELL LINE; CHEMOKINE CCL4; CHEMOKINE CXCL10; CHEMOKINES, CXC; CHROMANS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENETIC VECTORS; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGE INFLAMMATORY PROTEINS; MACROPHAGES; MICE; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NITRO COMPOUNDS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33746214586     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.05.042     Document Type: Article

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