Distinct thresholds for CD8 T cell activation lead to functional heterogeneity: CD8 T cell priming can occur independently of cell division

Journal of Immunology

Volumn 170, Issue 5, 2003, Pages 2442-2448

  Auphan Anezin, Nathalie ^b   Verdeil, Grégory ^a   Schmitt Verhulst, Anne Marie ^a  

^a CNRS   (France)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL HETEROGENEITY; CONTROLLED STUDY; CYTOLYSIS; INTERFERON PRODUCTION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0345505645     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.5.2442     Document Type: Article

References (32)

1. Kaech, S. M., E. J. Wherry, and R. Ahmed. 2002. Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. Immunol. 2:251.
2. + T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:415.
3. van Stipdonk, M. J., E. E. Lemmens, and S. P. Schoenberger. 2001. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2:423.
4. Wong, P., and E. G. Pamer. 2001. Cutting edge: antigen-independent CD8 T cell proliferation. J. Immunol. 166:5864.
5. + T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192:63.
6. Lieberman, J., P. Shankar, N. Manjunath, and J. Andersson. 2001. Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood 98:1667.
7. Lee, P. P., C. Yee, P. A. Savage, L. Fong, D. Brockstedt, J. S. Weber, D. Johnson, S. Swetter, J. Thompson, P. D. Greenberg, et al. 1999. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 5:677.
8. + T cell responses in neonatal mice: susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells. J. Exp. Med. 193:595.
9. Zajac, A. J., J. N. Blattman, K. Murali-Krishna, D. J. Sourdive, M. Suresh, J. D. Altman, and R. Ahmed. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:2205.
10. Bevan, M. J., and P. J. Fink. 2001. The CD8 response on autopilot. Nat. Immunol. 2:381.
11. Auphan, N., S. Ghosh, R. A. Flavell, and A.-M. Schmitt-Verhulst. 1999. Differential requirements for NF-κB and AP-1 transactivation in response to minimal TCR engagement by a partial agonist in naive CD8 T cells. J. Immunol. 163: 5219.
12. Brossart, P., and M. J. Bevan. 1996. Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide. J. Exp. Med. 183:2449.
13. + T cells by a self-derived peptide. Nature 378:295.
14. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
15. MacDonald, H. R., and R. K. Lees. 1980. Dissociation of differentiation and proliferation in the primary induction of cytolytic T lymphocytes by alloantigens. J. Immunol. 124:1308.
16. Opferman, J. T., B. T. Ober, and P. G. Ashton-Rickardt. 1999. Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science 283:1745.
17. + T cells. J. Immunol. 168:1723.
18. Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
19. Auphan, N., J. Curnow, A. Guimezanes, C. Langlet, B. Malissen, A. Mellor, and A.-M. Schmitt-Verhulst. 1994. The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the TCR and influences negative selection in TCR-transgenic mice. Eur. J. Immunol. 24:1572.
20. Buferne, M., F. Luton, F. Letourneur, A. Hoeveler, D. Couez, M. Barad, B. Malissen, A.-M. Schmitt-Verhulst, and C. Boyer. 1992. Role of CD38 in surface expression of the T cell antigen receptor/CD3 complex and in activation for killing analyzed with CD3δ negative cytolytic T lymphocyte variant. J. Immunol. 148:657.
21. Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131.
22. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195.
23. Albert, F., M. Buferne, C. Boyer, and A. M. Schmitt-Verhulst. 1982. Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis. Immunogenetics 16:533.
24. Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1.
25. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917.
26. Kessler, B., D. Hudrisier, M. Schroeter, J. Tschopp, J. C. Cerottini, and I. F. Luescher. 1998. Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production. J. Immunol. 161:6939.
27. Madrenas, J., and R. N. Germain. 1996. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin. Immunol. 8:83.
28. Ben-Sasson, S. Z., R. Gerstel, J. Hu-Li, and W. E. Paul. 2001. Cell division is not a "clock" measuring acquisition of competence to produce IFN-γ or IL-4. J. Immunol. 166:112.
29. + T cell proliferation and effector function in vivo. Immunity 13:291.
30. Rosette, C., G. Werlen, M. A. Daniels, P. O. Holman, S. M. Alam, P. J. Travers, N. R. Gascoigne, E. Palmer, and S. C. Jameson. 2001. The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity 15:59.
31. Murphy, L. O., S. Smith, R. H. Chen, D. C. Fingar, and J. Blenis. 2002. Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4:556.
32. Verdeil, G., D. Puthier, C. Nguyen, A. M. Schmitt-Verhulst, and N. Auphan-Anezin. 2002. Gene profiling approach to establish the molecular bases for partial versus full activation of naive CD8 T lymphocytes. Ann. NY Acad. Sci. 975:68.