메뉴 건너뛰기




Volumn 11, Issue 3, 2006, Pages 176-183

Treatment of chronic myeloid leukemia with imatinib mesylate

Author keywords

Allogeneic stem cell transplantation; BCR ABL; Chronic myeloid leukemia; Imatinib mesylate; Tyrosine kinase inhibitor

Indexed keywords

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; BUSULFAN; CYTARABINE; DASATINIB; HYDROXYUREA; IMATINIB; NILOTINIB; NS 187; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; UNCLASSIFIED DRUG;

EID: 33746131219     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-006-0582-5     Document Type: Review
Times cited : (26)

References (58)
  • 1
    • 0000286732 scopus 로고
    • A minute chromosome in human granulocytic leukemia
    • PC Nowell DA Hungerford 1960 A minute chromosome in human granulocytic leukemia Science 132 1497 1497
    • (1960) Science , vol.132 , pp. 1497-1497
    • Nowell, P.C.1    Hungerford, D.A.2
  • 2
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining
    • JD Rowley 1973 A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining Nature 243 290 293
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 3
    • 0033565561 scopus 로고    scopus 로고
    • The biology of chronic myeloid leukemia
    • S Faderl M Talpaz Z Estrov 1999 The biology of chronic myeloid leukemia N Engl J Med 341 164 172
    • (1999) N Engl J Med , vol.341 , pp. 164-172
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3
  • 4
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • CL Sawyers 1999 Chronic myeloid leukemia N Engl J Med 340 1330 1340
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 5
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • MW Deininger JM Goldman JV Melo 2000 The molecular biology of chronic myeloid leukemia Blood 96 3343 3356
    • (2000) Blood , vol.96 , pp. 3343-3356
    • Deininger, M.W.1    Goldman, J.M.2    Melo, J.V.3
  • 6
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210 bcr/abl gene of the Philadelphia chromosome
    • GQ Daley RA Van Etten D Baltimore 1990 Induction of chronic myelogenous leukemia in mice by the P210 bcr/abl gene of the Philadelphia chromosome Science 247 824 830
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 7
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • TG Lugo AM Pendergast AJ Muller 1990 Tyrosine kinase activity and transformation potency of bcr-abl oncogene products Science 247 1079 1082
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3
  • 8
    • 3242808935 scopus 로고    scopus 로고
    • Natural history and staging of chronic myelogenous leukemia
    • J Cortes 2004 Natural history and staging of chronic myelogenous leukemia Hematol Oncol Clin North Am 18 569 584
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 569-584
    • Cortes, J.1
  • 9
    • 0038299199 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: A review and update of therapeutic strategies
    • G Garcia-Manero S Fader S O'Brien 2003 Chronic myelogenous leukemia: a review and update of therapeutic strategies Cancer 98 427 456
    • (2003) Cancer , vol.98 , pp. 427-456
    • Garcia-Manero, G.1    Fader, S.2    O'Brien, S.3
  • 10
    • 21744462480 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: A model for oncology
    • R Hehlmann U Berger A Hochhaus 2005 Chronic myeloid leukemia: a model for oncology Ann Hematol 84 487 497
    • (2005) Ann Hematol , vol.84 , pp. 487-497
    • Hehlmann, R.1    Berger, U.2    Hochhaus, A.3
  • 11
    • 0038483374 scopus 로고    scopus 로고
    • Randomized comparison of interferon α and hydroxyurea with hydroxyurea monotherapy in chronic myeloid leukemia (CML-Study II): Prolongation of survival by the combination of interferon α and hydroxyurea
    • R Hehlmann U Berger M Pfirrmann 2003 Randomized comparison of interferon α and hydroxyurea with hydroxyurea monotherapy in chronic myeloid leukemia (CML-Study II): prolongation of survival by the combination of interferon α and hydroxyurea Leukemia 17 1529 1537
    • (2003) Leukemia , vol.17 , pp. 1529-1537
    • Hehlmann, R.1    Berger, U.2    Pfirrmann, M.3
  • 12
    • 0028813711 scopus 로고
    • Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-α therapy
    • HM Kantarjian T Smith S O'Brien 1995 Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-α therapy Ann Intern Med 122 254 261
    • (1995) Ann Intern Med , vol.122 , pp. 254-261
    • Kantarjian, H.M.1    Smith, T.2    O'Brien, S.3
  • 13
    • 0029154919 scopus 로고
    • A randomized trial comparing interferon-α with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase
    • K Ohnishi R Ohno M Tomonaga 1995 A randomized trial comparing interferon-α with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase Blood 86 906 916
    • (1995) Blood , vol.86 , pp. 906-916
    • Ohnishi, K.1    Ohno, R.2    Tomonaga, M.3
  • 14
    • 17544386753 scopus 로고    scopus 로고
    • Multicenter prospective study of interferon-alpha and conventional chemotherapy versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia
    • K Ohnishi S Minami T Ueda 2000 Multicenter prospective study of interferon-alpha and conventional chemotherapy versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia Int J Hematol 72 229 236
    • (2000) Int J Hematol , vol.72 , pp. 229-236
    • Ohnishi, K.1    Minami, S.2    Ueda, T.3
  • 15
    • 6844259874 scopus 로고    scopus 로고
    • Survival with bone marrow transplantation versus hydroxyurea or interferon for chronic myelogenous leukemia
    • RP Gale R Hehlmann M-J Zhang 1998 Survival with bone marrow transplantation versus hydroxyurea or interferon for chronic myelogenous leukemia Blood 91 1810 1819
    • (1998) Blood , vol.91 , pp. 1810-1819
    • Gale, R.P.1    Hehlmann, R.2    Zhang, M.-J.3
  • 16
    • 0008947293 scopus 로고    scopus 로고
    • Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia
    • JA Hansen TA Gooley PJ Martin 1998 Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia N Engl J Med 338 962 968
    • (1998) N Engl J Med , vol.338 , pp. 962-968
    • Hansen, J.A.1    Gooley, T.A.2    Martin, P.J.3
  • 17
    • 0036786302 scopus 로고    scopus 로고
    • Current trends in hematopoietic stem cell transplantation in Europe
    • ME Gorre M Mohammed K Ellwood 2002 Current trends in hematopoietic stem cell transplantation in Europe Blood 100 2374 2386
    • (2002) Blood , vol.100 , pp. 2374-2386
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 18
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • BJ Druker S Tamura E Buchdunger 1996 Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nat Med 2 561 566
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 19
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • M Deininger E Buchdunger BJ Druker 2005 The development of imatinib as a therapeutic agent for chronic myeloid leukemia Blood 105 2640 2653
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 20
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • BJ Druker M Talpaz DJ Resta 2001 Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia N Engl J Med 344 1031 1037
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 21
    • 1542608328 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients
    • B Peng M Hayes D Resta 2004 Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients J Clin Oncol 22 935 942
    • (2004) J Clin Oncol , vol.22 , pp. 935-942
    • Peng, B.1    Hayes, M.2    Resta, D.3
  • 22
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • BJ Druker CL Sawyers H Kantarjian 2001 Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome N Engl J Med 344 1038 1042
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 23
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • H Kantarjian C Sawyers A Hochhaus 2002 Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia N Engl J Med 346 645 652
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 24
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a Phase 2 study
    • M Talpaz RT Silver BJ Druker 2002 Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a Phase 2 study Blood 99 1928 1937
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 25
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a Phase II study
    • CL Sawyers A Hochhaus E Feldman 2002 Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a Phase II study Blood 99 3530 3539
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 26
    • 0037105560 scopus 로고    scopus 로고
    • A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
    • OG Ottmann BJ Druker CL Sawyers 2002 A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias Blood 100 1965 1971
    • (2002) Blood , vol.100 , pp. 1965-1971
    • Ottmann, O.G.1    Druker, B.J.2    Sawyers, C.L.3
  • 27
    • 9444289883 scopus 로고    scopus 로고
    • Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia
    • M Towatari M Yanada N Usui 2004 Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia Blood 104 3507 3512
    • (2004) Blood , vol.104 , pp. 3507-3512
    • Towatari, M.1    Yanada, M.2    Usui, N.3
  • 28
    • 33644845774 scopus 로고    scopus 로고
    • High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: A phase II study by the Japan Adult Leukemia Study Group
    • M Yanada J Takeuchi I Sugiura 2006 High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group J Clin Oncol 24 460 466
    • (2006) J Clin Oncol , vol.24 , pp. 460-466
    • Yanada, M.1    Takeuchi, J.2    Sugiura, I.3
  • 29
    • 20844463222 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate for patients in the first chronic phase of chronic myeloid leukemia: Results of a Japanese phase II clinical study
    • Y Morishima M Ogura M Nishimura 2004 Efficacy and safety of imatinib mesylate for patients in the first chronic phase of chronic myeloid leukemia: results of a Japanese phase II clinical study Int J Hematol 80 261 266
    • (2004) Int J Hematol , vol.80 , pp. 261-266
    • Morishima, Y.1    Ogura, M.2    Nishimura, M.3
  • 30
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • SG O'Brien F Guilhot RA Larson 2003 Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia N Engl J Med 348 994 1004
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 31
    • 0345696854 scopus 로고    scopus 로고
    • Interferon alpha-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia
    • F Guilhot C Chastang M Michallet 1997 Interferon alpha-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia N Engl J Med 337 223 229
    • (1997) N Engl J Med , vol.337 , pp. 223-229
    • Guilhot, F.1    Chastang, C.2    Michallet, M.3
  • 32
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alpha plus cytarabine in newly diagnosed chronic myeloid leukemia
    • TP Hughes J Kaeda S Branford 2003 Frequency of major molecular responses to imatinib or interferon alpha plus cytarabine in newly diagnosed chronic myeloid leukemia N Engl J Med 349 1423 1432
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 33
    • 0038205817 scopus 로고    scopus 로고
    • Quality of life in patients with newly diagnosed chronic phase chronic myeloid leukemia on imatinib versus interferon alpha plus low-dose cytarabine: Results from the IRIS Study
    • EA Hahn GA Glendenning MV Sorensen 2003 Quality of life in patients with newly diagnosed chronic phase chronic myeloid leukemia on imatinib versus interferon alpha plus low-dose cytarabine: results from the IRIS Study J Clin Oncol 21 2138 2146
    • (2003) J Clin Oncol , vol.21 , pp. 2138-2146
    • Hahn, E.A.1    Glendenning, G.A.2    Sorensen, M.V.3
  • 34
    • 33644538458 scopus 로고    scopus 로고
    • Beneficial effects of cytogenetic and molecular response on long-term outcome in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM): Update from the IRIS Study
    • Simonsson B on behalf of the IRIS (International Randomized IFN vs STI571) Study Group. (abstract 166)
    • Simonsson B on behalf of the IRIS (International Randomized IFN vs STI571) Study Group 2005 Beneficial effects of cytogenetic and molecular response on long-term outcome in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM): Update from the IRIS Study Blood 106 52a (abstract 166)
    • (2005) Blood , vol.106
  • 35
    • 10744225099 scopus 로고    scopus 로고
    • Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome positive chronic myelogenous leukemia in the chronic phase: Comparison with historic data
    • HM Kantarjian S O'Brien J Cortes 2003 Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome positive chronic myelogenous leukemia in the chronic phase: comparison with historic data Cancer 98 2636 2642
    • (2003) Cancer , vol.98 , pp. 2636-2642
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.3
  • 36
    • 79959308232 scopus 로고    scopus 로고
    • Chronic myeloid leukemia; Loss of response to imatinib: Mechanisms and management
    • (Am Soc Hematol Educ Program)
    • Shah NP (2005) Chronic myeloid leukemia; Loss of response to imatinib: mechanisms and management. Hematology (Am Soc Hematol Educ Program):183-187
    • (2005) Hematology , pp. 183-187
    • Shah, N.P.1
  • 37
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • ME Gorre M Mohammed K Ellwood 2001 Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification Science 293 876 880
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 38
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
    • N von Bubnoff F Schneller C Peschel J Duyster 2002 BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study Lancet 359 487 491
    • (2002) Lancet , vol.359 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3    Duyster, J.4
  • 39
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • S Branford Z Rudzki S Walsh 2002 High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance Blood 99 3472 3475
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 40
    • 0037045589 scopus 로고    scopus 로고
    • Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: A gene-expression study
    • WK Hofmann S de Vos D Elashoff 2002 Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study Lancet 359 481 486
    • (2002) Lancet , vol.359 , pp. 481-486
    • Hofmann, W.K.1    De Vos, S.2    Elashoff, D.3
  • 41
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • C Roche-Lestienne V Soenen-Cornu N Grardel-Duflos 2002 Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment Blood 100 1014 1018
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3
  • 42
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • NP Shah JM Nicoll B Nagar 2002 Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia Cancer Cell 2 117 125
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 43
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • A Hochhaus S Kreil AS Corbin 2002 Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy Leukemia 16 2190 2196
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 44
    • 0038375012 scopus 로고    scopus 로고
    • Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • AS Corbin PL Rosee EP Stoffregen 2003 Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib Blood 101 4611 4614
    • (2003) Blood , vol.101 , pp. 4611-4614
    • Corbin, A.S.1    Rosee, P.L.2    Stoffregen, E.P.3
  • 45
    • 0037438467 scopus 로고    scopus 로고
    • Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
    • HM Kantarjian M Talpaz S O'Brien 2003 Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia Blood 101 473 475
    • (2003) Blood , vol.101 , pp. 473-475
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3
  • 46
    • 10744231480 scopus 로고    scopus 로고
    • Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α
    • J Cortes F Giles S O'Brien 2003 Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-α Blood 102 83 86
    • (2003) Blood , vol.102 , pp. 83-86
    • Cortes, J.1    Giles, F.2    O'Brien, S.3
  • 47
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • NP Shah C Tran FY Lee 2004 Overriding imatinib resistance with a novel ABL kinase inhibitor Science 305 399 401
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 48
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • T O'Hare DK Walters EP Stoffregen 2005 In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants Cancer Res 65 4500 4505
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 49
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • E Weisberg PW Manley W Breitenstein 2005 Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl Cancer Cell 7 129 141
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 50
    • 28444479480 scopus 로고    scopus 로고
    • NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
    • S Kimura H Naito H Segawa 2005 NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia Blood 106 3948 3954
    • (2005) Blood , vol.106 , pp. 3948-3954
    • Kimura, S.1    Naito, H.2    Segawa, H.3
  • 51
    • 0141863481 scopus 로고    scopus 로고
    • Residual disease in chronic myeloid leukemia after induction of molecular remission
    • T Lange DW Niederwieser MW Deininger 2003 Residual disease in chronic myeloid leukemia after induction of molecular remission N Engl J Med 349 1483 1484
    • (2003) N Engl J Med , vol.349 , pp. 1483-1484
    • Lange, T.1    Niederwieser, D.W.2    Deininger, M.W.3
  • 52
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • J Cortes S O'Brien H Kantarjian 2004 Discontinuation of imatinib therapy after achieving a molecular response Blood 104 2204 2205
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 53
    • 0028946866 scopus 로고
    • Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: Results and implications in 346 patients
    • JP Radich G Gehly T Gooley 1995 Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients Blood 85 2632 2638
    • (1995) Blood , vol.85 , pp. 2632-2638
    • Radich, J.P.1    Gehly, G.2    Gooley, T.3
  • 54
    • 33644523280 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Management of early stage disease
    • (Am Soc Hematol Educ Program)
    • Deininger MWN (2005) Chronic myeloid leukemia: management of early stage disease. Hematology (Am Soc Hematol Educ Program):174-182
    • (2005) Hematology , pp. 174-182
    • Deininger, M.W.N.1
  • 55
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
    • JJ Molldrem PP Lee C Wang 2000 Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia Nat Med 6 1018 1023
    • (2000) Nat Med , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3
  • 56
    • 0037217978 scopus 로고    scopus 로고
    • Interferon alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia
    • A Burchert S Wolfl M Schmidt 2003 Interferon alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia Blood 101 259 264
    • (2003) Blood , vol.101 , pp. 259-264
    • Burchert, A.1    Wolfl, S.2    Schmidt, M.3
  • 57
    • 0036566202 scopus 로고    scopus 로고
    • Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies
    • OA Elisseeva Y Oka A Tsuboi 2002 Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies Blood 99 3272 3279
    • (2002) Blood , vol.99 , pp. 3272-3279
    • Elisseeva, O.A.1    Oka, Y.2    Tsuboi, A.3
  • 58
    • 0035313251 scopus 로고    scopus 로고
    • In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents
    • Y Kano M Akutsu S Tsunoda 2001 In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents Blood 97 1999 2007
    • (2001) Blood , vol.97 , pp. 1999-2007
    • Kano, Y.1    Akutsu, M.2    Tsunoda, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.