Microwave-assisted amination of aryltrifluoroborates

Letters in Organic Chemistry

Volumn 3, Issue 4, 2006, Pages 320-323

  Kabalka, George W ^a   Zhou, Li Li ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Aromatic amine; Aryltrifluoroborates; Coupling reaction; Microwave; Solvent free

Indexed keywords

EID: 33746123808     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017806776114513     Document Type: Article

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37. 2 (0.10 g, 0.50 mmol) and pyridine (0.050 mL, 0.62 mmol ) contained in a clean, dry, 25 mL round-bottomed flask. The mixture was stirred at room temperature to ensure efficient mixing. The flask was then fitted with a septum (punctured by an 18 gauge needle), placed in the microwave (Ethos MOD, Milestone) and irradiated at 45% power for 10 min. After cooling, ether (3 × 10 mL) was added and the slurry stirred at room temperature to ensure product removal from the surface. The mixture was vacuum filtered using a sintered glass funnel and the product purified by flash chromatography to yield 155 mg of N-(4-methylphenyl) aniline (85%).