메뉴 건너뛰기




Volumn 7, Issue 12, 2005, Pages 2409-2411

An efficient and simple aqueous N-heterocyclization of aniline derivatives: Microwave-assisted synthesis of N-aryl azacycloalkanes

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; CYCLOALKANE DERIVATIVE; HALIDE; POTASSIUM CARBONATE; SOLVENT; VOLATILE ORGANIC COMPOUND;

EID: 20544455909     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol050683t     Document Type: Article
Times cited : (121)

References (35)
  • 9
    • 0141948432 scopus 로고    scopus 로고
    • AstraZeneca Research Foundation India: Bangalore, India, free copy available on request from: azrefi@ astrazeneca.com
    • (a) Varma, R. S. Advances in Green Chemistry: Chemical Syntheses Using Microwave Irradiation; AstraZeneca Research Foundation India: Bangalore, India, 2002 (free copy available on request from: azrefi@ astrazeneca.com).
    • (2002) Advances in Green Chemistry: Chemical Syntheses Using Microwave Irradiation
    • Varma, R.S.1
  • 10
    • 0242308610 scopus 로고    scopus 로고
    • Organic Synthesis using Microwaves and Supported Reagents
    • Loupy, A., Ed.; Wiley-VCH: Weinheim
    • (b) Varma, R. S. Organic Synthesis using Microwaves and Supported Reagents. In Microwaves in Organic Synthesis: Loupy, A., Ed.; Wiley-VCH: Weinheim, 2002; pp 181-218.
    • (2002) Microwaves in Organic Synthesis , pp. 181-218
    • Varma, R.S.1
  • 14
    • 0003780442 scopus 로고
    • Drayton, C. J., Ed.; Pergamon Press: New York
    • (b) Craig, P. N. In Comprehensive Medicinal Chemistry; Drayton, C. J., Ed.; Pergamon Press: New York, 1991; Vol. 8.
    • (1991) Comprehensive Medicinal Chemistry , vol.8
    • Craig, P.N.1
  • 27
  • 31
  • 32
    • 20544475800 scopus 로고    scopus 로고
    • note
    • In a representative reaction, 1.0 mmol of aniline derivatives, 1.1 mmol of dihalides, and 1.1 mmol of potassium carbonate in 2 mL of distilled water were placed in a 10 mL crimp-sealed, thick-walled reaction tube equipped with a pressure sensor and a magnetic stirrer. The reaction tube was placed in the microwave cavity (CEM Discover Focused Microwave Synthesis System with a built-in infrared temperature sensor), operated at 120 ± 5°C, 80-100 W, and a pressure of 65-70 psi for 20 min. After completion of the reaction, the organic portion was extracted into ethyl acetate. Removal of the solvent under reduced pressure and flash column chromatography furnished the desired product.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.