p21Cip1/Waf1/Sdi1 protects against hyperoxia by maintaining expression of Bcl-XL

Free Radical Biology and Medicine

Volumn 41, Issue 4, 2006, Pages 601-609

  Staversky, Rhonda J ^a   Vitiello, Peter F ^b   Gehen, Sean C ^b   Helt, Christopher E ^b   Rahman, Arshad ^a   Keng, Peter C ^b   O'Reilly, Michael A ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Free radicals

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; DOXORUBICIN; P53 UP REGULATED MODULATOR OF APOPTOSIS PROTEIN; PROTEIN BAX; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; HUMAN; HUMAN CELL; HYPEROXIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BASE SEQUENCE; BCL-X PROTEIN; BLOTTING, WESTERN; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA PRIMERS; HUMANS; HYPEROXIA;

EID: 33746080381     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.04.029     Document Type: Article

References (38)

1. Cadenas E., and Davies K.J. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29 (2000) 222-230
2. Jenkinson S.G. Oxygen toxicity. New Horiz 1 (1993) 504-511
3. Meek D.W. The p53 response to DNA damage. DNA Repair (Amsterdam) 3 (2004) 1049-1056
4. Waldman T., Kinzler K.W., and Vogelstein B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55 (1995) 5187-5190
5. Harper J.W., Adami G.R., Wei N., Keyomarsi K., and Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75 (1993) 805-816
6. McGrath-Morrow S.A., Cho C., Soutiere S., Mitzner W., and Tuder R. The effect of neonatal hyperoxia on the lung of p21Waf1/Cip1/Sdi1-deficient mice. Am. J. Respir. Cell Mol. Biol. 30 (2004) 635-640
7. Helt C.E., Rancourt R.C., Staversky R.J., and O'Reilly M.A. p53-dependent induction of p21 Cip1/Waf1/Sdi1 protects against oxygen-induced toxicity. Toxicol. Sci. 63 (2001) 214-222
8. O'Reilly M.A., Staversky R.J., Watkins R.H., Reed C.K., de Mesy Jensen K.L., Finkelstein J.N., and Keng P.C. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am. J. Respir. Cell Mol. Biol. 24 (2001) 703-710
9. Javelaud D., and Besancon F. Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. J. Biol. Chem. 277 (2002) 37949-37954
10. Yu J., Wang Z., Kinzler K.W., Vogelstein B., and Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 100 (2003) 1931-1936
11. Seoane J., Le H.V., and Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419 (2002) 729-734
12. Yin Y., Solomon G., Deng C., and Barrett J.C. Differential regulation of p21 by p53 and Rb in cellular response to oxidative stress. Mol. Carcinog. 24 (1999) 15-24
13. Gorospe M., Cirielli C., Wang X., Seth P., Capogrossi M.C., and Holbrook N.J. p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene 14 (1997) 929-935
14. Budinger G.R., Tso M., McClintock D.S., Dean D.A., Sznajder J.I., and Chandel N.S. Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins. J. Biol. Chem. 277 (2002) 15654-15660
15. Wang X., Ryter S.W., Dai C., Tang Z.L., Watkins S.C., Yin X.M., Song R., and Choi A.M. Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. J. Biol. Chem. 278 (2003) 29184-29191
16. He C.H., Waxman A.B., Lee C.G., Link H., Rabach M.E., Ma B., Chen Q., Zhu Z., Zhong M., Nakayama K., Nakayama K.I., Homer R., and Elias J.A. Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J. Clin. Invest. 115 (2005) 1039-1048
17. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., and Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282 (1998) 1497-1501
18. O'Reilly M.A., Staversky R.J., Huyck H.L., Watkins R.H., LoMonaco M.B., D'Angio C.T., Baggs R.B., Maniscalco W.M., and Pryhuber G.S. Bcl-2 family gene expression during severe hyperoxia induced lung injury. Lab. Invest. 80 (2000) 1845-1854
19. Helt C.E., Staversky R.J., Lee Y.J., Bambara R.A., Keng P.C., and O'Reilly M.A. The CDK and PCNA domains on p21 Cip1 both function to inhibit G1/S progression during hyperoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 286 (2004) L506-L513
20. + bone marrow cells in essential thrombocythemia. Haematologica 89 (2004) 1199-1206
21. Schmidt T., Korner K., Karsunky H., Korsmeyer S., Muller R., and Moroy T. The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53. Cell Death Differ. 6 (1999) 873-882
22. Komarov P.G., Komarova E.A., Kondratov R.V., Christov-Tselkov K., Coon J.S., Chernov M.V., and Gudkov A.V. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285 (1999) 1733-1737
23. P.F. Vitiello, R.J. Staversky, S.C. Gehen, C.J. Johnston, J.N. Finkelstein, T.W. Wright, M.A. O'Reilly, P21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am. J. Pathol. (in press); 2006.
24. Cheng E.H., Wei M.C., Weiler S., Flavell R.A., Mak T.W., Lindsten T., and Korsmeyer S.J. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8 (2001) 705-711
25. Chang B.D., Watanabe K., Broude E.V., Fang J., Poole J.C., Kalinichenko T.V., and Roninson I.B. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc. Natl. Acad. Sci. USA 97 (2000) 4291-4296
26. Fritah A., Saucier C., Mester J., Redeuilh G., and Sabbah M. p21WAF1/CIP1 selectively controls the transcriptional activity of estrogen receptor {alpha}. Mol. Cell. Biol. 25 (2005) 2419-2430
27. Engel F.B., Hauck L., Boehm M., Nabel E.G., Dietz R., and von Harsdorf R. p21(CIP1) controls proliferating cell nuclear antigen level in adult cardiomyocytes. Mol. Cell. Biol. 23 (2003) 555-565
28. Allan L.A., Duhig T., Read M., and Fried M. The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21(WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene. Mol. Cell. Biol. 20 (2000) 1291-1298
29. Rancourt R.C., Keng P.C., Helt C.E., and O'Reilly M.A. The role of p21 Cip1/WAF1 in growth of epithelial cells exposed to hyperoxia. Am. J. Physiol. 280 24 Pt 4 (2001) L617-L626
30. Barazzone C., Horowitz S., Donati Y.R., Rodriguez I., and Piguet P.F. Oxygen toxicity in mouse lung: pathways to cell death. Am. J. Respir. Cell Mol. Biol. 19 (1998) 573-581
31. Hainaut P., and Milner J. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res. 53 (1993) 4469-4473
32. Chipuk J.E., Kuwana T., Bouchier-Hayes L., Droin N.M., Newmeyer D.D., Schuler M., and Green D.R. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 (2004) 1010-1014
33. Melino G., Bernassola F., Ranalli M., Yee K., Zong W.X., Corazzari M., Knight R.A., Green D.R., Thompson C., and Vousden K.H. p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J. Biol. Chem. 279 (2004) 8076-8083
34. Tian H., Wittmack E.K., and Jorgensen T.J. p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. Cancer Res. 60 (2000) 679-684
35. Zhang Y., Fujita N., and Tsuruo T. p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line. Int. J. Cancer 83 (1999) 790-797
36. Chandel N.S., Vander Heiden M.G., Thompson C.B., and Schumacker P.T. Redox regulation of p53 during hypoxia. Oncogene 19 (2000) 3840-3848
37. Hammond E.M., Denko N.C., Dorie M.J., Abraham R.T., and Giaccia A.J. Hypoxia links ATR and p53 through replication arrest. Mol. Cell. Biol. 22 (2002) 1834-1843
38. Helt C.E., Cliby W.A., Keng P.C., Bambara R.A., and O'Reilly M.A. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J. Biol. Chem. 280 (2005) 1186-1192