Accurate prediction of BRCA1 and BRCA2 heterozygous genotype using expression profiling after induced DNA damage

Clinical Cancer Research

Volumn 12, Issue 13, 2006, Pages 3896-3901

  Kote Jarai, Zsofia ^a   Matthews, Lucy ^a   Osorio, Ana ^a,b   Shanley, Susan ^a,c   Giddings, Ian ^a   Moreews, Francois ^a   Locke, Imogen ^a,c   Evans, D Gareth ^d   Eccles, Diana ^e   Williams, Richard D ^a   Girolami, Mark ^f   Campbell, Colin ^g   Eeles, Ros ^a,c  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d ST MARY S HOSPITAL   (United Kingdom)

^e PRINCESS ANNE HOSPITAL   (United Kingdom)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

^g UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; RNA;

ADULT; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; FEMALE; FIBROBLAST CULTURE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; NORMAL DISTRIBUTION; ONCOGENE; PRIORITY JOURNAL; RADIATION EXPOSURE; SKIN BIOPSY;

ADULT; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CLUSTER ANALYSIS; DNA DAMAGE; FEMALE; GENE EXPRESSION PROFILING; GENOTYPE; HETEROZYGOTE; HUMANS; MIDDLE AGED; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOFTWARE;

EID: 33746071182     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-2805     Document Type: Article

References (23)

1. Easton D, Peto J. The contribution of inherited predisposition to cancer incidence. Cancer Surv 1990;9:395-416.
2. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71.
3. Wooster R, Bignell G, Lancaster J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995;378:789-92.
4. Scully R, Livingston DM. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 2000;408:429-32.
5. Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002;108:171-82.
6. Marquis ST, Rajan JV, Wynshaw-Boris A, et al. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet 1995;11:17-26.
7. Scully R, Chen J, Plug A, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997;88:265-75.
8. Sharan SK, Morimatsu M, Albrecht U, et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997;386:804-10.
9. Kote-Jarai Z, Eeles RA. BRCA1, BRCA2 and their possible function in DNA damage response. Br J Cancer 1999;81:1099-102.
10. Monteiro ANA. BRCA1: exploring the links to transcription. Trends Biochem Sci 2000;10:469-74.
11. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A 2000;97:1020-5.
12. Wang Q, Zhang H, Kajino K, Greene MI. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 1998;17:1939-48.
13. Preobrazhenska O, Yakymovych M, Kanamoto T, et al. BRCA2 and Smad3 synergize in regulation of gene transcription. Oncogene 2002;21:5660-4.
14. Howlett NG, Taniguchi T, Olson S, et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002;297:606-9.
15. Perou CM, Jeffrey SS, van de RM, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A 1999;96:9212-7.
16. Hedenfalk I, Duggan D, Chen Y, et al. Gene-expression profiles in hereditary breast cancer. N Engl J Med 2001;344:539-48.
17. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
18. Kote-Jarai Z, Williams R, Cattini N, et al. Gene expression profiling after radiation induced DNA damage is highly predictive of BRCA1 mutation carrier status. Clin Cancer Res 2004;10:958-63.
19. Campbell C. Kernel methods: a survey of current techniques. Neurocomputing 2002;48:63-84.
20. Girolami M, Rogers S. Variational Bayesian multinomial probit regression with Gaussian process priors neural computation (MIT Press) 2006 In press.
21. Sturn A, Quackenbush J, Trajanoski Z. Genesis: cluster analysis of microarray data. Bioinformatics 2002;18:207-8.
22. Phelan CM, Dapic V, Tice B, et al. Classification of BRCA1 missense variants of unknown clinical significance. J Med Genet 2005;42:138-46.
23. Tavtigian SV, Deffenbaugh AM, Yin L, et al. Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral. J Med Genet 2006;43:295-305.