Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue

Biochemical Journal

Volumn 397, Issue 2, 2006, Pages 369-375

  Baird, Fiona E ^a   Pinilla Tenas, Jorge J ^a   Ogilvie, William L J ^a   Ganapathy, Vadival ^b   Hundal, Harinder S ^a   Taylor, Peter M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Allosteric regulation; Amino acid transport; Hydrogen ion; System A; System N

Indexed keywords

AMINES; CELL MEMBRANES; GENE TRANSFER; PH; SUBSTRATES;

ALLOSTERIC REGULATION; AMINO ACID TRANSPORT; HYDROGEN ION; SYSTEM A; SYSTEM N;

AMINO ACIDS;

AMINO ACID TRANSPORTER; DIETHYL PYROCARBONATE; HISTIDINE; HYDROXYLAMINE; POTASSIUM ION; PROTEIN SNAT2; PROTEIN SNAT5; PROTON; SODIUM ION; UNCLASSIFIED DRUG; SLC38A5 PROTEIN, HUMAN; SNAT2 PROTEIN, RAT;

ALLOSTERISM; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; NONHUMAN; OOCYTE; PH MEASUREMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; XENOPUS; ANIMAL; CELL MEMBRANE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PH; PHYSIOLOGY; RAT; XENOPUS LAEVIS;

MAMMALIA;

ALLOSTERIC SITE; AMINO ACID TRANSPORT SYSTEMS; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; CELL MEMBRANE; CONSERVED SEQUENCE; FEMALE; HISTIDINE; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; OOCYTES; PROTEIN TRANSPORT; RATS; XENOPUS LAEVIS;

EID: 33746044924     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060026     Document Type: Article

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