Anti-clastogenic effect of β-glucan extracted from barley towards chemically induced DNA damage in rodent cells

Human and Experimental Toxicology

Volumn 25, Issue 6, 2006, Pages 319-324

  Angeli, J P F ^a   Ribeiro, L R ^b   Bellini, M F ^b   Mantovani, M S ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

glucans; Anti mutagenesis; Chromosomal aberrations; Drug metabolizing cells

Indexed keywords

2 AMINOANTHRACENE; BETA GLUCAN; CYTARABINE; CYTARABINE TRIPHOSPHATE; DNA POLYMERASE; ENZYME INHIBITOR; MESYLIC ACID METHYL ESTER;

ANIMAL CELL; ARTICLE; BARLEY; CELL LINE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG METABOLISM; IN VITRO STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RODENT;

ANIMALS; ANTHRACENES; ANTIMETABOLITES, ANTINEOPLASTIC; ANTIMUTAGENIC AGENTS; BETA-GLUCANS; CELLS, CULTURED; CHO CELLS; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; CYTARABINE; DNA DAMAGE; HORDEUM; METHYL METHANESULFONATE; MUTAGENS;

ARA; HORDEUM VULGARE SUBSP. VULGARE; RODENTIA;

EID: 33746015912     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327106ht631oa     Document Type: Article

References (32)

1. Weisburger JH. Mechanism of action of antioxidant as exemplified in vegetables, tomatoes and tea. Food Chem Toxicol 1999; 37: 943-48.
2. Trichopoulou A, Vasilopoulou E. Mediterranean diet and longevity. Br J Nutr 2000; 84: 205-209.
3. Bloch A, Thomson CA. Position of the American Dietetic Association: phytochemicals and functional foods. J Am Diet Assoc 1995; 95: 493-96.
4. Halliwell B. Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept. Nutr Rev 1999; 57: 104-13.
5. Kelloff GF, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr 2000; 130: 467-71.
6. Ferrari CKB, Torres EAFS. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomed Pharmacother 2003; 57: 251-60.
7. Mizuno T, Morimoto M, Minato KI, Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem 1998; 62: 434-37.
8. Chihara G, Maeda Y, Hamuro J, Sasaki T, Fumiko F. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature 1969; 222: 687-96.
9. Tzianabos AO, Cisneros L. Prophylaxis with the immunomodulator PGG glucana enhances antibiotic efficacy in rats infected with antibiotic-resistant bacteria. Ann NY Acad Sci 1996; 797: 285-87.
10. Reynolds JA, Kastello MD, Harrigton DG, Crabs CL, Peters CJ, Jemski JV, et al. Glucan-induced enhancement of host resistance to selected infectious diseases. Infect Immun 1980; 30: 51-57.
11. Meira DA, Pereira PCM, Marcondes-Machado J, Mendes RP, Barraviera B, Pellegrino JRJ, et al. The use of glucan as immunostimulant in the treatment of paracoccidioidomycosis. Am J Trop Med Hyg 1996; 55: 496-503.
12. Holbrook TW, Cook JA, Parker BW. Immunization against Leishmania dovavani: glucana as an adjuvant with killed promastigotes. Am J Trop Med Hyg 1981; 30: 762-68.
13. Falch BH, Espevik T, Ryan L, Stokke BT. The cytokine stimulating activity of (1 → 3)-β-D-glucans is dependent on the triple helix conformation. Carbohydr Res 2000; 329: 587-96.
14. Hofer M, Pospisil M. Glucan as stimulator of hematopoiesis in normal and gamma-irradiated mice. A survey of the authors' results. Int J Immunopharmacol 1997; 19: 607-609.
15. Tsiapali E, Whaley S, Kalbfleisch J, Ensley HE, Browder IW, Willians LD. Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity. Free Rad Biol Med 2001; 30: 393-402.
16. 4 and neutrophil attractant activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan. J Clin Invest 1990; 86: 1556-64.
17. Chovartovicova D, Navarova D. Suppressing effects of glucan on micronuclei induced by cyclophosphamide in mice. Mutat Res 1995; 346: 43-48.
18. Chovarticova D, Kovacikova Z, Sandula J, Navarova J. Protective effects of sulfoethylglucan against hexavalent chromium. Mutat Res 1993; 302: 207-11.
19. Chorvatovicova D, Machova E, Sandula J. Ultrasonication: the way to achieve antimutagenic effects of carboxymethyl-chitin-glucan by oral administration. Mutat Res 1998; 412: 83-89.
20. Chorvaticova D, Sandula J. Effects of carboxymethylchitin-glucan on cyclophosphamide induced mutagenicity. Mutat Res 1995; 346: 43-48.
21. Bez GC, Jordão BQ, Vicentini VEP, Mantovani MS. Differential protection of A and B chlorophyll in MMC-mediated induction of chromatid and isochromatid breaks in human lymphocyte culture. Cytologia 2001; 66: 313-18.
22. Brusick DJ. Principles of genetic toxicology, second edition. Plenum Press, 1987.
23. Waters MD, Brady AL, Stack HF, Brockman HE. Antimutagenicity profiles for some model compounds. Mutat Res 1990; 238: 57-85.
24. Chen C, Kong ANT. Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 2005; 26: 318-26.
25. Kada T, Inoue T, Namiki N. Environmental desmutagens and antidesmutagens. In Klekowski EJ ed. Environmental mutagenesis and plant biology. Praeger, 1982.
26. Delaney B, Carlson T, Zheng G-H, Hess R, Knutson N, Fraser S, et al. Repeated dose oral toxicological evaluation of concentrated barley β-glucan in CD-1 mice including a recovery phase. Food Chem Toxicol 2003; 41: 1089-102.
27. Tohamy AA, El-Ghor AA, El-Nahas SM, Noshy MM. β-glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin. Mutat Res 2003; 541: 45-53.
28. Lazarova M, Labaj J, Kovacikova Z, Slamenova D. Diet containing fungal (1 → 3)-β-glucan derivative exhibits protective effects against DNA lesions induced in freshly isolated rat cells. Neoplasma 2004; 51: 431-35.
29. Hashimoto T, Nonaka Y, Minato K, Kawaki S, Mizuno M, Fukuda I, et al. Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of Cytochrome F450s in mice. Biosci Biotechnol Biochem 2002; 66: 1610-14.
30. Okamoto T, Kodoi R, Nonaka Y, Fukuda I, Hashimoto T, Kanazawa K, et al. Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver. Biofactors 2004; 21: 407-409.
31. Kufe DW, Major PP. Studies on the mechanism of action of cytosine arabinoside. Med Pediat Oncol 1982; 1: 49-67.
32. Fram RJ, Kufe DW. Inhibition of DNA excision repair and the repair of X-ray induced DNA damage by cytosine arabinoside and Hydroxyurea. Pharmacol Ther 1985; 31: 165-76.