Prophylaxis with the immunomodulator PGG glucan enhances antibiotic efficacy in rats infected with antibiotic-resistant bacteria

Annals of the New York Academy of Sciences

Volumn 797, Issue , 1996, Pages 285-287

  Tzianabos, Arthur O ^a   Cisneros, Ronald L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA GLUCAN; CEFALOTIN; CIPROFLOXACIN; GENTAMICIN; IMMUNOMODULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL INFECTION; CONFERENCE PAPER; DRUG EFFICACY; ESCHERICHIA COLI; NONHUMAN; RAT; SEPSIS; STAPHYLOCOCCUS AUREUS;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 0030475128     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb52980.x     Document Type: Conference Paper

References (4)

1. ONDERDONK, A. B., R. L. CISNEROS, P. L. HINKSON & G. R. OSTROFF. 1992. Anti-infective effect of poly-β1-6 glucotriosyl β1-3 glucopyranose (PGG) glucan in vivo. Infect. Immun. 60: 1642-1647.
2. BABINEAU, T. J., A. HACKFORD, A. KENLER, B. BISTRIAN, R. A. FORSE, P. G. FAIRCHILD, S. HEARD, M. KEROACK, P. CAUSHAJ & P. BENOTTI. 1994. A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-Glucan) in high-risk surgical patients. Arch. Surg. 129: 1204-1210.
3. CISNEROS, R. L., R. BAWDON & A. B. ONDERDONK. 1990. Efficacy of ampicillin/sulbactam for the treatment of experimental intra-abdominal sepsis. Curr. Ther. Res. 48: 1021-1209.
4. LOUIE, T. J., A. B. ONDERDONK, S. L. GORBACH & J. G. BARLETT. 1977. Therapy of experimental intraabdominal sepsis. A comparison of four cephalosporins with clindamycin and gentamicin. J. Infect. Dis. 135: 518-522.