Autologous full-thickness skin substitute for healing chronic wounds

British Journal of Dermatology

Volumn 155, Issue 2, 2006, Pages 267-274

  Gibbs, S ^a   Van Den Hoogenband, H M ^a   Kirtschig, G ^a   Richters, C D ^b   Spiekstra, S W ^a   Breetveld, M ^a   Scheper, R J ^a   De Boer, E M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Euro Skin Bank   (Netherlands)

Author keywords

Autologous; Inert ulcer; Skin substitute; Wound healing

Indexed keywords

ADULT; AGED; ARTICLE; AUTOGRAFT; CHRONIC WOUND; CLINICAL ARTICLE; DERMIS; DISEASE DURATION; EPIDERMIS; EPITHELIZATION; FEMALE; FIBROBLAST; FOLLOW UP; FULL THICKNESS SKIN GRAFT; GRANULATION TISSUE; HUMAN; HUMAN CELL; HUMAN TISSUE; LEG ULCER; MALE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PUNCH BIOPSY; SURGICAL TECHNIQUE; TISSUE ENGINEERING; VACUUM; WOUND CLOSURE; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; BASEMENT MEMBRANE; CHRONIC DISEASE; FEMALE; HUMANS; LEG ULCER; MALE; MIDDLE AGED; SKIN; SKIN TRANSPLANTATION; SKIN, ARTIFICIAL; TISSUE ENGINEERING; TREATMENT OUTCOME; WOUND HEALING;

EID: 33745930557     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07266.x     Document Type: Article

References (28)

1. Mekkes JR, Loots MA, van der Wal AC et al. Causes, investigation and treatment of leg ulceration. Br J Dermatol 2003; 148:388-401.
2. Bello YM, Falabella AP, Eaglstein WH. Tissue-engineered skin. Current status in wound healing. Am J Clin Dermatol 2001; 2:305-13.
3. Boyce ST, Warden GD. Principles and practices for treatment of cutaneous wounds with cultured skin substitutes. Am J Surg 2002; 183:445-56.
4. Eming SA, Smola H, Krieg T. Treatment of chronic wounds: state of the art and future concepts. Cells Tissues Organs 2002; 172:105-17.
5. Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. BMJ 2002; 324:160-3.
6. Jones I, Currie L, Martin R. A guide to biological skin substitutes. Br J Plast Surg 2002; 55:185-93.
7. Hanft JR, Surprenant MS. Healing of chronic foot ulcers in diabetic patients treated with a human fibroblast-derived dermis. J Foot Ankle Surg 2002; 41:291-9.
8. Caravaggi C, De Giglio R, Pritelli C et al. HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, multicenter, controlled, randomized clinical trial. Diabetes Care 2003; 26:2853-9.
9. Green H, Kehinde O, Thomas J. Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci USA 1979; 76:5665-8.
10. Limat A, French LE, Blal L et al. Organotypic cultures of autologous hair follicle keratinocytes for the treatment of recurrent leg ulcers. J Am Acad Dermatol 2003; 48:207-14.
11. Lobmann R, Pittasch D, Muhlen I et al. Autologous human keratinocytes cultured on membranes composed of benzyl ester of hyaluronic acid for grafting in nonhealing diabetic foot lesions: a pilot study. J Diabetes Complications 2003; 17:199-204.
12. Brem H, Balledux J, Bloom T et al. Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent: a new paradigm in wound healing. Arch Surg 2000; 135:627-34.
13. Ponec M, Hasper I, Vianden GD et al. Effects of glucocorticosteroids on primary human skin fibroblasls. II. Effects on total protein and collagen biosynthesis by confluent cell cultures. Arch Dermatol Res 1977; 259:125-34.
14. Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S et al. Induction of cytokine (interleukin-1 alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. Exp Dermatol 2005; 14:109-16.
15. El-Ghalbzouri A, Gibbs S, Lamme E et al. Effect of fibroblasts on epidermal regeneration. Br J Dermatol 2002; 147:230-43.
16. Gibbs S, Silva Pinto AN, Murli S et al. Epidermal growth factor and keratinocyte growth factor differentially regulate epidermal migration, growth, and differentiation. Wound Repair Regen 2000; 8:192-203.
17. El-Ghalbzouri A, Hensbergen P, Gibbs S et al. Fibroblasts facilitate re-epithelialization in wounded human skin equivalents. Lab Invest 2004; 84:102-12.
18. Chakrabarty KH, Dawson RA, Harris P et al. Development of autologous human dermal-epidermal composites based on sterilized human allodermis for clinical use. Br J Dermatol 1999; 141:811-23.
19. El-Ghalbzouri A, Lamme E, Ponec M. Crucial role of fibroblasts in regulating epidermal morphogenesis. Cell Tissue Res 2002; 310:189-99.
20. Pouliot R, Larouche D, Auger FA et al. Reconstructed human skin produced in vitro and grafted on athymic mice. Transplantation 2002; 73:1751-7.
21. Burke JF, Bondoc CC, Quinby WC. Primary burn excision and immediate grafting: a method shortening illness. J Trauma 1974; 14:389-95.
22. Jones JE, Nelson EA. Skin grafting for venous leg ulcers. Cochrone Database Syst Rev 2005; CD001737.
23. Long RE, Falabella AF, Valencia I et al. Treatment of refractory, atypical lower extremity ulcers with tissue-engineered skin (Apligraf). Arch Dermatol 2001; 137:1660-1.
24. Phillips TJ, Manzoor J, Rojas A et al. The longevity of a bilayered skin substitute after application to venous ulcers. Arch Dermatol 2002; 138:1079-81.
25. Omar AA, Mavor AI, Jones AM et al. Treatment of venous leg ulcers with Dermagraft. Eur J Vasc Endovasc Surg 2004; 27:666-72.
26. Marston WA, Hanft J, Norwood P et al. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care 2003; 26:1701-5.
27. Curran MP, Plosker GL. Bilayered bioengineered skin substitute (Apligraf): a review of its use in the treatment of venous leg ulcers and diabetic foot ulcers. BioDrugs 2002; 16:439-55.
28. Brem H, Lyder C. Protocol for the successful treatment of pressure ulcers. Am J Surg 2004; 188:9-17.