Treatment of venous leg ulcers with Dermagraft

European Journal of Vascular and Endovascular Surgery

Volumn 27, Issue 6, 2004, Pages 666-672

  Omar, A A ^a   Mavor, A I D ^b   Jones, A M ^c   Homer Vanniasinkam, S ^b  

^a Faculty of Medicine   (Egypt)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Leg ulceration (treatment); Venous leg ulcer; Wound (chronic)

Indexed keywords

ADULT; AGED; ARTICLE; CAPILLARY DENSITY; CLINICAL ARTICLE; CLINICAL TRIAL; COMPRESSION THERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DEVICE; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; LASER DOPPLER FLOWMETRY; LEG ULCER; MALE; PILOT STUDY; PRIORITY JOURNAL; RANK SUM TEST; SKIN BLOOD FLOW; SKIN GRAFT; SKIN TRANSPLANTATION; TISSUE ENGINEERING; WOUND HEALING;

EID: 2442492958     PISSN: 10785884     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejvs.2004.03.001     Document Type: Article

References (45)

1. Bergan JJ. Overview of potential benefits of direct venous reconstruction. Int Angiol 1985; 4(4):463-466.
2. Hafner J, Bounameaux H, Burg G, Brunner U. Management of venous leg ulcers. VASA 1996; 25(2):161-167.
3. O'Brien JF, Grace PA, Perry IJ et al. Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers. Br J Surg 2003; 90(7):794-798.
4. Moody M. Comparison of Rosidal K and SurePress in the treatment of venous leg ulcers. Br J Nurs 1999; 8(6):345-355.
5. Margolis DJ, Berlin JA, Strom BL. Which venous leg ulcers will heal with limb compression bandages? Am J Med 2000; 109(1):15-19.
6. Colgan MP, Dormandy JA, Jones PW et al. Oxpentifylline treatment of venous ulcers of the leg. BMJ 1990; 300(6730): 972-975.
7. Rudofsky G. Intravenous prostaglandin E1 in the treatment of venous ulcers - a double-blind, placebo-controlled trial. VASA Suppl 1989; 28:39-43.
8. Moneta GL, Porter JM. Non-operative treatment of chronic venous insufficiency In: Rutherford RB, ed. Vascular Surgery. Philadelphia: WB Saunders, 2002: 1999-2007. Chapter 146.
9. Shami SK, Sarin S, Cheatle TR, Scurr JH, Smith PD. Venous ulcers and the superficial venous system. J Vasc Surg 1993; 17(3): 487-490.
10. Zimmet SE. Venous leg ulcers: modern evaluation and management. Dermatol Surg 1999; 25(3):236-241.
11. Douglas WS, Simpson NB. Guidelines for the management of chronic venous leg ulceration. Report of a multidisciplinary workshop. British Association of Dermatologists and the Research Unit of the Royal College of Physicians. Br J Dermatol 1995; 132(3):446-452.
12. Simka M, Majewski E. The social and economic burden of venous leg ulcers: focus on the role of micronized purified flavonoid fraction adjuvant therapy. Am J Clin Dermatol 2003; 4(8):573-581.
13. Olin JW, Beusterien KM, Childs MB et al. Medical costs of treating venous stasis ulcers: evidence from a retrospective cohort study. Vasc Med 1999; 4(1):1-7.
14. Tanaka M, Nakakita N, Kuroyanagi Y. Allogeneic cultured dermal substitute composed of spongy collagen containing fibroblasts: evaluation in animal test. J Biomater Sci Polym Ed 1999; 10(4):433-453.
15. Sacks MS, Chuong CJ, Petroll WM, Kwan M, Halberstadt C. Collagen fiber architecture of a cultured dermal tissue. J Biomech Engng 1997; 119(1):124-127.
16. Naughton G, Mansbridge J, Gentzkow G. A metabolically active human dermal replacement for the treatment of diabetic foot ulcers. Artif Organs 1997; 21(11):1203-1210.
17. Naughton GK, Applegate D. Cryopreserved dermal implants. In: Atala A, Lanza RP, eds. Methods of tissue engineering. New York: Academic Press, 2002: 1157-1176. Chapter 104.
18. Falanga VJ. Tissue engineering in wound repair. Adv Skin Wound Care 2000; 13(2 Suppl):15-19.
19. Kern A, Liu K, Mansbridge J. Modification of fibroblast gamma-interferon responses by extracellular matrix. J Invest Dermatol 2001; 117(1):112-118.
20. Gentzkow GD, Iwasaki SD, Hershon KS et al. Use of dermagraft, a cultured human dermis, to treat diabetic foot ulcers. Diabetes Care 1996; 19(4):350-354.
21. Purdue GF. Dermagraft-TC pivotal efficacy and safety study. J Burn Care Rehabil 1997; 18(1 Pt 2):S13-S14.
22. Purdue GF, Hunt JL, Still Jr JM et al. A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. J Burn Care Rehabil 1997; 18(1 Pt 1): 52-57.
23. Hansbrough JF, Dore C, Hansbrough WB. Clinical trials of a living dermal tissue replacement placed beneath meshed, split-thickness skin grafts on excised burn wounds. J Burn Care Rehabil 1992; 13(5):519-529.
24. Kantor J, Margolis DJ. A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br J Dermatol 2000; 142(5):960-964.
25. Meyer FJ, Burnand KG, Lagattolla NR, Eastham D. Randomized clinical trial comparing the efficacy of two bandaging regimens in the treatment of venous leg ulcers. Br J Surg 2002; 89(1):40-44.
26. Moffatt CJ, Simon DA, Franks PJ et al. Randomised trial comparing two four-layer bandage systems in the management of chronic leg ulceration. Phlebology 1999; 14(4):139-142.
27. Hansbrough JF, Mozingo DW, Kealey GP et al. Clinical trials of a biosynthetic temporary skin replacement, Dermagraft-Transitional Covering, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. J Burn Care Rehabil 1997; 18(1 Pt 1):43-51.
28. Economou TP, Rosenquist MD, Lewis II RW, Kealey GP. An experimental study to determine the effects of Dermagraft on skin graft viability in the presence of bacterial wound contamination. J Burn Care Rehabil 1995; 16(1):27-30.
29. Hanft JR, Surprenant MS. Healing of chronic foot ulcers in diabetic patients treated with a human fibroblast-derived dermis. J Foot Ankle Surg 2002; 41(5):291-299.
30. Marston WA, Hanft J, Norwood P, Pollak R. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care 2003; 26(6):1701-1705.
31. Stacey MC, Burnand KG, Layer GT, Pattison M, Browse NL. Measurement of the healing of venous ulcers. Aust N Z J Surg 1991; 61(11):844-848.
32. Patete PV, Bulgrin JP, Shabani MM, Smith DJ. A non-invasive, three-dimensional, diagnostic laser imaging system for accurate wound analysis. Physiol Meas 1996; 17(2):71-79.
33. Laudanska H, Gustavson B. In-patient treatment of chronic varicose venous ulcers. A randomized trial of cadexomer iodine versus standard dressings. J Int Med Res 1988; 16(6):428-435.
34. Gorin DR, Cordts PR, LaMorte WW, Manzoian JO. The influence of wound geometry on the measurement of wound healing rates in clinical trials. J Vasc Surg 1996; 23(3):524-528.
35. Griffin JW, Tolley EA, Tooms RE, Reyes RA, Clifft JK. A comparison of photographic and transparency-based methods for measuring wound surface area. Phys Ther 1993; 73(2):117-122.
36. Plassmann P. Measuring wounds. J Wound Care 1995; 4(6): 269-272.
37. Gilman TH. Parameter for measurement of wound closure. Wound 1990; 2(3):95-101.
38. Jiang WG, Harding KG. Enhancement of wound tissue expansion and angiogenesis by matrix-embedded fibroblast (dermagraft), a role of hepatocyte growth factor/scatter factor. Int J Mol Med 1998; 2(2):203-210.
39. Cullum N, Nelson EA, Fletcher AW, Sheldon TA. Compression for venous leg ulcers. Cochrane Database Syst Rev 2001; (2):CD000265.
40. Stanley AC, Park HY, Phillips TJ, Russakovsky V, Menzoian JO. Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors. J Vasc Surg 1997; 26(6):994-999. discussion 999-1001.
41. Mansbridge J, Liu K, Patch R, Symons K, Pinney E. Three-dimensional fibroblast culture implant for the treatment of diabetic foot ulcers: metabolic activity and therapeutic range. Tissue Engng 1998; 4(4):403-414.
42. Newton DJ, Khan F, Belch JJ, Mitchell MR, Leese GP. Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy. J Foot Ankle Surg 2002; 41(4):233-237.
43. Mansbridge JN, Liu K, Pinney RE et al. Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers. Diabetes Obes Metab 1999; 1(5):265-279.
44. Pettet G, Chaplain MA, McElwain DL, Byrne HM. On the role of angiogenesis in wound healing. Proc R Soc Lond B Biol Sci 1996; 263(1376):1487-1493.
45. Bennett NT, Schultz GS. Growth factors and wound healing: Part II. Role in normal and chronic wound healing. Am J Surg 1993; 166(1):74-81.