Epidermal growth factor and keratinocyte growth factor differentially regulate epidermal migration, growth, and differentiation

Wound Repair and Regeneration

Volumn 8, Issue 3, 2000, Pages 192-203

  Gibbs, Susan ^a   Pinto, Anna Nubia Silva ^a   Murli, Seema ^a   Huber, Marcel ^b   Hohl, Daniel ^b   Ponec, Maria ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; EPIDERMIS; EPIDERMIS CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; WOUND HEALING;

CELL DIVISION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; EPIDERMIS; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; MEMBRANE PROTEINS; PROTEIN PRECURSORS; TRANSGLUTAMINASES; WOUND HEALING;

EID: 0033946041     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2000.00192.x     Document Type: Article

References (51)

1. Breuing K, Andree C, Helo G, Slama J, Liu PY, Eriksson E. Growth factors in the repair of partial thickness porcine skin wounds. Plastic Reconstr Surg 1997;100:657-64.
2. Greenhalgh DG. The role of growth factors in wound healing. J Trauma 1996;41:159-67.
3. Werner S. Keratinocyte growth factor a unique player in epithelial repair processes. Cytokine Growth Factor Rev 1998;9:153-65.
4. Paladini RD, Takahashi K, Bravo NS, Colombe PA. Onset of reepithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol 1996;132:381-97.
5. Schalkwijk J, Chang A, Janssen P, de Jongh GI, Mier PD. Skin-derived antileukoproteinases (SKALPs): characterization of two new elastase inhibitors from psoriatic epidermis. Br J Dermatol 1990;122:631-41.
6. Wiedow O, Lüdemann J, Utrecht B. Elafin is a potent inhibitor of proteinase-3. Biochem Biophys Res Comm 1991;174:6-10.
7. Alkemade HA, Molhuizen HO, van Viymen-Willems IM, van Haelst UJ, Schalkwijk J. Differential expression of SKALP/elafin in human epidermal tumors. Am J Pathol 1993;143:1679-87.
8. Scalkwijk J, van Vlijmen IM, Alkemade JA, de Jongh G. Immunohistochemical localization of SKALP/elafin in psoriatic epidermis. J Invest Dermatol 1993;100:390-3.
9. van Bergen BH, Andriessen MPM, Spruijt KIJ, van de Kerkhof PCM, Schalkwijk J. Expression of SKALP/elafin during wound healing in human skin. Arch Derm Res 1996;288:458-62.
10. Steinert PM, Marekov LN. The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. J Biol Chem 1995;270:17702-11.
11. Mansbridge JN, Knapp AM. Changes in keratinocyte maturation during wound healing. J Invest Dermatol 1987;89:253-63.
12. Ponec M, de Haas C, Bachra B, Polano M. Effects of glucocorticoids on primary human skin fibroblasts. Arch Dermatol Res 1977; 259:117-23.
13. Ponec M, Kempenaar J, de Floet E. Corticoids and cultured human epidermal keratinocytes: specific intracellular binding and clinical efficacy. J Invest Dermatol 1981;76:211-4.
14. Ponec M, Weerheim A, Kempenaar J, Mommaas A, Nugteren D. Lipid composition of cultured keratinocytes in relation to their differentiation. J Lipid Res 1988;29:949-61.
15. Boyce ST, Williams ML. Lipid supplemented medium induces lamellar bodies and precursors of barrier lipids in cultured analogues of human skin. J Invest Dermatol 1993;101:180-4
16. Ponec M, Weerheim A, Kempenaar J, Mulder A, Gooris G, Bouwstra J, Mommaas A. The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol 1997;109:348-55.
17. Hudson D, Weiland K, Dooley T, Simon M, Watt F. Characterization of eight monoclonal antibodies to involucrin. Hybridoma 1992;11: 367-79.
18. Purkis PE, Steel JB, Mackenzie IC. Antibody markers of basal cells in complex epithelia. J Cell Sci 1990;97:39-50.
19. Thatcher SM, Rice RH. Keratinocyte specific transglutaminase of cultured human epidermal cells: relation to cross linked envelope formation and terminal differentiation. Cell 1985;40:685-95.
20. Hohl D, Aeschlimann D, Huber M. In vitro and rapid in situ transglutaminase assays for congenital ichthyoses - a comparative study. J Invest Dermatol 1998;110:268-71.
21. Ponec M, Weerheim A. Retinoids and lipid changes in keratinocytes. In: Packer L, editor. Methods in enzymology. Retinoids, vol 190, Part B. San Diego: Academic Press, 1990: 30-41.
22. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physio 1959;37:911-7.
23. Gibbs S, Boelsma E, Kempenaar J, Ponec M. Temperature sensitive regulation of epidermal morphogenesis and the expression of cornified envelope precursors by EGF and TGFa. Cell Tiss Res 1998;292:107-14.
24. Jiang CK, Magnaldo T, Ohtsuki M, Freedberg IM, Bernerd F, Blumenberg M. Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation- associated keratins 6 and 16. Proc Natl Acad Sci USA 1993; 90:6786-90.
25. Latkowski JM, Freedberg IM, Blumenberg M. Keratinocyte growth factor and keratin gene regulation. J Dermatol Science 1995;9: 36-44.
26. Takahashi K, Paladini RD, Coulombe PA. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J Biol Chem 1995;270:18581-92.
27. Smith FJD, Jonkman MF, van Goor H, Coleman CM, Covello SP, Uitto J, McLean WHI. A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2. Hum Mol Genet 1998;7:1143-8.
28. Yoshikawa K, Katagata Y, Kondo S. Relative amounts of keratin 17 are higher than those of keratin 16 in hair-follicle-derived tumors in comparison with nonfollicular epithelial skin tumors. J Invest Dermatol 1995;104:396-400.
29. Yoshikawa K, Katagata Y, Kondo S. Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma. J Dermatol Science 1998;17:15-23.
30. Machesney M, Tidman N, Waseem A, Kirby L, Leigh I. Activated keratinocytes in the epidermis of hypertrophic scars. Am J Pathol 1998;152:1133-41.
31. Willis CM, Reiche L, Wilkinson JD. Keratin 17 is expressed during the course of SLS-induced irritant contact dermatitis, but unlike keratin 16, the degree of expression is unrelated to the density of dividing keratinocytes. Contact Dermatitis 1998;39:21-7.
32. Liu K, Kasper M, Trott KR. Changes in keratinocyte differentiation during accelerated repopulation of the irradiated mouse epidermis. Int J Radiat Biol 1996;69:763-9.
33. Bauman H, Gauldie J. The acute phase response. Immunol Today 1994;15:74-80.
34. Chih-Shan JC, Lavker RM, Rodeck U, Risse B, Jensen PJ. Use of a serum-free epidermal culture model to show deleterious effects of epidermal growth factor on morphogenesis and differentiation. J Invest Dermatol 1995;104:107-12.
35. Marchese C, Rubin J, Ron D, Faggioni A, Torrisi MR, Messina A, Frati L, Aaronson SA. Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J Cell Physiol 1990;144:326-32.
36. Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cunha GR, Finch PW. Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction. In: Goldberg ID, Rosen EM, editors. Epithelial-mesenchymal interactions in cancer. Basel, Switzerland: Birkhäuser Verlag, 1995: 191-214.
37. Staiano-Coico L, Krueger JG, Rubin JS, D'limi S, Vallat NP, Valentino L, Fahey T, Hawes A, Kingston G, Madden MR, Mathwich M, Gottlieb AB, Aaronson SA. Human keratinocyte growth factor effects in a porcine model of epidermal wound healing. J Exp Med 1993;178:865-78.
38. Zeigler ME, Krause S, Karmiol S, Varani J. Growth factor-induced epidermal invasion of the dermis in human skin organ culture: dermal invasion correlated with epithelial cell motility. Invasion Metastasis 1996;16:3-10.
39. Peehl DM, Wong ST, Rubin JS. KGF and EGF differentially regulate the phenotype of prostatic epithelial cells. Growth Reg 1996;6: 22-31.
40. Ando Y, Jensen PJ. Epidermal growth factor and insulin-like growth factor I enhance keratinocyte migration. J Invest Dermatol 1993;100:633-9.
41. Tsuboi R, Sato C, Kurita Y, Ron D, Rubin JS, Ogawa H. Keratinocyte growth factor (FGF-7) stimulates migration and plasminogen activator activity of normal human keratinocytes. J Invest Dermatol 1993;101:49-53.
42. Pierce GF, Yanagihara D, Hopchin K, Danilenko DM, Hsu E, Kenney WC, Morris CF. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor. J Exp Med 1994; 179:831-10.
43. Werner S, Peters KG, Longaker MT, Fuller-Pace F, Banda MJ, Williams LT. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci USA 1992;89:6896-900.
44. Marchese C, Chedid M, Dirsch OR, Csaky KG, Santanelli F, Latini C, LaRochelle WJ, Torrisi MR, Aaronson SA. Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. J Exp Med 1995;182:1369-76.
45. Guo L, Degenstein L, Fuchs E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev 1996;10:165-75.
46. Jimenez PA, Rampy MA. Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. J Surg Res 1999;81:238-42.
47. Xia YP, Zhao Y, Marcus J, Jimenez PA, Ruben SM, Moore PA, Khan F, Mustoe TA. Effects of keratinocyte growth factor-2 (KGF-2) on wound healing in an ischaemia-impaired rabbit ear model and on scar formation. J Pathol 1999;188:431-8.
48. Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 1994;266:819-22.
49. Murillas R, Larcher F, Conti CJ, Santos M, Ullrich A, Jorcano JL. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J 1995;14:5216-23.
50. King L, Gates R, Stoscheck C, Nanney L. The EGF/TGFα receptor in skin. J Invest Dermatol 1990;94:164S-170S.
51. Ebner R, Derynck R. Epidermal growth factor and transforming growth factor α: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul 1991;2:599-612.