Expression of a cyclin E1 isoform in mice is correlated with the quiescent cell cycle status of hepatocytes in vivo

Hepatology

Volumn 44, Issue 1, 2006, Pages 164-173

  Zschemisch, Nils Holger ^a   Liedtke, Christian ^b   Dierssen, Uta ^b   Nevzorova, Yulia A ^b   Wüstefeld, Torsten ^c   Borlak, Jürgen ^d   Manns, Michael P ^a   Trautwein, Christian ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c FOX CHASE CANCER CENTER   (United States)

^d FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYCLIN E1 ANTIGEN; CYCLIN E1 DELTA3 ANTIGEN; CYCLIN E1 DELTA4 ANTIGEN; CYCLIN E1 DELTA5 ANTIGEN; CYCLIN E1 DELTA8 ANTIGEN; CYCLIN E1 IN3 ANTIGEN; MESSENGER RNA; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PHASE; CELL CYCLE REGULATION; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; IN VIVO STUDY; LIVER CELL; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELLS, CULTURED; CYCLIN E; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM;

EID: 33745892101     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21224     Document Type: Article

References (45)

1. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, et al. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 1992;257:1689-1694.
2. Dulic V, Lew DJ, Reed SI. Association of human cyclin E with periodic G1-S phase protein kinase. Science 1992;257:1958-1961.
3. Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (CLN) function in yeast. Cell 1991;66:1197-1206.
4. Möröy T, Geisen C. Cyclin E. Int J Biochem Cell Biol 2004;36:1424-1439.
5. Lüdde T, Streetz KL, Plümpe J, Liedtke C, Manns MP, Trautwein C. Ras adenoviruses modulate cyclin E protein expression and DNA syntesis after partial hepatectomy. Oncogene 2001;20:5264-5278.
6. Wüstefeld T, Rakemann T, Kubicka S, Manns MP, Trautwein C. Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice. HEPATOLOGY 2000;32:514-522.
7. Keyomarsi K, Pardee A. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci U S A 1993;90:1112-1116.
8. Richter J, Wagner U, Kononen J, Fijan A, Bruderer J, Schmid U, et al. High-throughput tissue microarray analysis of cyclin E gene amplification and overexpression in urinary bladder cancer. Am J Pathol 2000;157:787-794.
9. Jung Y-J, Lee K-H, Choi D-W, Han CJ, Jeong, SH, Kim KC, et al. Reciprocal expressions of cyclin E and cyclin D1 in hepatocellular carcinoma. Cancer Lett 2001;168:57-63.
10. Ohashi R, Gao C, Miyazaki M, Hamazaki K, Tsuji T, Inoue Y, et al. Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas. Anticancer Res 2001;21:657-662.
11. Schraml P, Bucher C, Bissig H, Nocito A, Haas P, Wilber K, et al. Cyclin E overexpression and amplification in human tumours. J Pathol 2003;200:375-382.
12. Ohtsubo M, Roberts JM. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 1993;259:1908-1912.
13. Resnitzky D, Gossen M, Bujard H, Reed SI. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol 1994;14:1669-1679.
14. Wimmel A, Lucibello FC, Sewing A, Adolph S, Müller R. Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E. Oncogene 1994;9:995-997.
15. Spruck CH, Won K-A, Reed SI. Deregulated cyclin E induces chromosome instability. Nature 1999;401:297-300.
16. Roberts GC, Smith CWJ. Alternative splicing: combinatorial output from the genome. Curr Opin Chem Biol 2002;6:375-383.
17. Nissim-Rafinia M, Kerem B. Splicing regulation as a potential genetic modifier. Trends Genet 2002;18:123-127.
18. Caceres JF, Kornblihtt AR. Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet 2002;18:186-193.
19. Sewing A, Rönicke V, Bürger C, Funk M, Müller R. Alternative splicing of human cyclin E. J Cell Sci 1994;107:581-588.
20. T, a new splice variant of human cyclin E with the unique pattern during cell cycle progression and differentiation. Nucleic Acids Res 1997;25:2098-2105.
21. Porter CP, Keyomarsi K. Novel splice variants of cyclin E with altered substrate specificity. Nucleic Acids Res 2000;28:e101.
22. Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes & Dev 2004;18:2699-2711.
23. Yu Q, Sicinski P. Mammalian cell cycle without cyclin E-cdk2. Cell Cycle 2004;3:292-295.
24. Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, et al. Cyclin E ablation in the mouse. Cell 2003;114:431-443.
25. Parisi T, Beck AR, Rougier N, McNeil T, Lucian L, Werb Z, et al. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J 2003;22:4794-4803.
26. Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R, et al. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Gent 2003;35:25-31.
27. Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. Cdk2 knockout mice are viable. Curr Biol 2003;13:1775-1785.
28. 1 antitrypsin/ ONC mouse). Biologicals 1990;18:191-198.
29. Perraud F, Dalemans W, Gendrault J-L, Dreyer D, Ali-Hadji D, Faure T, et al. Characterization of trans-immortalized hepatic cell lines established from transgenic mice. Exp Cell Res 1991;195:59-65.
30. Tönjes RR, Löhler J, O'Sullivan JF, Kay GF, Schmidt GH, Dalemans W, et al. Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice. Oncogene 1995;10:765-768.
31. Liedtke C, Plümpe J, Kubicka S, Bradham CA, Manns MP, Brenner DA, et al. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. HEPATOLOGY 2002;36:315-325.
32. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
33. Maniatis T, Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 2002;418:236-243.
34. KIP1 is an independent predictor of recurrence after surgical resection in patients with small hepatocellular carcinoma. J Hepatol 2003;38:591-597.
35. Kim H, Lee MJ, Kim MR, Chung IP, Kim YM, Lee JY, et al. Expression of cyclin D1, cyclin E, cdk4 and loss of heterozygosity of 8p, 13q, 17p in hepatocellular carcinoma: comparison study of childhood and adult hepatocellular carcinoma. Liver 2000;20:173-178.
36. Zhou Q, He Q, Liang L-J. Expression of p27, cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance. World J Gastroenterol 2003;9:2450-2454.
37. Matsumoto Y, Maller JL. A centrosomal localization signal in cyclin E required for cdk2-independent S phase entry. Science 2004;306:885-888.
38. Horton LE, Templeton DJ. The cyclin box and c-terminus of cyclins A and E specify cdk activation and substrate specificity. Oncogene 1997;14:491-498.
39. Geisen C, Möröy T. The oncogenic activity of cyclin E is not confined to cdk2 activation alone but relies on several other, distinct functions of the protein. J Biol Chem 2002;277:39909-39918.
40. Kim T-Y, Kaelin WG. Differential control of transcription by DNA-bound cyclins. Mol Biol Cell 2001;12:2207-2217.
41. Contreras A, Hale T, Stenoien DL, Rosen JM, Mancini MA, Herrera RE. The dynamic mobility of histone H1 is regulated by cyclin/cdk phosphorylation. Mol Cell Biol 2003;23:8626-8636.
42. Li H, Lahti JM, Kidd VJ. Alternative spliced cyclin C mRNA is widely expressed, cell cycle regulated, and encodes a truncated cyclin box. Oncogene 1996;13:705-712.
43. Ren S, Rollins BJ. Cyclin C/Cdk3 promotes Rb-dependent GO exit. Cell 2004;117:239-251.
44. Sage J. Cyclin C makes an entry into the cell cycle. Dev Cell 2004;6:607-616.
45. Moore JD, Kornbluth S, Hunt T. Identification of the nuclear localization signal in xenopus cyclin E and analysis of its role in replication and mitosis. Mol Biol Cell 2002;13:4388-4400.