Stressed cells cope with protein overload

Science

Volumn 313, Issue 5783, 2006, Pages 52-53

  Ron, David ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DEGRADATION; PROTEINS; RNA;

ENDOPLASMIC RETICULUM; ER PROTEINS; EUKARYOTIC CELLS; UNFOLDED PROTEINS;

CELLS;

MESSENGER RNA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; INOSITOL REQUIRING ENZYME 1, DROSOPHILA; INOSITOL REQUIRING ENZYME-1, DROSOPHILA; MEMBRANE PROTEIN; RIBONUCLEASE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; X BOX BINDING PROTEIN (RF X); X BOX BINDING PROTEIN (RF-X);

DEGRADATION; EUKARYOTE; PROTEIN; RNA;

CYTOLOGY; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN FOLDING; REVIEW; RNA DEGRADATION; RNA TRANSLATION; STRESS; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; CYTOSOL; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; NOTE; PHYSIOLOGY; PROTEIN SYNTHESIS; PROTEIN TERTIARY STRUCTURE; RNA STABILITY; SIGNAL TRANSDUCTION;

EUKARYOTA;

ANIMALS; CELL LINE; CYTOSOL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 33745891787     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1130469     Document Type: Review

References (11)

1. R. J. Kaufman, J. Clin. Invest. 110, 1389 (2002).
2. J. Hollien, J. S. Weissman, Science 313, 104 (2006).
3. C. Patil, P. Walter, Curr. Opin. Cell Biol. 13, 349 (2001).
4. H. P. Harding, M. Calfon, F. Urano, I. Novoa, D. Ron, Ann. Rev. Cell Dev. Biol. 18, 575 (2002).
5. C. Sidrauski, P. Walter, Cell 90, 1031 (1997).
6. H. Yoshida, T. Matsui, A. Yamamoto, T. Okada, K. Mori, Cell 107, 881 (2001).
7. M. Calfon et al., Nature 415, 92 (2002).
8. J. J. Credle, J. S. Finer-Moore, F. R. Papa, R. M. Stroud, P. Walter, Proc. Natl. Acad. Sci. U.S.A 102, 18773 (2005).
9. F. Urano et al., Science 287, 664 (2000).
10. C. Hetz et al. Science 312, 572 (2006).
11. K. J. Travers et al., Cell 101, 249 (2000).