Effect of visible light on normal and P23H-3 transgenic rat retinas: Characterization of a novel retinoic acid derivative present in the P23H-3 retina

Photochemistry and Photobiology

Volumn 82, Issue 3, 2006, Pages 741-745

  Duncan, Todd ^a   Wiggert, Barbara ^a   Whittaker, Noel ^b   Darrow, Ruth ^c   Organisciak, Daniel T ^c  

^a NATIONAL EYE INSTITUTE   (United States)

^b Bldg 142   (United States)

^c WRIGHT STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; RHODOPSIN;

ANIMAL; ARTICLE; GENETICS; ISOLATION AND PURIFICATION; LIGHT; MUTATION; RADIATION EXPOSURE; RAT; RETINA; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; LIGHT; MUTATION; RATS; RETINA; RHODOPSIN; TRETINOIN;

ANIMALIA;

EID: 33745852621     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/2005-10-05-RA-712     Document Type: Article

References (32)

1. Noell, W. K., V. S. Walker, B. S. Kang and S. Berman (1966) Retinal damage by light in rats. Invest. Ophthalmol. Vis. Sci. 5, 450-473.
2. Organisciak, D. T. and B. S. Winkler (1994) Retinal light damage: practical and theoretical considerations. In Progress in Retinal and Eye Research (Edited by N. Osborne and G. Chader), pp. 1-24. Pergamon Press, New York.
3. Rapp, L. M. (1995) Retinal phototoxicity. In Handbook of Neurotoxicology (Edited by L. W. Chang and R. S. Dyer), pp. 963-1003. Marcel Dekker, New York.
4. Remé, C. E., F. Hafezi, A. Marti, K. Munz and J. J. Reinboth (1998) Light damage to retina and pigment epithelium. In The Retinal Pigment Epithelium: Function and Disease (Edited by M. F. Marmor and T. J. Wolfensberger), pp. 563-586. Oxford University Press, New York.
5. Wenzel, A., C. Grimm, M. Samardzija and C. E. Remé (2005) Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. In Progress in Retinal and Eye Research (Edited by N. Osborne and G. Chader), pp. 275-306. Pergamon Press, New York.
6. Organisciak, D. T., R. M. Darrow, L. Barsalou, R. K. Kutty, G. Kutty and B. Wiggert (1998) Light history and age-related changes in retinal light damage. Invest. Ophthalmol. Vis. Sci. 39, 1107-1116.
7. LaVail, M. M., G. M. Gorrin, M. A. Repaci, L. A. Thomas and H. M. Ginsberg (1987) Genetic regulation of light damage to photoreceptors. Invest. Ophthalmol. Vis. Sci. 28, 1043-1048.
8. LaVail, M. M., G. M. Gorrin and M. A. Repaci (1987) Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice. Curr. Eye Res. 6, 825-834.
9. Wiechmann, A. F. and W. K. O'Steen (1992) Melatonin increases photoreceptor susceptibility to light-induced damage. Invest. Ophthalmol. Vis. Sci. 33, 1894-1902.
10. Organisciak, D. T., R. M. Darrow, L. Barsalou, R. K. Kutty and B. Wiggert (2000) Circadian-dependent retinal light damage in rats. Invest. Ophthalmol. Vis. Sci. 41, 3694-3701.
11. Williams, T. P. and W. L. Howell (1983) Action spectrum of retinal light-damage in albino rats. Invest. Ophthalmol. Vis. Sci. 24, 285-287.
12. Grimm, C. A., Wenzel, F. Hafezi, S. Yu, T. M. Redmond and C. E. Remé. Protection of RPE65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration. Nat. Genet. 25, 63-66.
13. Naash, M. L., N. S. Peachy, Z.-Y. Li, C. C. Gryczan, Y. Goto, J. Blanks, A. H. Milam and H. Ripps (1996) Light-induced acceleration of photoreceptor cell degeneration in transgenic mice expressing mutant rhodopsin. Invest. Ophthalmol. Vis. Sci. 37, 775-782.
14. Wang, M., T. T. Lam, M. O. M. Tso and M. L. Naash (1997) Expression of a mutant opsin gene increases the susceptibility of the retina to light damage. Vis. Neurosci. 14, 55-62.
15. Cideciyan, A. V., S. G. Jacobson, T. S. Aleman, D. Gu, S. E. Pearce-Kelling, A. Sumaroka, G. M. Acland and G. D. Aguirre (2005) In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. Proc. Natl. Acad. Sci. U S A 102, 5233-5238.
16. Olsson, J. E., J. W. Gordon, B. S. Pawlyk, D. Roof, A. Hayes, R. S. Molday, S. Mukai, G. S. Cowley, E. L. Berson and T. P. Dryja (1992) Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9, 815-830.
17. Organisciak, D. T. and T. Sarna (2001) Genetics, age and light-induced degenerations of the retina and retinal pigment epithelium. In Photobiology for the 21st Century (Edited by T. P. Coohil and D. P. Valenzena), pp. 81-100. Valdenmar Publishing, Overland Park, KS.
18. Organisciak, D. T., R. M. Darrow, L. Barsalou, R. K. Kutty, and B. Wiggert (2003) Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations. Invest. Ophthalmol. Vis. Sci. 44, 486-492.
19. Walsh, N., D. van Driel, L. Lee and J. Stone (2004) Multiple vulnerability of photoreceptors to mesopic light in the P23H transgenic rat. Brain Res. 1013, 194-203.
20. Dryja, T. P., L. B. Hahn, G. S. Cowley, T. L. McGee and E. L. Berson (1991) Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa. Proc. Natl. Acad. Sci. U S A 88, 9370-9374.
21. Wald, G. and R. Hubbard (1994) The reduction of retinene to vitamin A in vitro. J. Gen. Physiol. 32, 367-389.
22. Palczewski, K., S. Jager, J. Buczylko, R. K. Crouch, D. L. Bredberg, K. P. Hofmann, M. A. Asson-Batres and J. C. Saari (1994) Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry 33, 13,741-13,750.
23. Rattner, A., P. M. Smallwood and J. Nathans (2000) Identification and characterization of all-trans retinol dehydrogenase from photoreceptor segments, the visual cycle enzyme that reduces all-trans retinal to all-trans retinol. J. Biol. Chem. 275, 11,034-11,043.
24. McCaffery, P., J. Mey and U. C. Drager (1996) Light-mediated retinoic acid production. Proc. Natl. Acad. Sci. U S A 93, 12,570-12,574.
25. Wei, L.-N. (2003) Retinoid receptors and their coregulators. Annu. Rev. Pharmacol. Toxicol. 43, 47-72.
26. Streichert, L. C., C. D. Birnbach and T. A. Reh (1999) A diffusible factor from normal retinal cells promotes rod photoreceptor survival in an in vitro model of retinitis pigmentosa. J. Neurobiol. 39, 475-490.
27. Noell, W. K. and R. Albrecht (1971) Irreversible effects of visible light on the retina: role of vitamin A. Science 172, 76-80.
28. Bicknell, I. R., R. Darrow, L. Barsalou, S. J. Fliesler and D. T. Organisciak (2002) Alterations in retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats. Mol. Vis. 8, 333-340.
29. Anderson, R. E., M. B. Maude, M. McClellan, M. T. Matthes, D. Yasumura and M. M. LaVail (2002) Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S344ter rhodopsin mutations. Mol. Vis. 8, 351-358.
30. Vaughan, D. K., S. F. Coulibaly, R. M. Darrow and D. T. Organisciak (2003) A morphometric study of light-induced damage in transgenic rat models of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 44, 848-855.
31. Frolik, C. A. and J. A. Olson (1984) Extraction, separation, and chemical analysis of retinoids. In The Retinoids, Vol. 1 (Edited by M. B. Sporn, A. B. Roberts and D. S. Goodman), pp. 182-233. Academic Press, New York.
32. Barua, A. B. and H. C. Furr (1998) Properties of retinoids: structure, handling, and preparation. In Retinoid Protocols, Vol. 89 (Edited by C. P. F. Redfern), pp. 3-28. Humana Press, Totowa.